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Cell‐free DNA as a biomarker of aging

Teo, Yee Voan, Capri, Miriam, Morsiani, Cristina, Pizza, Grazia, Faria, Ana Maria Caetano, Franceschi, Claudio, Neretti, Nicola·2019·Aging Cell
DOI 10.1111/acel.12890PMC PMC6351822
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Abstract

Cell‐free DNA (cfDNA) is present in the circulating plasma and other body fluids and is known to originate mainly from apoptotic cells. Here, we provide the first in vivo evidence of global and local chromatin changes in human aging by analyzing cfDNA from the blood of individuals of different age groups. Our results show that nucleosome signals inferred from cfDNA are consistent with the redistribution of heterochromatin observed in cellular senescence and aging in other model systems. In addition, we detected a relative cfDNA loss at several genomic locations, such as transcription start and termination sites, 5′UTR of L1HS retrotransposons and dimeric AluY elements with age. Our results also revealed age and deteriorating health status correlate with increased enrichment of signals from cells in different tissues. In conclusion, our results show that the sequencing of circulating cfDNA from human blood plasma can be used as a noninvasive methodology to study age‐associated changes to the epigenome in vivo.

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  1. 10.3390/ijms18050974 · DOI
  2. 10.1016/j.mad.2017.02.010 · DOI
  3. 10.1016/j.mad.2015.03.010 · DOI
  4. 10.1007/s10654-018-0364-1 · DOI
  5. 10.1101/gr.142067.112 · DOI
  6. 10.1159/000058351 · DOI
  7. 10.1038/nature11247 · DOI · Paper page
  8. 10.1186/1471-2164-15-583 · DOI
  9. 10.1073/pnas.1517494112 · DOI
  10. 10.1016/j.cels.2016.07.002 · DOI
  11. 10.1093/bib/bby029 · DOI
  12. 10.1093/gerona/glu057 · DOI · Paper page
  13. 10.1016/j.tem.2016.09.005 · DOI · Paper page
  14. 10.1371/journal.pgen.1000138 · DOI
  15. 10.1038/ng.3805 · DOI
  16. 10.18637/jss.v033.i02 · DOI
  17. 10.1111/acel.12325 · DOI
  18. 10.1101/gad.233221.113 · DOI
  19. 10.1186/1471-2164-16-S13-S1 · DOI
  20. 10.1016/j.cca.2010.07.032 · DOI · Paper page
  21. 10.1016/j.mad.2010.11.001 · DOI
  22. 10.1111/acel.12058 · DOI
  23. Ke W. L., 2015, Detection of fetal cell‐free DNA in maternal plasma for Down syndrome, Edward syndrome and Patau syndrome of high risk fetus, International Journal of Clinical and Experimental Medicine, 8, 9525
  24. 10.1038/nrneph.2014.185 · DOI
  25. 10.1152/ajprenal.00256.2017 · DOI
  26. 10.1038/nmeth.1923 · DOI · Paper page
  27. 10.1186/gb-2009-10-3-r25 · DOI · Paper page
  28. 10.1073/pnas.1519286113 · DOI
  29. 10.1038/nmeth.3104 · DOI
  30. 10.1371/journal.pone.0067156 · DOI
  31. Li H.(2013).Aligning sequence reads clone sequences and assembly contigs with BWA‐MEM. ArXiv e‐prints 1303. Retrieved fromhttp://adsabs.harvard.edu/abs/2013arXiv1303.3997L
  32. 10.1093/bioinformatics/btp352 · DOI · Paper page
  33. 10.1073/pnas.95.15.8461 · DOI
  34. 10.1126/scitranslmed.3001720 · DOI
  35. 10.1186/s13059-014-0550-8 · DOI · Paper page
  36. 10.1038/ncomms11485 · DOI
  37. 10.1016/j.bbagen.2016.01.013 · DOI
  38. 10.1074/jbc.M200742200 · DOI
  39. 10.1126/sciadv.1501332 · DOI
  40. 10.1038/nrg3663 · DOI
  41. 10.1093/gerona/gly194 · DOI
  42. 10.1111/j.1749-6632.2002.tb02086.x · DOI
  43. 10.1016/j.cell.2014.11.021 · DOI · Paper page
  44. 10.1016/j.cell.2008.02.022 · DOI
  45. 10.1016/j.cell.2015.11.050 · DOI
  46. 10.1128/MCB.21.6.1973-1985.2001 · DOI
  47. 10.1073/pnas.1508736112 · DOI
  48. 10.1128/MCB.10.12.6718 · DOI
  49. 10.1172/JCI105479 · DOI
  50. Taniuchi H., 1967, The amino acid sequence of an extracellular nuclease of Staphylococcus aureus. 3. Complete amino acid sequence, Journal of Biological Chemistry, 242, 4752, 10.1016/S0021-9258(18)99519-0 · DOI
  51. 10.1016/j.arr.2015.04.002 · DOI · Paper page
  52. 10.1038/nature10002 · DOI
  53. 10.1373/clinchem.2007.092734 · DOI
  54. 10.1016/j.jvs.2004.08.034 · DOI
  55. 10.1038/srep36097 · DOI
  56. 10.1186/gb-2008-9-9-r137 · DOI · Paper page

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Metadata

Authors
Teo, Y. V., Capri, M., Morsiani, C., Pizza, G., Faria, A. M. C., Franceschi, C., & Neretti, N.
Venue
Aging Cell
Publisher
Wiley
Published
2018-12-20
Volume
18
Issue
1
ISSN
  • 1474-9718
  • 1474-9726
DOI
10.1111/acel.12890
PMC
PMC6351822
Cited by
127
References
11
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
  • Università di Bologna (FARB2‐2014)
  • National Institute on Aging (R01AG050582‐01A1)

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