Efficacy and safety of fecal microbiota transplantation for treating patients with ulcerative colitis: A systematic review and meta-analysis
Abstract
Objectives To assess the effect of donor selection, stool procedures and pretreatment with antibiotics on the efficacy and safety of fecal microbiota transplantation (FMT)‐treated ulcerative colitis (UC). Methods A systematic review and meta‐analysis was conducted including studies on UC treated with FMT as the primary therapeutic agent published up to June 30, 2020. Primary end‐point data included clinical remission (CR) or CR combined with endoscopic remission. Results A total of 37 studies (seven random controlled trials [RCTs], five controlled and 25 uncontrolled cohort studies) and 959 patients with UC were enrolled. In controlled cohort studies and RCTs, FMT had a significantly greater benefit than placebo (pooled odds ratio [P‐OR] 3.392, 95% CI 2.196‐5.240, P < 0.001), with no heterogeneity (I2 = 0%). Furthermore, administration of FMT via the lower gastrointestinal (GI) tract was more effective in achieving CR than via the upper GI tract (44.3% vs 31.7%). The remission rate was also higher when the total stool dosage was over 275 g compared with less than 275 g (51.9% vs 29.5%). Overall, the incidence of serious adverse events of FMT was 5.9%. There was no significant difference between single and multiple donors, fresh and frozen stool sample used, and whether or not antibiotic pretreatment was administered before FMT. Conclusion FMT administration via the lower GI tract and using higher dosage appear to be effective and safe in inducing remission of active UC.
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After positive outcomes for CDI, FMT has been investigated for a number of chronic disorders associated with dysbiosis, including inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), metabolic syndrome (MetS), neuropsychiatric disorders, and others.
“After positive outcomes for CDI, FMT has been investigated for a number of chronic disorders associated with dysbiosis, including inflammatory bowel disease (IBD), 35 irritable bowel syndrome (IBS), 36 metabolic syndrome (MetS), 37 neuropsychiatric disorders, 38 andothers.”
From Key determinants of success in fecal microbiota transplantation: From microbiome to clinic (2023) · cites this paper as [35]
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RETRACTED ARTICLE: Role of the gut microbiome in chronic diseases: a narrative review
Vijay, A., & Valdes, A. M. (2022) · European Journal of Clinical Nutrition · doi:10.1038/s41430-021-00991-6 · Cited by 361 · see citing works
Retracted
- Authors
- Zhao, H. L., Chen, S. Z., Xu, H. M., Zhou, Y. L., He, J., Huang, H. L., Xu, J., & Nie, Y. Q.
- Affiliations
- Guangzhou First People's Hospital (CN)
- Corresponding author
- Nie, Yu Qiang
- Venue
- Journal of Digestive Diseases
- Publisher
- Wiley
- Published
- 2020-10
- Volume
- 21
- Issue
- 10
- Pages
- 534-548
- ISSN
- 1751-2972 (ISSN-L)
- 1751-2980
- OpenAlex
- W3037354716
- Cited by
- 48
- References
- 51
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 10 · 2023: 8 · 2022: 8 · 2021: 6 · 2020: 1
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Digestive Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Surgery › Anorectal Disease Treatments and Outcomes
- Keywords
- fecal microbiota transplantation, ulcerative colitis, clinical remission, endoscopic remission, donor selection, antibiotic pretreatment, adverse events
- MeSH terms
- Fecal Microbiota Transplantation, Colitis, Ulcerative, Humans, Remission Induction, Randomized Controlled Trials as Topic, Treatment Outcome, Controlled Clinical Trials as Topic
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