CCL 2, CXCL 8, CXCL 9 and CXCL 10 serum levels increase with age but are not altered by treatment with hydroxychloroquine in patients with osteoarthritis of the knees
Abstract
Aim: Osteoarthritis (OA) is a major cause of morbidity and incapacity in the elderly. This study evaluates serum levels of the chemokines CCL 2, CXCL 8, CXCL 9, and CXCL 10 in 16 patients with primary OA of the knees, and investigates how treatment with hydroxychloroquine (HCQ) for 4 months affects these chemokine levels. Method: Thirteen elderly patients received a placebo. Healthy control groups consisted of 10 elderly individuals (age > 60 years) with no clinical or radiological evidence of OA (CT‐O), and 10 young adult individuals, (CT‐Y group, age < 40 years). Results: The CT‐Y group presented lower levels of all chemokines studied, in comparison to the other groups. HCQ treatment did not alter the serum levels of CCL 2 (P = 0.80), CXCL 8 (P = 0.76), CXCL 9 (P = 0.95) and CXCL 10 (P = 0.74) in OA patients. Conclusion: Hydroxychloroquine treatment did not alter the serum levels of CCL 2, CXCL 8, CXCL 9 or CXCL 10 in patients with OA of the knees, although increased serum levels correlated with aging for all subjects, including controls.
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CXCL9 increases with age in humans.
“Some studies in humans have found CXCL9 to increase with age93–98”
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- Authors
- Bonfante, H. D. L., Almeida, C. D. S., Abramo, C., Grunewald, S. T. F., Levy, R. A., & Teixeira, H. C.
- Affiliations
- Universidade Federal de Juiz de Fora (BR)
- Department of Maternal and Child Health Faculty of Medicine Federal University of Juiz de Fora Juiz de Fora Minas Gerais Brazil
- Universidade do Estado do Rio de Janeiro (BR)
- Corresponding author
- Teixeira, Henrique Couto
- ORCID
- Venue
- International Journal of Rheumatic Diseases
- Publisher
- Wiley
- Published
- 2015-05-08
- Volume
- 20
- Issue
- 12
- Pages
- 1958-1964
- ISSN
- 1756-1841 (ISSN-L)
- 1756-185X
- OpenAlex
- W1526973257
- Cited by
- 33
- References
- 37
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 5 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 4 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 1 · 2015: 1
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Rheumatic Diseases (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais
- Topics
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Keywords
- knee osteoarthritis, chemokines, MCP-1, interleukin-8, CXCL9, CXCL10, hydroxychloroquine, serum concentration, aging, elderly patients, anti-inflammatory therapy
- MeSH terms
- Age Factors, Aged, Aging, Female, Humans, Hydroxychloroquine, Male, Middle Aged, Time Factors, Biomarkers, Up-Regulation, Case-Control Studies, Interleukin-8, Treatment Outcome, Antirheumatic Agents, Chemokine CCL2, Osteoarthritis, Knee, Chemokine CXCL10, Chemokine CXCL9
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