Personalized microbiome‐based approaches to metabolic syndrome management and prevention: 使用基于微生物的个体化治疗方法来管理与预防代谢综合征
Abstract
Personalized or precision medicine is a novel clinical approach targeted to the individual patient and based on integration of clinical, genetic, and environmental factors that define a patient uniquely from other individuals featuring similar clinical symptoms. Such a personalized medicine approach is increasingly applied for diagnosis, clinical stratification, and treatment of metabolic syndrome (MetS)-associated risks and diseases, including obesity, type 2 diabetes, non-alcoholic fatty liver disease, and their complications. One emerging factor that governs MetS manifestations is the microbiome, the composition, function, growth dynamics, associated metabolite profile and diverse effects of which on host immune and metabolic systems can all significantly affect metabolic homeostasis. Interindividual differences in microbiome composition and function, as well as personal variations in microbial-derived products, pave the way towards microbiome-based personalized medicine in treating MetS-related diseases.
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The gut microbiome can actively drive obesity, either together with diet and genetic predisposition or independently.
“Unexpectedly, the gut microbiome can be an active driver of obesity, either in combination with the interrelated factors of diet and genetic predisposition, or by itself (Cox and Blaser, 2013; Shapiro et al., 2017).”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Shapiro et al., 2017
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“Unexpectedly, the gutmicrobiome can be an active driver of obesity, either in combination with the interrelated factors of diet and genetic predisposition or by itself (Cox and Blaser, 2013; Shapiro et al., 2017).”
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- Authors
- Shapiro, H., Suez, J., & Elinav, E.
- Affiliations
- Weizmann Institute of Science (IL)
- Corresponding author
- Elinav, Eran
- Venue
- Journal of Diabetes
- Publisher
- Wiley
- Published
- 2017-02-02
- Volume
- 9
- Issue
- 3
- Pages
- 226-236
- ISSN
- 1753-0393 (ISSN-L)
- 1753-0407
- OpenAlex
- W2542071099
- Cited by
- 56
- References
- 21
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 3 · 2020: 12 · 2019: 6 · 2018: 6 · 2017: 5
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- metabolic syndrome, gut microbiota, personalized medicine, precision medicine, obesity, type 2 diabetes, non-alcoholic fatty liver disease, microbiota-based therapy, microbial metabolites, host-microbe interactions, metabolic homeostasis
- MeSH terms
- Gastrointestinal Microbiome, Diabetes Mellitus, Type 2, Feces, Humans, Obesity, Probiotics, Metabolic Syndrome, Prebiotics, Precision Medicine, Non-alcoholic Fatty Liver Disease
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