The Role of Coenzyme Q10 in Statin-Associated Myopathy
Open accessAbstract
Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) are currently the most effective medications for reducing low-density lipoprotein cholesterol concentrations. Although generally safe, they have been associated with a variety of myopathic complaints. Statins block production of farnesyl pyrophosphate, an intermediate in the synthesis of ubiquinone or coenzyme Q10 (CoQ10). This fact, plus the role of CoQ10 in mitochondrial energy production, has prompted the hypothesis that statin-induced CoQ10 deficiency is involved in the pathogenesis of statin myopathy. We identified English language articles relating statin treatment and CoQ10 levels via a PubMed search through August 2006. Abstracts were reviewed and articles addressing the relationship between statin treatment and CoQ10 levels were examined in detail. Statin treatment reduces circulating levels of CoQ10. The effect of statin therapy on intramuscular levels of CoQ10 is not clear, and data on intramuscular CoQ10 levels in symptomatic patients with statin-associated myopathy are scarce. Mitochondrial function may be impaired by statin therapy, and this effect may be exacerbated by exercise. Supplementation can raise the circulating levels of CoQ10, but data on the effect of CoQ10 supplementation on myopathic symptoms are scarce and contradictory. We conclude that there is insufficient evidence to prove the etiologic role of CoQ10 deficiency in statin-associated myopathy and that large, well-designed clinical trials are required to address this issue. The routine use of CoQ10 cannot be recommended in statin-treated patients. Nevertheless, there are no known risks to this supplement and there is some anecdotal and preliminary trial evidence of its effectiveness. Consequently, CoQ10 can be tested in patients requiring statin treatment, who develop statin myalgia, and who cannot be satisfactorily treated with other agents. Some patients may respond, if only via a placebo effect.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
One possible mechanism of statin-induced myopathy is mitochondrial dysfunction resulting from a reduction in circulating or intramuscular CoQ10.
“one possible mechanism is mitochondrial dysfunction resulting from a reduction in circulating/intramuscular CoQ10.3, 4”
From Effects of Coenzyme Q10 on Statin‐Induced Myopathy: An Updated Meta‐Analysis of Randomized Controlled Trials (2018) · cites this paper as [4]
Previous studies demonstrated a reduction in coenzyme Q10 after statin treatment, which might be associated with statin-induced myopathy.
“Previous studies4, 5, 6 have demonstrated a reduction in coenzyme Q10 (CoQ10) after statin treatment, which might be associated with statin‐induced myopathy.”
From Effects of Coenzyme Q10 on Statin‐Induced Myopathy: An Updated Meta‐Analysis of Randomized Controlled Trials (2018) · cites this paper as [4]
Several small studies using respiratory exchange ratios during exercise suggested the possibility of statin-induced abnormalities in mitochondrial function during exercise.
“Using respiratory exchange ratios during exercise as an indirect measure of mitochondrial function, several small studies have suggested the possibility of statin-induced abnormalities in mitochondrial function during exercise.88”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Thompson, P. D., Clarkson, P., & Karas, R. H. (2003) · JAMA · doi:10.1001/jama.289.13.1681 · Cited by 1,463 · see citing works
Self-citationCerivastatin and Reports of Fatal Rhabdomyolysis
Staffa, J. A., Chang, J. T., & Green, L. (2002) · New England Journal of Medicine · doi:10.1056/nejm200202143460721 · Cited by 627 · see citing works
Isolation of a quinone from beef heart mitochondria
Crane, F. L., Hatefi, Y., Lester, R. L., & Widmer, C. (1957) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(57)90457-2 · Cited by 588 · see citing works
Statin-associated myopathy with normal creatine kinase levels
Phillips, P. S., Haas, R. H., Bannykh, S., Hathaway, S., Gray, N. L., Kimura, B. J., Vladutiu, G. D., England, J. D. F., & and the Scripps Mercy Clinical Research Center* (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-137-7-200210010-00009 · Cited by 565 · see citing works
Lovastatin decreases coenzyme Q levels in humans.
