Emerging role of interleukin‐31 and interleukin‐31 receptor in pruritus in atopic dermatitis
Open accessAbstract
Atopic dermatitis (AD) is a chronic or chronically relapsing, eczematous, severely pruritic skin disorder associated with skin barrier dysfunction. The lesional skin of AD exhibits T helper 2 (T H 2)‐deviated immune reactions. Interleukin‐31 (IL‐31), preferentially produced from T H 2 cells, is a potent pruritogenic cytokine, and its systemic and local administration induces scratching behavior in rodents, dogs and monkeys. Recent clinical trials have revealed that administration of an anti‐IL‐31 receptor antibody significantly alleviates pruritus in patients with AD. In this review, we summarize recent topics related to IL‐31 and its receptor with special references to atopic itch.
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IL-31 is a pruritogenic cytokine produced by TH2 cells infiltrating atopic dermatitis skin, and its levels correlate with disease severity.
“IL-31 is a prominent pruritogenic cytokine produced by infiltrating TH2 cells in AD and correlates with disease severity97,184,185.”
From Atopic dermatitis: an expanding therapeutic pipeline for a complex disease (2022) · cites this paper as [184]
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Williams, H. C., Leung, D. Y. M., Thestrup‐Pedersen, K., & David, T. J. (2000) · Cited by 4,597 · see citing works
Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis
Simpson, E. L., Bieber, T., Guttman-Yassky, E., Beck, L. A., Blauvelt, A., Cork, M. J., Silverberg, J. I., Deleuran, M., Kataoka, Y., Lacour, J.-P., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1610020 · Cited by 2,110 · see citing works
Weidinger, S., & Novak, N. (2016) · The Lancet · doi:10.1016/s0140-6736(15)00149-x · Cited by 1,908 · see citing works
Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice
Dillon, S. R., Sprecher, C. A., Hammond, A. J., Bilsborough, J., Rosenfeld-Franklin, M., Presnell, S., Haugen, H. S., Maurer, M. F., Harder, B., Johnston, J. V., et al. (2004) · Nature Immunology · doi:10.1038/ni1084 · Cited by 1,014 · see citing works
IL-31: A new link between T cells and pruritus in atopic skin inflammation
Sonkoly, E., Müller, A., Lauerma, A., Pivarcsi, A., Soto, H., Kemény, L. V., Alenius, H. T., Dieu‐Nosjean, M., Meller, S., Rieker, J., et al. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.10.033 · Cited by 1,000 · see citing works
Cevikbas, F., Wang, X., Akiyama, T., Kempkes, C., Savinko, T., Antal, A. S., Kukova, G., Buhl, T., Ikoma, A., Buddenkotte, J., et al. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.10.048 · Cited by 806 · see citing works
A subpopulation of nociceptors specifically linked to itch
Han, L., Ma, C., Liu, Q., Weng, H.-J., Cui, Y., Tang, Z., Kim, Y., Nie, H., Qu, L., Patel, K., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3289 · Cited by 614 · see citing works
Anti–Interleukin-31 Receptor A Antibody for Atopic Dermatitis
Ruzicka, T., Hanifin, J. M., Furue, M., Pulka, G., Mlynarczyk, I., Wollenberg, A., Galus, R., Etoh, T., Mihara, R., Yoshida, H., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1606490 · Cited by 592 · see citing works
Self-citationTopical tofacitinib for atopic dermatitis: a phase II a randomized trial
Bissonnette, R., Papp, K. A., Poulin, Y. P., Gooderham, M., Raman, M., Mallbris, L., Wang, C., Purohit, V. S., Mamolo, C. M., Papacharalambous, J., et al. (2016) · British Journal of Dermatology · doi:10.1111/bjd.14871 · Cited by 420 · see citing works
Bilsborough, J., Leung, D. Y. M., Maurer, M. F., Howell, M. D., Boguniewcz, M., Yao, L. Y., Storey, H., LeCiel, C., Harder, B., & Gross, J. A. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.10.046 · Cited by 368 · see citing works
Atopic dermatitis: immune deviation, barrier dysfunction, IgE autoreactivity and new therapies
