Genetic variations in genes of the stress response pathway are associated with prolonged abstinence from heroin
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AIM: This study assesses whether genetic variants in stress-related genes are associated with prolonged abstinence from heroin in subjects that are not in long-term methadone treatment. METHODS: Frequencies of 117 polymorphisms in 30 genes were compared between subjects with history of heroin addiction, either without agonist treatment (n = 129) or in methadone maintenance treatment (n = 923). RESULTS: SNP rs1500 downstream of CRHBP and an interaction of SNPs rs10482672 (NR3C1) and rs4234955 (NPY1R/NPY5R) were significantly associated with prolonged abstinence without agonist treatment. CONCLUSION: This study suggests that variability in stress-related genes may contribute to the ability of certain subjects to remain in prolonged abstinence from heroin, possibly due to higher resilience to stress.
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Variability in stress-related genes may contribute to the ability of certain individuals to remain abstinent from heroin, possibly due to higher stress resilience.
“It has also been suggested that variability in stress-related genes may contribute to the ability of certain individuals to remain abstinent from heroin, possibly due to higher stress resilience [180].”
From Food Addiction and Psychosocial Adversity: Biological Embedding, Contextual Factors, and Public Health Implications (2020) · cites this paper as [180]
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Levran, O., Li, J., Sason, A., Adelson, M., & Peles, E. (2026) · Epigenomes · doi:10.3390/epigenomes10020029
- Authors
- Levran, O., Peles, E., Randesi, M., Correa da Rosa, J., Shen, P.-H., Rotrosen, J., Adelson, M., & Kreek, M. J.
- Affiliations
- Rockefeller University (US)
- Tel Aviv University (IL)
- Center for Clinical & Translational Science, The Rockefeller University, New York, NY10065, USA
- National Institutes of Health (US)
- NYU Langone Health (US)
- Tel Aviv Sourasky Medical Center (IL)
- ORCID
- Venue
- Pharmacogenomics
- Publisher
- Informa UK Limited
- Published
- 2018-02-21
- Volume
- 19
- Issue
- 4
- Pages
- 333-341
- ISSN
- 1462-2416 (ISSN-L)
- 1744-8042
- PMC
- PMC5941712
- OpenAlex
- W2791459338
- Cited by
- 13
- References
- 54
- Citations by year
- 2026: 1 · 2023: 1 · 2022: 4 · 2021: 1 · 2020: 4 · 2019: 2
- FWCI
- 1.67
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Pharmacogenomics (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Dr Miriam and Sheldon G Adelson Medical Research Foundation
- Clinical and Translational Science (UL1RR024143)
- National Center for Advancing Translational Sciences of the NIH
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- heroin addiction, long-term abstinence, stress response genes, genetic polymorphism, methadone maintenance treatment, CRHBP, NR3C1, Y1 receptor, stress resilience, opioid use disorder
- MeSH terms
- Carrier Proteins, Heroin, Female, Genotype, Heroin Dependence, Humans, Male, Methadone, Stress, Psychological, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Opiate Substitution Treatment
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