Folkers, K., Langsjoen, P. H., Willis, R. A., Richardson, P. C., Xia, L., Ye, C. Q., & Tamagawa, H. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.22.8931 · Cited by 426 · see citing works
Phase I study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer.
Thibault, A., Samid, D., Tompkins, A. C., Figg, W. D., Cooper, M. R., Hohl, R. J., Trepel, J. B., Liang, B., Patronas, N., Venzon, D. J., et al. (1996) · PubMed · Cited by 362 · see citing works
Ghirlanda, G., Oradei, A., Manto, A., Lippa, S., Uccioli, L., Caputo, S., Greco, A. V., & Littarru, G. P. (1993) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1993.tb03948.x · Cited by 324 · see citing works
High-dose statins and skeletal muscle metabolism in humans: a randomized, controlled trial
PAIVA, H., THELEN, K., COSTER, R., SMET, J., PAEPE, B., MATTILA, K., LAAKSO, J., LEHTIMAKI, T., VONBERGMANN, K., & LUTJOHANN, D. (2005) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2005.03.006 · Cited by 308 · see citing works
Antioxidant and prooxidant properties of mitochondrial Coenzyme Q
James, A. M., Smith, R. A. J., & Murphy, M. P. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2003.12.025 · Cited by 292 · see citing works
DE PINIEUX, G., CHARIOT, P., AMMI‐SAÏD, M., LOUARN, F., LEJONC, J. L., ASTIER, A., JACOTOT, B., & GHERARDI, R. (1996) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.1996.04178.x · Cited by 262 · see citing works
Davidson, M. H., McKenney, J. M., Stein, E. A., Schrott, H. G., Bakker-Arkema, R. G., Fayyad, R. S., & Black, D. M. (1997) · The American Journal of Cardiology · doi:10.1016/s0002-9149(97)00174-4 · Cited by 233 · see citing works
Rundek, T., Naini, A., Sacco, R. L., Coates, K., & DiMauro, S. (2004) · Archives of Neurology · doi:10.1001/archneur.61.6.889 · Cited by 229 · see citing works
Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors
Mortensen, S. A., Leth, A., Agner, E., & Rohde, M. (1997) · Molecular Aspects of Medicine · doi:10.1016/s0098-2997(97)00014-9 · Cited by 199 · see citing works
Jula, A., Marniemi, J., Huupponen, R., Virtanen, A., Rastas, M., & Rönnemaa, T. (2002) · JAMA · doi:10.1001/jama.287.5.598 · Cited by 198 · see citing works
Muscle coenzyme Q10 level in statin-related myopathy
Lamperti, C., Naini, A. B., Lucchini, V., Prelle, A., Bresolin, N., Moggio, M., Sciacco, M., Kaufmann, P., & DiMauro, S. (2005) · Archives of Neurology · doi:10.1001/archneur.62.11.1709 · Cited by 178 · see citing works
Laaksonen, R., Jokelainen, K., Sahi, T., Tikkanen, M. J., & Himberg, J.-J. (1995) · Clinical Pharmacology & Therapeutics · doi:10.1016/0009-9236(95)90266-x · Cited by 177 · see citing works
Laaksonen, R., Jokelainen, K., Laakso, J., Sahi, T., Härkönen, M., Tikkanen, M. J., & Himberg, J.-J. (1996) · The American Journal of Cardiology · doi:10.1016/s0002-9149(97)89180-1 · Cited by 171 · see citing works
Paolisso, G., Barbagallo, M., Petrella, G., Ragno, E., Barbieri, M., Giordano, M., & Varricchio, M. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00352-4 · Cited by 171 · see citing works
Morand, O. H., Aebi, J. D., Dehmlow, H., Ji, Y., Gains, N., Lengsfeld, H., & Himber, J. (1997) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37449-6 · Cited by 158 · see citing works
Phase II Study of High-Dose Lovastatin in Patients with Advanced Gastric Adenocarcinoma
Kim, W. S., Kim, M. M., Choi, H. J., Yoon, S., Lee, M. H., Park, K., Park, C. H., & Kang, W. K. (2001) · Investigational New Drugs · doi:10.1023/a:1006481423298 · Cited by 137 · see citing works
Lovastatin decreases coenzyme Q levels in rats.