Furue, M., Chiba, T., Tsuji, G., Ulzii, D., Kido‐Nakahara, M., Nakahara, T., & Kadono, T. (2017) · Allergology International · doi:10.1016/j.alit.2016.12.002 · Cited by 324 · see citing works
Self-citationCorrelation of IL-31 serum levels with severity of atopic dermatitis
Raap, U., Wichmann, K., Bruder, M., Ständer, S., Wedi, B., Kapp, A., & Werfel, T. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.05.047 · Cited by 299 · cited 8× · see citing works
“In addition, the serum levels of IL-31 are significantly increased in AD compared to healthy controls and are correlated with the severity of pediatric and adult AD.(69,70) The levels of IL-”
BackgroundInfluentialGenomic views of STAT function in CD4+ T helper cell differentiation
O'Shea, J. J., Lahesmaa, R., Vahedi, G., Laurence, A., & Kanno, Y. (2011) · Nature Reviews Immunology · doi:10.1038/nri2958 · Cited by 295 · see citing works
Structures and biological functions of IL-31 and IL-31 receptors
Zhang, Q., Putheti, P., Zhou, Q., Liu, Q., & Gao, W. (2008) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2008.08.003 · Cited by 286 · see citing works
The pruritus- and TH2-associated cytokine IL-31 promotes growth of sensory nerves
Feld, M., García, R., Buddenkotte, J., Katayama, S., Lewis, K. E., Muirhead, G., Hevezi, P. A., Plesser, K., Schrumpf, H., Krjutškov, K., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.02.020 · Cited by 285 · see citing works
Niyonsaba, F., Ushio, H., Hara, M., Yokoi, H., Tominaga, M., Takamori, K., Kajiwara, N., Saito, H., Nagaoka, I., Ogawa, H., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0900712 · Cited by 281 · see citing works
Gonzales, A. J., Bowman, J. W., Fici, G. J., Zhang, M., Mann, D. W., & Mitton‐Fry, M. J. (2014) · Journal of Veterinary Pharmacology and Therapeutics · doi:10.1111/jvp.12101 · Cited by 265 · see citing works
Oncostatin M and interleukin-31: Cytokines, receptors, signal transduction and physiology
Hermanns, H. M. (2015) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2015.07.006 · Cited by 263 · see citing works
Filaggrin Mutations Strongly Predispose to Early-Onset and Extrinsic Atopic Dermatitis
Weidinger, S., Rodríguez, E., Stahl, C., Wagenpfeil, S., Klopp, N., Illig, T., & Novak, N. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700630 · Cited by 254 · see citing works
STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch
Shiratori‐Hayashi, M., Koga, K., Tozaki‐Saitoh, H., Kohro, Y., Toyonaga, H., Chiharu, Y., Hasegawa, A., Nakahara, T., Hachisuka, J., Akira, S., et al. (2015) · Nature Medicine · doi:10.1038/nm.3912 · Cited by 219 · see citing works
Self-citationDOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation
Jabara, H. H., McDonald, D. R., Janssen, E., Massaad, M. J., Ramesh, N., Borzutzky, A., Rauter, I., Benson, H., Schneider, L. C., Baxi, S. N., et al. (2012) · Nature Immunology · doi:10.1038/ni.2305 · Cited by 216 · see citing works
Grimstad, Ø., Sawanobori, Y., Vestergaard, C., et al. (2008) · Experimental Dermatology · doi:10.1111/j.1600-0625.2008.00766.x · Cited by 203 · see citing works
The extended clinical phenotype of 64 patients with dedicator of cytokinesis 8 deficiency
Engelhardt, K. R., Gertz, E. M., Keleş, S., Schäffer, A. A., Sigmund, E. C., Glocker, C., Saghafi, S., Pourpak, Z., Ceja, R., Sassi, A., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.12.1945 · Cited by 197 · see citing works
Cutaneous nerves in atopic dermatitis
Urashima, R., & Mihara, M. (1998) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s004280050179 · Cited by 193 · see citing works
Nemoto, O., FURUE, M., Nakagawa, H., Shiramoto, M., Hanada, R., Matsuki, S., Imayama, S., Kato, M., Hasebe, I., Taira, K., et al. (2015) · British Journal of Dermatology · doi:10.1111/bjd.14207 · Cited by 191 · see citing works
