Randomized controlled trial of multi‐modular motion‐assisted memory desensitization and reconsolidation (3MDR) for male military veterans with treatment‐resistant post‐traumatic stress disorder
Open accessAbstract
Objective: To explore the potential efficacy of multi‐modular motion‐assisted memory desensitization and reprocessing (3MDR) in British military veterans with treatment‐resistant service‐related PTSD. Methods: Exploratory single‐blind, randomized, parallel arm, cross‐over controlled trial with nested process evaluation to assess fidelity, adherence and factors that influence outcome. Results: A total of 42 participants (all male) were randomized with 83% retention at 12 weeks and 86% at 26 weeks. The difference in mean Clinician‐Administered PTSD Scale for DSM‐5 scores between the immediate and delayed 3MDR arms was −9.38 (95% CI −17.33 to −1.44, P = 0.021) at 12 weeks and −3.59 (−14.39 to 7.20, P = 0.513) at 26 weeks when both groups had received 3MDR. The likely effect size of 3MDR was found to be 0.65. Improvements were maintained at 26‐week follow‐up. 3MDR was found to be acceptable to most, but not all, participants. Several factors that may impact efficacy and acceptability of 3MDR were identified. Conclusion: 3MDR is a promising new intervention for treatment‐resistant PTSD with emerging evidence of effect.
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Digital health-based treatments are effective at reducing symptoms of PTSD and other mental health disorders caused by exposure to trauma.
“Current research indicates that these platforms are effective at reducing the symptoms of PTSD and other mental health disorders caused by exposure to trauma [28-32].”
From Efficacy, Effectiveness, and Quality of Resilience-Building Mobile Health Apps for Military, Veteran, and Public Safety Personnel Populations: Scoping Literature Review and App Evaluation (2022) · cites this paper as [29]
The Main results (page unavailable) report that 3MDR reduced PTSD symptoms in male military veterans with treatment-resistant PTSD, with positive effects on anxiety and insomnia symptoms. The paper evaluates one motion-assisted treatment, not digital health platforms generally, and does not establish effectiveness for other trauma-related mental health disorders. (LLM, conf=0.86)
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Cites
Using thematic analysis in psychology
Braun, V., & Clarke, V. (2006) · Qualitative Research in Psychology · doi:10.1191/1478088706qp063oa · Cited by 194,414 · see citing works
Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2013) · doi:10.1176/appi.books.9780890425596 · Cited by 116,369 · see citing works
The PHQ-9: Validity of a brief depression severity measure
Kroenke, K., Spitzer, R. L., & Williams, J. B. W. (2001) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.2001.016009606.x · Cited by 44,910 · see citing works
A Brief Measure for Assessing Generalized Anxiety Disorder: The GAD-7
Spitzer, R. L., Kroenke, K., Williams, J. B. W., & Löwe, B. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.10.1092 · Cited by 31,765 · see citing works
SAUNDERS, J. B., AASLAND, O. G., BABOR, T. F., DE LA FUENTE, J. R., & GRANT, M. (1993) · Addiction · doi:10.1111/j.1360-0443.1993.tb02093.x · Cited by 13,482 · see citing works
The development of a Clinician-Administered PTSD Scale
Blake, D. D., Weathers, F. W., Nagy, L. M., Kaloupek, D. G., Gusman, F. D., Charney, D. S., & Keane, T. M. (1995) · Journal of Traumatic Stress · doi:10.1002/jts.2490080106 · Cited by 5,024 · see citing works
Morin, C. M., Belleville, G., Bélanger, L., & Ivers, H. (2011) · Sleep · doi:10.1093/sleep/34.5.601 · Cited by 4,620 · see citing works
The Work and Social Adjustment Scale: a simple measure of impairment in functioning
Mundt, J. C., Marks, I. M., Shear, M. K., & Greist, J. M. (2002) · British Journal of Psychiatry · doi:10.1192/bjp.180.5.461 · Cited by 2,515 · see citing works
Dey, I. (2003) · Routledge eBooks · doi:10.4324/9780203412497 · Cited by 2,410 · see citing works
Janssen, M. F., Pickard, A. S., Golicki, D., Gudex, C., Niewada, M., Scalone, L., Swinburn, P., & Busschbach, J. (2013) · Quality of Life Research · doi:10.1007/s11136-012-0322-4 · Cited by 1,582 · see citing works
Psychometric properties of the PTSD checklist—civilian version
Ruggiero, K. J., Ben, K. D., Scotti, J. R., & Rabalais, A. E. (2003) · Journal of Traumatic Stress · doi:10.1023/a:1025714729117 · Cited by 1,227 · see citing works
Psychotherapy for Military-Related PTSD: A Review of Randomized Clinical Trials
Steenkamp, M. M., Litz, B. T., Hoge, C. W., & Marmar, C. R. (2015) · JAMA · doi:10.1001/jama.2015.8370 · Cited by 958 · see citing works
Life of the mind: The interface of psychopharmaceuticals, domestic economies, and social abandonment
Biehl, J. G. (2004) · American Ethnologist · doi:10.1525/ae.2004.31.4.475 · Cited by 903 · see citing works
Eye movement desensitization: A new treatment for post-traumatic stress disorder