Willis, R. A., Folkers, K., Tucker, J. L., Ye, C. Q., Xia, L., & Tamagawa, H. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.22.8928 · Cited by 135 · see citing works
Schaefer, W. H., Lawrence, J. W., Loughlin, A. F., Stoffregen, D. A., Mixson, L. A., Dean, D. C., Raab, C. E., Yu, N. X., Lankas, G. R., & Frederick, C. B. (2003) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2003.08.013 · Cited by 131 · see citing works
Nakahara, K., Kuriyama, M., Sonoda, Y., Yoshidome, H., Nakagawa, H., Fujiyama, J., Higuchi, I., & Osame, M. (1998) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1998.8491 · Cited by 119 · see citing works
Tomasetti, M., Alleva, R., Solenghi, M. D., & Littarru, G. P. (1999) · BioFactors · doi:10.1002/biof.5520090218 · Cited by 109 · see citing works
Plasma coenzyme Q (ubiquinone) concentrations in patients treated with simvastatin.
Watts, G. F., Castelluccio, C., Rice-Evans, C. A., Taub, N. A., Baum, H., & Quinn, P. J. (1993) · Journal of Clinical Pathology · doi:10.1136/jcp.46.11.1055 · Cited by 109 · see citing works
Silver, M. A., Langsjoen, P. H., Szabo, S., Patil, H., & Zelinger, A. B. (2004) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2004.07.121 · Cited by 102 · see citing works
Simvastatin-induced rhabdomyolysis followed by a melas syndrome
Chariot, P., Abadia, R., Agnus, D., Danan, C., Charpentier, C., & Gherasdi, R. K. (1993) · The American Journal of Medicine · doi:10.1016/0002-9343(93)90129-d · Cited by 95 · see citing works
Laaksonen, R., Ojala, J.-P., Tikkanen, M. J., & Himberg, J. (1994) · European Journal of Clinical Pharmacology · doi:10.1007/bf00194398 · Cited by 94 · see citing works
Effect of Ezetimibe and/or Simvastatin on Coenzyme Q10 Levels in Plasma
Berthold, H. K., Naini, A., Mauro, S. D., Hallikainen, M., Gylling, H. K., Krone, W., & Gouni‐Berthold, I. (2006) · Drug Safety · doi:10.2165/00002018-200629080-00007 · Cited by 86 · see citing works
The effect of pravastatin and atorvastatin on coenzyme Q10
Bleske, B. E., Willis, R. A., Anthony, M. J., Casselberry, N., Datwani, M., Uhley, V. E., Secontine, S. G., & Shea, M. J. (2001) · American Heart Journal · doi:10.1067/mhj.2001.116762 · Cited by 77 · see citing works
Interactions between ubiquinones and vitamins in membranes and cells
Constantinescu, A., Maguire, J. J., & Packer, L. (1994) · Molecular Aspects of Medicine · doi:10.1016/0098-2997(94)90013-2 · Cited by 73 · see citing works
Elmberger, P. G., Kalén, A., Lund, E. G., Reihnér, E., Eriksson, M., Berglund, L., Angelin, B., & Dallner, G. (1991) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41990-x · Cited by 72 · see citing works
Bargossi, A., Grossi, G., Fiorella, P. L., Gaddi, A. V., Giulio, R. D., & Battino, M. A. (1994) · Molecular Aspects of Medicine · doi:10.1016/0098-2997(94)90028-0 · Cited by 69 · see citing works