Self-citationChamlin, S. L., Mattson, C. L., Frieden, I. J., Williams, M. L. K., Mancini, A. J., Cella, D. F., & Chren, M. (2005) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.159.8.745 · Cited by 186 · see citing works
Targeted disruption of oncostatin M receptor results in altered hematopoiesis
Tanaka, M., Hirabayashi, Y., Sekiguchi, T., Inoue, T., Katsuki, M., & Miyajima, A. (2003) · Blood · doi:10.1182/blood-2003-02-0367 · Cited by 178 · see citing works
Human IL-31 is induced by IL-4 and promotes TH2-driven inflammation
Stott, B., Lavender, P., Lehmann, S., Pennino, D., Durham, S., & Schmidt‐Weber, C. B. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.03.050 · Cited by 173 · see citing works
Clinical Practice Guidelines for the Management of Atopic Dermatitis 2016
Saeki, H., Nakahara, T., Tanaka, A., Kabashima, K., Sugaya, M., Murota, H., Ebihara, T., Kataoka, Y., Aihara, M., Etoh, T., et al. (2016) · The Journal of Dermatology · doi:10.1111/1346-8138.13392 · Cited by 171 · see citing works
Self-citationA Pilot Study of an Oral Phosphodiesterase Inhibitor (Apremilast) for Atopic Dermatitis in Adults
Samrao, A., Berry, T. M., Goreshi, R., & Simpson, E. L. (2012) · Archives of Dermatology · doi:10.1001/archdermatol.2012.812 · Cited by 166 · see citing works
Ezzat, M., Hasan, Z., & Shaheen, K. Y. A. (2010) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2010.03794.x · Cited by 142 · see citing works
Interleukin‐31: its role in canine pruritus and naturally occurring canine atopic dermatitis
Gonzales, A. J., Humphrey, W. R., Messamore, J. E., Fleck, T. J., Fici, G. J., Shelly, J. A., Teel, J. F., Bammert, G. F., Dunham, S. A., Fuller, T. E., et al. (2013) · Veterinary Dermatology · doi:10.1111/j.1365-3164.2012.01098.x · Cited by 139 · see citing works
Murata, Y., Song, M., Kikuchi, H., Hisamichi, K., Xu, X. L., Greenspan, A. J., Kato, M., Chiou, C., Kato, T., Guzzo, C. A., et al. (2014) · The Journal of Dermatology · doi:10.1111/1346-8138.12726 · Cited by 133 · see citing works
Self-citationHawro, T., Saluja, R., Weller, K., Altrichter, S., Metz, M., & Maurer, M. (2013) · Allergy · doi:10.1111/all.12316 · Cited by 125 · see citing works
Increased frequencies of IL‐31‐producing T cells are found in chronic atopic dermatitis skin
Szegedi, K., Kremer, A. E., Kežić, S., Teunissen, M. B. M., Bos, J. D., Luiten, R. M., Res, P. C., & Middelkamp-Hup, M. A. (2012) · Experimental Dermatology · doi:10.1111/j.1600-0625.2012.01487.x · Cited by 121 · see citing works
Human basophils are a source of ‐ and are differentially activated by ‐ IL‐31
Raap, U., Gehring, M., Kleiner, S., Rüdrich, U., Eiz‐Vesper, B., Haas, H., Kapp, A., & Gibbs, B. F. (2016) · Clinical & Experimental Allergy · doi:10.1111/cea.12875 · Cited by 120 · see citing works
[CLINICAL PRACTICE GUIDELINES FOR THE MANAGEMENT OF ATOPIC DERMATITIS 2018].
Ebihara, T. (2022) · PubMed · doi:10.15036/arerugi.70.1186 · Cited by 119 · see citing works
Cutaneous T-cell Lymphoma and Pruritus: The Expression of IL-31 and its Receptors in the Skin
Nattkemper, L. A., Martínez‐Escala, M. E., Gelman, A. E., Singer, E., Rook, A. H., Guitart, J., & Yosipovitch, G. (2016) · Acta Dermato Venereologica · doi:10.2340/00015555-2417 · Cited by 113 · see citing works
Distribution of IL-31 and its receptor expressing cells in skin of atopic dermatitis
Kato, A., Fujii, E., Watanabe, T., Takashima, Y., Matsushita, H., Furuhashi, T., & Morita, A. (2014) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2014.02.009 · Cited by 110 · see citing works
Functional effects of interleukin 31 in human primary keratinocytes
Kasraie, S., Niebuhr, M., Baumert, K., & Werfel, T. (2011) · Allergy · doi:10.1111/j.1398-9995.2011.02545.x · Cited by 99 · see citing works
Michels, G. Μ., Ramsey, D. S., Walsh, K. A., Martinon, O. M., Mahabir, S. P., Hoevers, J. D., Walters, R. R., & Dunham, S. A. (2016) · Veterinary Dermatology · doi:10.1111/vde.12376 · Cited by 95 · see citing works