Shapiro, F. (1989) · Journal of Behavior Therapy and Experimental Psychiatry · doi:10.1016/0005-7916(89)90025-6 · Cited by 812 · see citing works
Mithoefer, M. C., Mithoefer, A. T., Feduccia, A. A., Jerome, L., Wagner, M., Wymer, J., Holland, J., Hamilton, S., Yazar-Klosinski, B., Emerson, A., et al. (2018) · The Lancet Psychiatry · doi:10.1016/s2215-0366(18)30135-4 · Cited by 439 · see citing works
Raskind, M. A., Peterson, K. A., Williams, T., Hoff, D. J., Hart, K. L., Holmes, H. A., Homas, D., Hill, J., Daniels, C., Calohan, J., et al. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.12081133 · Cited by 356 · see citing works
CONSORT Revised—Improving the Reporting of Randomized Trials
Rennie, D. (2001) · JAMA · doi:10.1001/jama.285.15.2006 · Cited by 293 · see citing works
Stevelink, S. A. M., Jones, M., Hull, L., Pernet, D., MacCrimmon, S., Goodwin, L., MacManus, D., Murphy, D., Jones, N., Greenberg, N. L., et al. (2018) · The British Journal of Psychiatry · doi:10.1192/bjp.2018.175 · Cited by 241 · see citing works
Virtual reality exposure therapy for combat‐related posttraumatic stress disorder
ROTHBAUM, B. O., Rizzo, A., & Difede, J. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05691.x · Cited by 117 · see citing works
Kitchiner, N. J., Lewis, C., Roberts, N. P., & Bisson, J. I. (2019) · European Journal of Psychotraumatology · doi:10.1080/20008198.2019.1684226 · Cited by 113 · see citing works
Self-citationvan Gelderen, M. J., Nijdam, M. J., Haagen, J. F. G., & Vermetten, E. (2020) · Psychotherapy and Psychosomatics · doi:10.1159/000505977 · Cited by 59 · see citing works
Self-citationvan Gelderen, M. J., Nijdam, M. J., & Vermetten, E. H. G. J. M. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00176 · Cited by 57 · see citing works
Self-citationLewis, C., Roberts, N., Vick, T., & Bisson, J. I. (2013) · Depression and Anxiety · doi:10.1002/da.22128 · Cited by 28 · see citing works
Self-citationVermetten, E. H. G. J. M., Lydia, M., Peter, V. D. W., & Mert, A. (2013) · Studies in health technology and informatics · doi:10.3233/978-1-61499-282-0-125 · Cited by 26 · see citing works
Self-citationDahlem (1991) · doi:10.1002/1097-4679(199111)47:6
Flagged first, then by citations
Research works printed but not linked: 5
- Steenkamp M, Litz B, Hoge C, Marmar C. Psychotherapy for military-related PTSD. JAMA 2015;314:489-500.
- Kroenke K, Spitzer R, Williams J. The PHQ-9. J Gen Intern Med 2001;16:606-613.
- Spitzer R, Kroenke K, Williams J, L€ owe B. A brief measure for assessing generalized anxiety disorder. Arch Intern Med 2006;166:1092.
- Cohen J. Statistical power analysis for the behavioral sciences. Routledge; 1977.
- Higgins JP, Green S (Eds.). Cochrane Handbook for Sys- tematic Reviews of Interventions Version 5.1.0. The Cochrane Collaboration; 2011.
Cited by
Sorted by citations
Hoppen, T. H., Jehn, M., Holling, H., Mutz, J., Kip, A., & Morina, N. (2023) · Journal of Consulting and Clinical Psychology · doi:10.1037/ccp0000809 · Cited by 65 · see citing works
Voth, M., Chisholm, S., Sollid, H., Jones, C., Smith-MacDonald, L., & Brémault-Phillips, S. (2022) · JMIR mHealth and uHealth · doi:10.2196/26453 · Cited by 35 · see citing works
Jones, C., Miguel Cruz, A., Smith-MacDonald, L., Brown, M. R. G., Vermetten, E., & Brémault-Phillips, S. (2022) · JMIR Formative Research · doi:10.2196/33681 · Cited by 19 · see citing works
- Authors
- Bisson, J. I., van Deursen, R., Hannigan, B., Kitchiner, N., Barawi, K., Jones, K., Pickles, T., Skipper, J., Young, C., Abbott, L. R., van Gelderen, M., Nijdam, M. J., & Vermetten, E.
- Affiliations
- Cardiff University (GB)
- School of Healthcare Sciences Cardiff University Cardiff UK
- Cardiff and Vale University Health Board (GB)
- Department of Psychiatry Leiden University Medical Center Leiden The Netherlands
- Arq Psychotrauma Expert Group (NL)
- Leiden University Medical Center (NL)
- Corresponding author
- Bisson, J. I.
- ORCID
- Venue
- Acta Psychiatrica Scandinavica
- Publisher
- Wiley
- Published
- 2020-06-28
- Volume
- 142
- Issue
- 2
- Pages
- 141-151
- ISSN
- 0001-690X (ISSN-L)
- 1600-0447
- OpenAlex
- W3031746904
- Cited by
- 43
- References
- 25
- Citations by year
- 2026: 8 · 2025: 4 · 2024: 3 · 2023: 10 · 2022: 7 · 2021: 6 · 2020: 5
- FWCI
- 2.80
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Acta Psychiatrica Scandinavica (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (acceptedVersion)
- Leiden Repository (Leiden University) (submittedVersion, cc-by-nc-nd)
- Data Archiving and Networked Services (DANS) (submittedVersion, cc-by-nc-nd)
- Funders
- Forces in Mind Trust (Research Grant)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
- Keywords
- post-traumatic stress disorder, treatment-resistant PTSD, military veterans, EMDR, intervention fidelity, acceptability, process evaluation
- MeSH terms
- Adult, Humans, Male, Memory, Motion, Stress Disorders, Post-Traumatic, Veterans, Single-Blind Method, Treatment Outcome, Cross-Over Studies
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