Human, J. A., Ubbink, J., Jerling, J. C., Delport, R., Vermaak, W. J. H., Vorster, H. H., Lagendijk, J., & Potgieter, H. C. (1997) · Clinica Chimica Acta · doi:10.1016/s0009-8981(97)06557-1 · Cited by 59 · see citing works
Statin myotoxicity is associated with changes in the cardiopulmonary function
Phillips, P. S., Phillips, C. T., Sullivan, M. J., Naviaux, R. K., & Haas, R. (2004) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2004.06.014 · Cited by 59 · see citing works
Effects of HMG-CoA reductase inhibitors on skeletal muscles of rabbits
Fukami, M., Maeda, N., Fukushige, J., Kogure, Y., Shimada, Y., Ogawa, T., & Tsujita, Y. (1993) · Research in Experimental Medicine · doi:10.1007/bf02576234 · Cited by 58 · see citing works
Satoh, K., Yamato, A., Nakai, T., et al. (1995) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1995.tb16679.x · Cited by 56 · see citing works
Statins Provoking MELAS Syndrome
Thomas, J. E., Lee, N., & Thompson, P. D. (2007) · European Neurology · doi:10.1159/000101287 · Cited by 52 · see citing works
Self-citationde Lorgeril, M., Salen, P., Bontemps, L., Bélichard, P., GEYSSANT, A., & Itti, R. (1999) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199903000-00018 · Cited by 51 · see citing works
Interactions Between Ascorbyl Free Radical and Coenzyme Q at the Plasma Membrane
Arroyo, A., Navarro, F., Gómez-Dı́az, C., Crane, F. L., Alcain, F. J., Navas, P., & Villalba, J. M. (2000) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1005568132027 · Cited by 47 · see citing works
Miyake, Y., Shouzu, A., Nishikawa, M., Yonemoto, T., Shimizu, H., Omoto, S., Hayakawa, T., & Inada, M. (2011) · Arzneimittelforschung · doi:10.1055/s-0031-1300422 · Cited by 47 · see citing works
Statin-associated neuromyotoxicity
Baker, S. K., & Tarnopolsky, M. A. (2005) · Drugs of Today · doi:10.1358/dot.2005.41.4.908565 · Cited by 42 · see citing works
Effects of mevinolin treatment on tissue dolichol and ubiquinone levels in the rat
Lőw, P., Andersson, M., Edlund, C., & Dallner, G. (1992) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(92)90081-6 · Cited by 42 · see citing works
Diebold, B. A., Bhagavan, N. V., & Guillory, R. J. (1994) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(94)90123-6 · Cited by 37 · see citing works
三宅, 豊. (1999) · Medical Entomology and Zoology · doi:10.11501/3176016 · Cited by 27 · see citing works
Sugiyama, S. (1998) · IUBMB Life · doi:10.1080/15216549800204472 · Cited by 23 · see citing works
Calişkan, S., Calişkan, M., Kuralay, F., & Önvural, B. (2000) · PubMed · Cited by 19 · see citing works
Young, J. M., Florkowski, C. M., Molyneux, S. L., et al. (2006) · Circulation · Cited by 4 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Kelly P, Vasu S, Getato M, McNurlan M, Lawson WE. Coenzyme Q10 improves myopathic pain in statin treated patients (abstr). J Am Coll Cardiol 2005;45:3A.
