Endocrine‐disrupting chemicals, risk of type 2 diabetes, and diabetes‐related metabolic traits: A systematic review and meta‐analysis: 内分泌干扰物、2型糖尿病危险因素以及糖尿病相关代谢特征:一项系统回顾与meta分析
Abstract
Background: Elevated blood or urinary concentrations of endocrine‐disrupting chemicals (EDCs) may be related to increased risk of type 2 diabetes (T2D). The aim of the present study was to assess the role of EDCs in affecting risk of T2D and related metabolic traits. Methods: MEDLINE was searched for cross‐sectional and prospective studies published before 8 M arch 2014 into the association between EDCs (dioxin, polychlorinated biphenyl [PCB], chlorinated pesticide, bisphenol A [BPA], phthalate) and T2D and related metabolic traits. Three investigators independently extracted information on study design, participant characteristics, EDC types and concentrations, and association measures. Results: Forty‐one cross‐sectional and eight prospective studies from ethnically diverse populations were included in the analysis. Serum concentrations of dioxins, PCBs, and chlorinated pesticides were significantly associated with T2D risk; comparing the highest to lowest concentration category, the pooled relative risks (RR) were 1.91 (95% confidence interval [CI] 1.44–2.54) for dioxins, 2.39 (95% CI 1.86–3.08) for total PCBs, and 2.30 (95% CI 1.81–2.93) for chlorinated pesticides. Urinary concentrations of BPA and phthalates were also associated with T2D risk; comparing the highest to lowest concentration categories, the pooled RR were 1.45 (95% CI 1.13–1.87) for BPA and 1.48 (95% CI 0.98–2.25) for phthalates. Further, EDC concentrations were associated with indicators of impaired fasting glucose and insulin resistance. Conclusions: Persistent and non‐persistent EDCs may affect the risk of T2D. There is an urgent need for further investigation of EDCs, especially non‐persistent ones, and T2D risk in large prospective studies.
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- Authors
- Song, Y., Chou, E. L., Baecker, A., You, N. Y., Song, Y., Sun, Q., & Liu, S.
- Affiliations
- University of California, Los Angeles (US)
- Massachusetts General Hospital (US)
- Brigham and Women's Hospital (US)
- Brown University (US)
- Corresponding author
- Liu, Simin
- Venue
- Journal of Diabetes
- Publisher
- Wiley
- Published
- 2015-09
- Volume
- 8
- Issue
- 4
- Pages
- 516-532
- ISSN
- 1753-0393 (ISSN-L)
- 1753-0407
- OpenAlex
- W2166064032
- Cited by
- 228
- References
- 74
- Citations by year
- 2026: 10 · 2025: 17 · 2024: 26 · 2023: 21 · 2022: 23 · 2021: 22 · 2020: 24 · 2019: 26 · 2018: 22 · 2017: 20 · 2016: 14 · 2015: 3
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Burroughs Wellcome Fund
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
- Keywords
- endocrine disruptors, type 2 diabetes, dioxins, polychlorinated biphenyls, organochlorine pesticides, bisphenol A, phthalates, urinary biomarkers, serum concentration, insulin resistance, impaired fasting glucose, metabolic phenotypes
- MeSH terms
- Bisphenol A Compounds, Benzhydryl Compounds, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Dioxins, Humans, Phenols, Phthalic Acids, Polychlorinated Biphenyls, Prospective Studies, Risk Factors, Risk Assessment, Endocrine Disruptors
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