The DOI matches its Crossref record; 150 of the 150 references it cites were found in a registry or an index.
Chlorogenic acid: A comprehensive review of the dietary sources, processing effects, bioavailability, beneficial properties, mechanisms of action, and future directions
Abstract
Chlorogenic acids (CGAs), a group of hydroxycinnamates, are generally abundant in everyday foods and beverages, most prominently in certain coffee drinks. Among them, the chlorogenic acid (CGA), also termed as 5‐ O ‐caffeoylquinic acid (5‐CQA), is one of the most abundant, highly functional polyphenolic compounds in the human diet. The evidence of its health benefits obtained from clinical studies, as well as basic research, indicates an inverse correlation between 5‐CQA consumption and a lower risk of metabolic syndromes and chronic diseases. This review focuses on the beneficial properties for health and mechanisms of action of 5‐CQA, starting with its history, isomers, dietary sources, processing effects, preparation methods, pharmacological safety evaluation, and bioavailability. It also provides the possible molecular mechanistic bases to explain the health beneficial effects of 5‐CQA including neuroprotective, cardiovascular protective, gastrointestinal protective, renoprotective, hepatoprotective, glucose and lipid metabolism regulatory, and anticarcinogenic effects. The information summarized here could aid in the basic and clinical research on 5‐CQA as a natural dietary additive, potential drug candidate, as well as a natural health promoter.
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1 retracted
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RetractedDiabetes and Atherosclerosis: Epidemiology, Pathophysiology, and Management
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Chlorogenic acid (CGA): A pharmacological review and call for further research
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Chlorogenic Acid and Caffeic Acid Are Absorbed in Humans
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In vitro and in vivo antioxidant properties of chlorogenic acid and caffeic acid
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PSYCHOSOCIAL FACTORS AND CARDIOVASCULAR DISEASES
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Role of Chlorogenic Acids in Controlling Oxidative and Inflammatory Stress Conditions
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Cited by
Quality structural annotation for the metabolites of chlorogenic acid in rat
Liu, W., Li, W., Zhang, P., Gong, X., Tu, P., Tang, L., Li, J., & Song, Y. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.132134 · Cited by 43
Cardullo, N., Floresta, G., Rescifina, A., Muccilli, V., & Tringali, C. (2021) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2021.105458 · Cited by 33
Xiao, Y., Shi, Y., Zhang, J., Xu, N., Liu, C., Zhang, C., Gao, X., Zhou, X., & Qin, K. (2026) · Phytochemistry Reviews · doi:10.1007/s11101-026-10280-4 · Cited by 1
Qu, Y., Wu, L., Wang, Y., Peng, F., Zhang, J., Pan, D., Wang, T., Zhou, Y., Xia, J., He, J., et al. (2026) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2026.06.041
Metadata
- Authors
- Lu, H., Tian, Z., Cui, Y., Liu, Z., & Ma, X.
- Venue
- Comprehensive Reviews in Food Science and Food Safety
- Publisher
- Wiley
- Published
- 2020-09-04
- Volume
- 19
- Issue
- 6
- Pages
- 3130-3158
- ISSN
- 1541-4337 (ISSN-L)
- OpenAlex
- W3083314342
- Cited by
- 448
- References
- 150
- FWCI
- 21.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lu, H., Tian, Z., Cui, Y., Liu, Z., & Ma, X. (2020). Chlorogenic acid: A comprehensive review of the dietary sources, processing effects, bioavailability, beneficial properties, mechanisms of action, and future directions. Comprehensive Reviews in Food Science and Food Safety. https://doi.org/10.1111/1541-4337.12620
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