Drug Addiction and Stress-Response Genetic Variability: Association Study in African Americans: Stress-Response Genes and Drug Addiction
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Stress is a significant risk factor in the development of drug addictions and in addiction relapse susceptibility. This hypothesis-driven study was designed to determine if specific SNPs in genes related to stress response are associated with heroin and/or cocaine addiction in African Americans. The analysis included 27 genes (124 SNPs) and was performed independently for each addiction. The sample consisted of former heroin addicts in methadone maintenance treatment (n = 314), cocaine addicts (n = 281), and controls (n = 208). Fourteen SNPs showed nominally significant association with heroin addiction (p < 0.05), including the African-specific, missense SNP rs5376 (Asn334Ser) in the galanin receptor type 1 gene (GALR1) and the functional FKBP5 intronic SNP rs1360780. Thirteen SNPs showed association with cocaine addiction, including the synonymous SNPs rs237902, in the oxytocin receptor gene (OXTR), and rs5374 in GALR1. No signal remained significant after correction for multiple testing. Four additional SNPs (GALR1 rs2717162, AVP rs2282018, CRHBP rs1875999, and NR3C2 rs1040288) were associated with both addictions and may indicate common liability. The study provides preliminary evidence for novel association of variants in several stress-related genes with heroin and/or cocaine addictions and may enhance the understanding of the interaction between stress and addictions.
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CRHBP gene polymorphisms are associated with risk of heroin addiction in African Americans and higher risk of drinking and/or anxiety in subjects with AUD.
“Polymorphisms of the CRF binding protein (CRHBP) gene have also been associated with the risk of both heroin addiction in African Americans (Levran et al., 2014) and a higher risk of drinking and/or anxiety in subjects with AUD (Haass-Koffler et al., 2016).”
From Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development (2021) · cites this paper as Levran et al., 2014
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- Authors
- Levran, O., Randesi, M., Li, Y., Rotrosen, J., Ott, J., Adelson, M., & Jeanne Kreek, M.
- Affiliations
- Rockefeller University (US)
- Shanxi University of Finance and Economics (CN)
- VA NY Harbor Healthcare System (US)
- Institute of Psychology; Chinese Academy of Sciences; Beijing China
- The Laboratory of the Biology of Addictive Diseases; The Rockefeller University; New York NY USA
- Corresponding author
- Levran, Orna
- Venue
- Annals of Human Genetics
- Publisher
- Wiley
- Published
- 2014-04-26
- Volume
- 78
- Issue
- 4
- Pages
- 290-298
- ISSN
- 0003-4800 (ISSN-L)
- PMC
- PMC4065216
- OpenAlex
- W2123358273
- Cited by
- 62
- References
- 55
- Citations by year
- 2025: 4 · 2024: 1 · 2023: 5 · 2022: 2 · 2021: 4 · 2020: 7 · 2019: 5 · 2018: 9 · 2017: 8 · 2016: 6 · 2015: 7 · 2014: 4
- FWCI
- 3.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of Human Genetics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Institutional Repository of Institute of Psychology, Chinese Academy of Sciences (Institute of Psychology, Chinese Academy of Sciences) (submittedVersion)
- Funders
- The Miriam and G. Sheldon Adelson Foundation (NA)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- drug addiction, heroin addiction, cocaine dependence, stress response genes, single nucleotide polymorphisms, genetic susceptibility, African Americans, methadone maintenance treatment, galanin receptor 1, oxytocin receptor, FKBP5, rs1360780, vasopressin, CRHBP, mineralocorticoid receptor, addiction relapse
- MeSH terms
- Black or African American, Female, Humans, Male, Stress, Physiological, Stress, Psychological, Case-Control Studies, Computational Biology, Substance-Related Disorders, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Genetic Association Studies
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