Donor species richness determines faecal microbiota transplantation success in inflammatory bowel disease
Open accessAbstract
BACKGROUND AND AIMS: Faecal microbiota transplantation is a successful therapy for patients with refractory Clostridium difficile infections. It has also been suggested as a treatment option for inflammatory bowel disease, given the role of the intestinal microbiota in this disease. We assessed the impact of faecal microbiota transplantation in patients with inflammatory bowel disease and studied predictors of clinical (non-)response in microbial profiles of donors and patients. METHODS: Fourteen refractory patients (8 with ulcerative colitis and 6 with Crohn's disease) underwent ileocolonoscopy with faecal microbiota transplantation through a nasojejunal (n = 9) or rectal (n = 5) tube. Efficacy was assessed by endoscopic healing at week 8, clinical activity scores and C-reactive protein measurement. Faecal microbiota was analysed by 16S rDNA pyrosequencing. RESULTS: There was no significant improvement among the 6 patients with Crohn's disease at week 8 following faecal microbiota transplantation. One patient experienced temporary clinical remission for 6 weeks. In contrast, 2/8 patients with ulcerative colitis had endoscopic remission at week 8, and of the 6 remaining patients with ulcerative colitis, 1 reported temporary remission for 6 weeks. The donor microbiota richness and the number of transferred phylotypes were associated with treatment success. Persistent increased C-reactive protein 2 weeks after transplantation was predictive of failure of response. CONCLUSION: Faecal microbiota transplantation led to endoscopic and long-term (>2 years) remission in 2 out of 8 ulcerative colitis patients. Higher donor richness was associated with successful transplant. Therefore, faecal microbiota transplantation with donor prescreening could be a treatment option for selected refractory ulcerative colitis patients.
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Higher donor richness was repeatedly associated with the clinical success of FMT in a nonrandomized cohort of patients with IBD refractory to medical therapy.
“Higher donor richness was repeatedly associated with the clinical success of FMT in a nonrandomized cohort of patients with IBD refractory to medical therapy. 54,55”
From Key determinants of success in fecal microbiota transplantation: From microbiome to clinic (2023) · cites this paper as [54]
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- Authors
- Vermeire, S., Joossens, M., Verbeke, K., Wang, J., Machiels, K., Sabino, J., Ferrante, M., Van Assche, G., Rutgeerts, P., & Raes, J.
- Affiliations
- Vrije Universiteit Brussel (BE)
- KU Leuven (BE)
- VIB-KU Leuven Center for Microbiology (BE)
- ORCID
- Venue
- Journal of Crohn s and Colitis
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-10-29
- Volume
- 10
- Issue
- 4
- Pages
- 387-394
- ISSN
- 1873-9946 (ISSN-L)
- 1876-4479
- PMC
- PMC4946755
- OpenAlex
- W2288187473
- Cited by
- 311
- References
- 50
- Citations by year
- 2026: 8 · 2025: 16 · 2024: 26 · 2023: 26 · 2022: 36 · 2021: 29 · 2020: 46 · 2019: 39 · 2018: 31 · 2017: 30 · 2016: 23
- FWCI
- 19.16
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Crohn s and Colitis (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Lirias (KU Leuven) (submittedVersion)
- HighWire Press Open Archive (submittedVersion)
- VUBIR (Vrije Universiteit Brussel) (submittedVersion)
- Funders
- Fonds Wetenschappelijk Onderzoek
- KU Leuven
- Vlaamse regering
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Microscopic Colitis
- Keywords
- fecal microbiota transplantation, inflammatory bowel disease
- MeSH terms
- Gastrointestinal Microbiome, Fecal Microbiota Transplantation, Adult, C-Reactive Protein, Colitis, Ulcerative, Colonoscopy, Crohn Disease, Female, Humans, Male, Middle Aged, Inflammatory Bowel Diseases, Treatment Outcome, Treatment Failure
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