Diveu, C., Lak‐Hal, A. L., Froger, J., et al. (2005) · PubMed · Cited by 91 · see citing works
IL-31–IL-31R interactions negatively regulate type 2 inflammation in the lung
Perrigoue, J., Li, J., Zaph, C., Goldschmidt, M. H., Scott, P., de Sauvage, F. J., Pearce, E. J., Ghilardi, N., & Artis, D. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061791 · Cited by 89 · see citing works
Dai, X., Okazaki, H., Hanakawa, Y., Murakami, M., Tohyama, M., Shirakata, Y., & Sayama, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067666 · Cited by 88 · see citing works
Characterization of the Signaling Capacities of the Novel gp130-like Cytokine Receptor*
Dreuw, A., Radtke, S., Pflanz, S., Lippok, B., Heinrich, P., & Hermanns, H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401122200 · Cited by 87 · see citing works
Kunsleben, N., Rüdrich, U., Gehring, M., Novak, N., Kapp, A., & Raap, U. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.106 · Cited by 85 · see citing works
Yamamura, K., Uruno, T., Shiraishi, A., Tanaka, Y., Ushijima, M., Nakahara, T., Watanabe, M., Kido‐Nakahara, M., Tsuge, I., Furue, M., et al. (2017) · Nature Communications · doi:10.1038/ncomms13946 · Cited by 82 · see citing works
Self-citationTakei, K., Mitoma, C., Hashimoto‐Hachiya, A., Uchi, H., Takahara, M., Tsuji, G., Kido‐Nakahara, M., Nakahara, T., & Furue, M. (2015) · The Journal of Dermatology · doi:10.1111/1346-8138.12717 · Cited by 81 · see citing works
Self-citationSingh, B. B., Jegga, A. G., Shanmukhappa, K. S., Edukulla, R., Khurana, G. H., Medvedovic, M., Dillon, S. R., & Madala, S. K. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161877 · Cited by 81 · see citing works
Kido‐Nakahara, M., Furue, M., Ulzii, D., & Nakahara, T. (2016) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2016.08.007 · Cited by 81 · see citing works
Self-citationRelieving the Pruritus of Atopic Dermatitis: A Meta-analysis
Sher, L. G., Chang, J., Patel, I., Balkrishnan, R., & Fleischer, A. B. (2012) · Acta Dermato Venereologica · doi:10.2340/00015555-1360 · Cited by 80 · see citing works
Control of the Physical and Antimicrobial Skin Barrier by an IL-31–IL-1 Signaling Network
Hänel, K. H., Pfaff, C. M., Cornelissen, C. G., Amann, P. M., Marquardt, Y., Czaja, K., Kim, A. L., Lüscher, B., & Baron, J. M. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1402943 · Cited by 76 · see citing works
Kasutani, K., Fujii, E., Ohyama, S., Adachi, H., Hasegawa, M., Kitamura, H., & Yamashita, N. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12823 · Cited by 73 · see citing works
Human Th2 but Not Th9 Cells Release IL-31 in a STAT6/NF-κB–Dependent Way
Maier, E., Werner, D., Duschl, A., Bohle, B., & Horejs‐Hoeck, J. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1301836 · Cited by 67 · see citing works
Horejs‐Hoeck, J., Schwarz, H., Lamprecht, S., Maier, E., Hainzl, S., Schmittner, M., Posselt, G., Stoecklinger, A., Hawranek, T., & Duschl, A. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1101044 · Cited by 66 · see citing works
Gonzales, A. J., Fleck, T. J., Humphrey, W. R., Galvan, B. A., Aleo, M. M., Mahabir, S. P., Tena, J., Greenwood, K. G., & McCall, R. B. (2015) · Veterinary Dermatology · doi:10.1111/vde.12280 · Cited by 66 · see citing works
Oyama, S., Kitamura, H., Kuramochi, T., Higuchi, Y., Matsushita, H., Suzuki, T., Goto, M., Adachi, H., Kasutani, K., Sakamoto, A., et al. (2016) · Experimental Dermatology · doi:10.1111/exd.13236 · Cited by 57 · see citing works
Park, J., Jekarl, D. W., Kim, Y., Kim, J., Kim, M., & Park, Y. M. (2015) · The Journal of Dermatology · doi:10.1111/1346-8138.12935 · Cited by 50 · see citing works
Staphylococcal α-Toxin Induces a Higher T Cell Proliferation and Interleukin-31 in Atopic Dermatitis
