The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Chlorogenic Acid: Recent Advances on Its Dual Role as a Food Additive and a Nutraceutical against Metabolic Syndrome
Open accessAbstract
Chlorogenic acid (5-O-caffeoylquinic acid) is a phenolic compound from thehydroxycinnamic acid family. This polyphenol possesses many health-promoting properties, mostof them related to the treatment of metabolic syndrome, including anti-oxidant, anti-inflammatory,antilipidemic, antidiabetic, and antihypertensive activities. The first part of this review will discussthe role of chlorogenic acid as a nutraceutical for the prevention and treatment of metabolicsyndrome and associated disorders, including in vivo studies, clinical trials, and mechanisms ofaction. The second part of the review will be dealing with the role of chlorogenic acid as a foodadditive. Chlorogenic acid has shown antimicrobial activity against a wide range of organisms,including bacteria, yeasts, molds, viruses, and amoebas. These antimicrobial properties can beuseful for the food industry in its constant search for new and natural molecules for thepreservation of food products. In addition, chlorogenic acid has antioxidant activity, particularlyagainst lipid oxidation; protective properties against degradation of other bioactive compoundspresent in food, and prebiotic activity. The combination of these properties makes chlorogenic acidan excellent candidate for the formulation of dietary supplements and functional foods.
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Cites
1 retracted
A comprehensive review on metabolic syndrome
Kaur, J. (2014) · Cardiology Research and Practice · doi:10.1155/2014/943162 · Cited by 1,889
RetractedIncreased oxidative stress in obesity and its impact on metabolic syndrome
Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., Nakayama, O., Makishima, M., Matsuda, M., & Shimomura, I. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21625 · Cited by 5,508
Metabolic syndrome: definitions and controversies
Kassi, E., Pervanidou, P., Kaltsas, G., & Chrousos, G. (2011) · BMC Medicine · doi:10.1186/1741-7015-9-48 · Cited by 1,565 · cited 3×
“Its components include dyslipidemia (elevated plasma total cholesterol, low-density lipoproteins (LDL), and triglycerides, and low levels of high-density lipoproteins (HDL)), high blood pressure, high fasting blood glucose levels, insulin resistance, chronic proinflammatory and prothrombotic states, non-alcoholic fatt…”
BackgroundInfluentialChronic Inflammation in Obesity and the Metabolic Syndrome
Monteiro, R., & Azevedo, I. (2010) · Mediators of Inflammation · doi:10.1155/2010/289645 · Cited by 1,186 · cited 2×
“A so, chronic inflammation has bee associated with metabolic syndrome [57].”
BackgroundChlorogenic Acid and Caffeic Acid Are Absorbed in Humans
Olthof, M. R., Katan, M. B., & Hollman, P. C. H. (2001) · The Journal of Nutrition · doi:10.1093/jn/131.1.66 · Cited by 975
Johnston, K. L., Clifford, M. N., & Morgan, L. M. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.4.728 · Cited by 590 · cited 1×
“[48] assessed the antidiabetic effects of dietary amounts of total CGAs in coffee.”
BackgroundChlorogenic Acid, Quercetin-3-Rutinoside and Black Tea Phenols Are Extensively Metabolized in Humans
Olthof, M. R., Hollman, P. C. H., Buijsman, M. N. C. P., van Amelsvoort, J. M. M., & Katan, M. B. (2003) · The Journal of Nutrition · doi:10.1093/jn/133.6.1806 · Cited by 468 · cited 1×
“Only about one-third of the ingested chlorogenic acid is absorbed from the small intestine into the bloodstream in humans, while the rest reaches the colon and it is extensively metabolized by the colonic microbiota, resulting in compounds such as hippuric acid, caffeic acid, and ferulic acid [58,64].”
Backgroundvan Dijk, A. E., Olthof, M. R., Meeuse, J. C., Seebus, E., Heine, R. J., & van Dam, R. M. (2009) · Diabetes Care · doi:10.2337/dc09-0207 · Cited by 293
Handbook of Functional Beverages and Human Health
(2016) · doi:10.1201/b19490 · Cited by 92
Cited by
Chlorogenic acid (CGA): A pharmacological review and call for further research
Naveed, M., Hejazi, V., Abbas, M., Kamboh, A. A., Khan, G. J., Shumzaid, M., Ahmad, F., Babazadeh, D., FangFang, X., Modarresi-Ghazani, F., et al. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.10.064 · Cited by 1,586
Antibacterial Activity of Some Flavonoids and Organic Acids Widely Distributed in Plants
Adamczak, A., Ożarowski, M., & Karpiński, T. M. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm9010109 · Cited by 478
dos S. Baião, D., da Silva, D. V. T., & Paschoalin, V. M. F. (2020) · Antioxidants · doi:10.3390/antiox9100960 · Cited by 102
Mortelé, O., Jörissen, J., Spacova, I., Lebeer, S., van Nuijs, A. L. N., & Hermans, N. (2021) · Food & Function · doi:10.1039/d0fo02629h · Cited by 53
Yang, F., Guang, C., Chen, H., & Hou, H. (2026) · Molecules · doi:10.3390/molecules31183247
Metadata
- Authors
- Santana-Gálvez, J., Cisneros-Zevallos, L., & Jacobo-Velázquez, D.
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2017-02-26
- Volume
- 22
- Issue
- 3
- Pages
- 358
- ISSN
- 1420-3049 (ISSN-L)
- OpenAlex
- W2592338368
- Cited by
- 721
- References
- 9
- FWCI
- 25.51
- Type
- journal article
- Language
- en
- Open access
- gold
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