The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Role of Chlorogenic Acids in Controlling Oxidative and Inflammatory Stress Conditions
Open accessAbstract
Chlorogenic acids (CGAs) are esters formed between caffeic and quinic acids, and represent an abundant group of plant polyphenols present in the human diet. CGAs have different subgroups that include caffeoylquinic, p-coumaroylquinic, and feruloyquinic acids. Results of epidemiological studies suggest that the consumption of beverages such as coffee, tea, wine, different herbal infusions, and also some fruit juices is linked to reduced risks of developing different chronic diseases. These beverages contain CGAs present in different concentrations and isomeric mixtures. The underlying mechanism(s) for specific health benefits attributed to CGAs involves mitigating oxidative stress, and hence the related adverse effects associated with an unbalanced intracellular redox state. There is also evidence to show that CGAs exhibit anti-inflammatory activities by modulating a number of important metabolic pathways. This review will focus on three specific aspects of the relevance of CGAs in coffee beverages; namely: (1) the relative composition of different CGA isomers present in coffee beverages; (2) analysis of in vitro and in vivo evidence that CGAs and individual isomers can mitigate oxidative and inflammatory stresses; and (3) description of the molecular mechanisms that have a key role in the cell signaling activity that underlines important functions.
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Cites
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Chlorogenic Acids from Green Coffee Extract Are Highly Bioavailable in Humans
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“In addition to 5-CQA, green coffee beans contain 3- and 4-CGA, dicaffeolyquinic acids (3,4-, 3,5-, and 4,5-diCQA), feruloylquinic acids (3-, 4-, and 5-FQA), and p-coumaroylquinic (3-p-, 4-p-, and 5-p-CoQA) acids [9].”
BackgroundInfluentialEffect of Roasting on the Formation of Chlorogenic Acid Lactones in Coffee
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“The scopolamine-induced amnesic mouse, an animal model to study Alzheimer’s disease, has produced data to show that 5-CQA decreased the MDA level in both the frontal cortex and the hippocampus of scopolamine-induced anemia in mice [71].”
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Variations in Caffeine and Chlorogenic Acid Contents of Coffees: What Are We Drinking?
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Stunting in childhood: an overview of global burden, trends, determinants, and drivers of decline
Vaivada, T., Akseer, N., Akseer, S., Somaskandan, A., Stefopulos, M., & Bhutta, Z. A. (2020) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa159 · Cited by 381
Food as medicine: targeting the uraemic phenotype in chronic kidney disease
Mafra, D., Borges, N. A., Lindholm, B., Shiels, P. G., Evenepoel, P., & Stenvinkel, P. (2021) · Nature Reviews Nephrology · doi:10.1038/s41581-020-00345-8 · Cited by 238
Amato, A., Terzo, S., & Mulè, F. (2019) · Antioxidants · doi:10.3390/antiox8120608 · Cited by 107
Characterization and comparison of cold brew and cold drip coffee extraction methods
Angeloni, G., Guerrini, L., Masella, P., Innocenti, M., Bellumori, M., & Parenti, A. (2019) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.9200 · Cited by 107
dos S. Baião, D., da Silva, D. V. T., & Paschoalin, V. M. F. (2020) · Antioxidants · doi:10.3390/antiox9100960 · Cited by 102
Metadata
- Authors
- Liang, N., & Kitts, D.
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2015-12-25
- Volume
- 8
- Issue
- 1
- Pages
- 16
- ISSN
- 2072-6643 (ISSN-L)
- OpenAlex
- W2216606325
- Cited by
- 805
- References
- 14
- FWCI
- 21.78
- Type
- journal article
- Language
- en
- Open access
- gold
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