Cited by
Sorted by citations
Rosuvastatin in older patients with systolic heart failure
Kjekshus, J., Apetrei, E., Barrios, V., Böhm, M., Cleland, J. G. F., Cornel, J. H., Dunselman, P., Fonseca, C., Goudev, A., Grande, P., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa0706201 · Cited by 1,487 · see citing works
Stroes, E. S., Thompson, P. D., Corsini, A., Vladutiu, G. D., Raal, F. J., Ray, K. K., Roden, M., Stein, E., Tokgözoğlu, L., Nordestgaard, B. G., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv043 · Cited by 1,443 · see citing works
Self-citationAn assessment by the statin muscle safety task force: 2014 update
Rosenson, R. S., Baker, S. K., Jacobson, T. A., Kopecky, S. L., & Parker, B. A. (2014) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2014.03.004 · Cited by 485 · see citing works
Acid-suppressive medication use and the risk for hospital-acquired pneumonia
Herzig, S. J. (2009) · JAMA · doi:10.1001/jama.2009.722 · Cited by 486 · see citing works
Narrative review: statin-related myopathy
Joy, T. R., & Hegele, R. A. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-150-12-200906160-00009 · Cited by 453 · see citing works
Red Yeast Rice for Dyslipidemia in Statin-Intolerant Patients: A Randomized Trial
Becker, D. J., Gordon, R. Y., Halbert, S. C., French, B., Morris, P. B., & Rader, D. J. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-150-12-200906160-00006 · Cited by 275 · see citing works
Coenzyme Q10 supplementation: Efficacy, safety, and formulation challenges
Arenas‐Jal, M., Suñé‐Negre, J. M., & García‐Montoya, E. (2020) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12539 · Cited by 239 · see citing works
Human skeletal muscle drug transporters determine local exposure and toxicity of statins
Knauer, M. J., Urquhart, B. L., Meyer zu Schwabedissen, H. E., Schwarz, U. I., Lemke, C. J., Leake, B. F., Kim, R. B., & Tirona, R. G. (2010) · Circulation Research · doi:10.1161/circresaha.109.203596 · Cited by 222 · see citing works
A randomized trial of Coenzyme Q10 in patients with confirmed statin myopathy
Taylor, B. A., Lorson, L., White, C. M., & Thompson, P. D. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.12.016 · Cited by 200 · see citing works
Self-citationEffects of Coenzyme Q10 on Statin-Induced Myopathy
Banach, M., Serban, C., Sahebkar, A., Ursoniu, S., Rysz, J., Muntner, P., Toth, P. P., Jones, S. R., Rizzo, M., Glasser, S. P., et al. (2015) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2014.08.021 · Cited by 198 · see citing works
Banach, M., Serban, C., Ursoniu, S., Rysz, J., Muntner, P., Toth, P. P., Jones, S. R., Rizzo, M., Glasser, S. P., Watts, G. F., et al. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.07.008 · Cited by 195 · see citing works
Qu, H., Guo, M., Chai, H., Wang, W., Gao, Z., & Shi, D. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.118.009835 · Cited by 178 · see citing works
“one possible mechanism is mitochondrial dysfunction resulting from a reduction in circulating/intramuscular CoQ10.(3,4) The RCT results demonstrated that statins reduced circulating CoQ10 by 16% to 54%; a meta-analysis(6) of 6 RCTs also suggested a significant reduction in plasma CoQ10 after statin treatment, regardle…”
BackgroundInfluentialKwak, H.-B., Thalacker-Mercer, A., Anderson, E. J., Lin, C.-T., Kane, D. A., Lee, N.-S., Cortright, R. N., Bamman, M. M., & Neufer, P. D. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.10.449 · Cited by 114 · see citing works
Ahmad, Z. (2014) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2014.02.033 · Cited by 110 · see citing works
Statin myotoxicity: a review of genetic susceptibility factors
Needham, M., & Mastaglia, F. L. (2014) · Neuromuscular Disorders · doi:10.1016/j.nmd.2013.09.011 · Cited by 108 · see citing works
Effect of Coenzyme Q10 supplementation on statin-induced myalgias
Bookstaver, D. A., Burkhalter, N. A., & Hatzigeorgiou, C. (2012) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2012.04.026 · Cited by 89 · see citing works
Muntean, D. M., Thompson, P. D., Catapano, A. L., Stasiolek, M., Fabis, J., Muntner, P., Serban, M.-C., & Banach, M. (2017) · Drug Discovery Today · doi:10.1016/j.drudis.2016.09.001 · Cited by 82 · see citing works
Butterfield, D. A., Barone, E., & Mancuso, C. (2011) · Pharmacological Research · doi:10.1016/j.phrs.2011.04.007 · Cited by 80 · see citing works
“been seriously studied in relation to statin treatment: statins decrease CoQ10 levels in plasma and tissue, which may be responsible for several of statins’ side effects [11,12].”
BackgroundŠabovič, M. (2014) · Medical Science Monitor · doi:10.12659/msm.890777 · Cited by 75 · see citing works
Curcumin: an effective adjunct in patients with statin-associated muscle symptoms?
