Cited by 31Neurogenesis and neuroplasticity mechanismsNeuroinflammation and Neurodegeneration MechanismsT-cell and B-cell Immunology

CD8+ T cells are increased in the subventricular zone with physiological and pathological aging

Open access
Moreno‐Valladares, Manuel, Moreno‐Cugnon, Leire, Silva, Tulio Mateo, Garcés, Juan Pablo, Saenz‐Antoñanzas, Ander, Álvarez‐Satta, María, Matheu, Ander·2020·Aging Cell

Abstract

Age‐related cognitive decline and neurodegenerative diseases are associated with less functional neurogenic niches. It has been recently shown that aged subventricular zone (SVZ) suffers an infiltration of T cells, which affects neural stem cell activity in mice. Whether this occurs in human neurogenic niches or to which extent T‐cell infiltration is also taking place in neurodegenerative diseases remains unknown. In this work, we studied the presence of T cells in both human neurogenic niches in young and old individuals. There was a significant increase in the number of CD3+ and CD8+ T cells in the SVZ of elderly individuals, which was not detected in the dentate gyrus. Moreover, we also found CD3+ and CD8+ T cells in the SVZ of individuals with neurodegenerative diseases. However, T‐cell count was similar when compared non‐neuropathological elderly with disease diagnosed patients. Our study reveals the infiltration of T cells in old human brains, particularly in the SVZ under non‐pathological conditions and also in neurodegenerative contexts.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1111/acel.13198

Cites

14 of 14 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Immunofluorescence staining confirmed the infiltration of T cells in the regenerative regions of aged mice and humans.

    “Immunofluorescence staining confirmed the infiltration of T cells in the regenerative regions of aged mice and humans7,70.”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Moreno‐Valladares, M., Moreno‐Cugnon, L., Silva, T. M., Garcés, J. P., Saenz‐Antoñanzas, A., Álvarez‐Satta, M., & Matheu, A.
Affiliations
  • Biogipuzkoa Health Research Institute (ES)
  • Donostiako Unibertsitate Ospitalea (ES)
  • Ikerbasque (ES)
Corresponding author
Matheu, Ander
Venue
Aging Cell
Publisher
Wiley
Published
2020-08
Volume
19
Issue
9
Pages
e13198-e13198
ISSN
  • 1474-9718 (ISSN-L)
  • 1474-9726
OpenAlex
W3046482607
Cited by
26
References
14
Citations by year
2026: 6 · 2025: 1 · 2024: 3 · 2023: 5 · 2022: 8 · 2021: 2 · 2020: 1
FWCI
2.07
Type
journal article
Language
en
Open access
Locations
  • Aging Cell (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
Instituto de Salud Carlos III (CP16/00039, DTS18/00181, PI16/01580, PI19/01355)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords
CD8+ T cells, subventricular zone, aging, T cell infiltration, neurogenic niche, neural stem cells, neurodegenerative diseases, age-related cognitive decline, dentate gyrus, human brain
MeSH terms
Aging, Humans, CD8-Positive T-Lymphocytes, Neural Stem Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review