Sahebkar, A., Saboni, N., Pirro, M., & Banach, M. (2017) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12140 · Cited by 72 · see citing works
Mechanisms of statin-induced myalgia assessed by physiogenomic associations
Ruaño, G., Windemuth, A., Wu, A. H. B., Kane, J. P., Malloy, M. J., Pullinger, C. R., Kocherla, M., Bogaard, K., Gordon, B. R., Holford, T. R., et al. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.07.007 · Cited by 66 · see citing works
Self-citationClinical characterization and molecular mechanisms of statin myopathy
Toth, P. P., Harper, C. R., & Jacobson, T. A. (2008) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.6.7.955 · Cited by 55 · see citing works
Marcheggiani, F., Cirilli, I., Orlando, P., Silvestri, S., Vogelsang, A., Knott, A., Blatt, T., Weise, J. M., & Tiano, L. (2019) · Aging · doi:10.18632/aging.101926 · Cited by 53 · see citing works
Anti-ageing effects of ubiquinone and ubiquinol in a senescence model of human dermal fibroblasts
Marcheggiani, F., Kordes, S., Cirilli, I., Orlando, P., Silvestri, S., Vogelsang, A., Möller, N., Blatt, T., Weise, J. M., Damiani, E., et al. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.01.032 · Cited by 48 · see citing works
Shetty, R. A., Forster, M. J., & Sumien, N. (2013) · AGE · doi:10.1007/s11357-012-9484-9 · Cited by 47 · see citing works
Prolonged Intake of Coenzyme Q10 Impairs Cognitive Functions in Mice
Sumien, N., Heinrich, K. R., Shetty, R. A., Sohal, R. S., & Forster, M. J. (2009) · The Journal of Nutrition · doi:10.3945/jn.109.110437 · Cited by 46 · see citing works
Nash, M. S., Cowan, R. E., & Kressler, J. (2012) · The Journal of Spinal Cord Medicine · doi:10.1179/2045772312y.0000000034 · Cited by 45 · see citing works
Effects of widely used drugs on micronutrients: A story rarely told
Samaras, D., Samaras, N., Lang, P.-O., Genton, L., Frangos, E., & Pichard, C. (2013) · Nutrition · doi:10.1016/j.nut.2012.11.011 · Cited by 36 · see citing works
Deichmann, R. E., Lavie, C. J., & Dornelles, A. C. (2012) · The Physician and Sportsmedicine · doi:10.3810/psm.2012.11.1991 · Cited by 35 · see citing works
Atorvastatin-induced cell toxicity in yeast is linked to disruption of protein isoprenylation
Callegari, S., McKinnon, R. A., Andrews, S., & de Barros Lopes, M. A. (2010) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2009.00593.x · Cited by 28 · see citing works
Effect of Coenzyme Q<sub>10</sub>Supplementation in Statin-Treated Obese Rats
Choi, H.-K., Won, E.-K., & Choung, S.-Y. (2016) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2015.089 · Cited by 24 · see citing works
- Authors
- Marcoff, L., & Thompson, P. D.
- Affiliations
- Yale University (US)
- Hartford Hospital (US)
- Corresponding author
- Thompson, Paul D.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2007-06
- Volume
- 49
- Issue
- 23
- Pages
- 2231-2237
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W1701273068
- Cited by
- 537
- References
- 48
- Citations by year
- 2026: 10 · 2025: 15 · 2024: 27 · 2023: 22 · 2022: 10 · 2021: 22 · 2020: 18 · 2019: 18 · 2018: 29 · 2017: 27 · 2016: 28 · 2015: 39 · 2014: 47 · 2013: 32 · 2012: 32
- FWCI
- 2.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- coenzyme Q10, statin-induced myopathy, statins, ubiquinone deficiency, farnesyl pyrophosphate, mitochondrial function, coenzyme Q10 supplementation
- MeSH terms
- Coenzymes, Humans, Mitochondria, Cardiomyopathies, Ubiquinone, Muscle, Skeletal, Hydroxymethylglutaryl-CoA Reductase Inhibitors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