Niebuhr, M., Mamerow, D., Heratizadeh, A., Satzger, I., & Werfel, T. (2011) · International Archives of Allergy and Immunology · doi:10.1159/000323905 · Cited by 50 · see citing works
IL-31 Receptor (IL-31RA) Knockout Mice Exhibit Elevated Responsiveness to Oncostatin M
Bilsborough, J., Mudri, S., Chadwick, E. M., Harder, B., & Dillon, S. R. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902769 · Cited by 48 · see citing works
Murota, H., Takeuchi, S., Sugaya, M., Tanioka, M., Onozuka, D., Hagihara, A., Saeki, H., Imafuku, S., Abe, M., Shintani, Y., et al. (2015) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2015.05.010 · Cited by 48 · see citing works
Self-citationTh2 Cytokines Augment IL-31/IL-31RA Interactions via STAT6-dependent IL-31RA Expression
Edukulla, R., Singh, B. B., Jegga, A. G., Sontake, V., Dillon, S. R., & Madala, S. K. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.622126 · Cited by 47 · see citing works
Michels, G. Μ., Walsh, K. A., Kryda, K., et al. (2016) · Veterinary Dermatology · doi:10.1111/vde.12364 · Cited by 47 · see citing works
Nemoto, O., Hayashi, N., Kitahara, Y., Furue, M., Hojo, S., Nomoto, M., Shima, S., & The Japanese E6005 Study Investigators (2016) · The Journal of Dermatology · doi:10.1111/1346-8138.13231 · Cited by 45 · see citing works
Self-citationAnti‐inflammatory therapies in atopic dermatitis
Heratizadeh, A., & Werfel, T. (2016) · Allergy · doi:10.1111/all.13065 · Cited by 45 · see citing works
McCandless, E. E., Rugg, C. A., Fici, G. J., Messamore, J. E., Aleo, M. M., & Gonzales, A. J. (2013) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2013.10.017 · Cited by 45 · see citing works
Lewis, K. E., Holdren, M. S., Maurer, M. F., Underwood, S., Meengs, B., Julien, S. H., Byrnes-Blake, K. A., Freeman, J. A., Bukowski, T., Wolf, A. C., et al. (2016) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.13794 · Cited by 43 · see citing works
Kasraie, S., Niebuhr, M., & Werfel, T. (2013) · Allergy · doi:10.1111/all.12152 · Cited by 42 · see citing works
Koizume, S., Ito, S., Miyagi, E., Hirahara, F., Nakamura, Y., Sakuma, Y., Osaka, H., Takano, Y., Ruf, W., & Miyagi, Y. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks201 · Cited by 42 · see citing works
Xie, L., & Collins, J. F. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.489500 · Cited by 39 · see citing works
Maier, E., Mittermeir, M., Ess, S., Neuper, T., Schmiedlechner, A., Duschl, A., & Horejs‐Hoeck, J. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.661306 · Cited by 33 · see citing works
New therapies for controlling atopic itch
Furue, M., & Kadono, T. (2015) · The Journal of Dermatology · doi:10.1111/1346-8138.13060 · Cited by 32 · see citing works
Self-citationEffects of Interleukin-31 on MUC5AC Gene Expression in Nasal Allergic Inflammation
Shah, S. A., Ishinaga, H., Hou, B., et al. (2013) · Pharmacology · doi:10.1159/000346609 · Cited by 29 · see citing works
Collared mice: A model to assess the effects of scratching
Takeuchi, S., Yasukawa, F., Furue, M., & Katz, S. I. (2009) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2009.09.008 · Cited by 25 · see citing works
Self-citationCalkins, C. M., Barsness, K. A., Bensard, D. D., et al. (2002) · Journal of Surgical Research · doi:10.1006/jsre.2002.6422 · Cited by 23 · see citing works
Esaki, H., Takeuchi, S., Furusyo, N., Yamamura, K., Hayashida, S., Tsuji, G., Takemura, M., Hayashi, J., & Furue, M. (2016) · The Journal of Dermatology · doi:10.1111/1346-8138.13360 · Cited by 23 · see citing works
Self-citationNeurophysiology and Itch Pathways
Schmelz, M. (2015) · Handbook of experimental pharmacology · doi:10.1007/978-3-662-44605-8_3 · Cited by 19 · see citing works
Regulation of Th2 responses by different cell types expressing the interleukin-31 receptor
Saitô, S., Aoki, A., Arai, I., Takaishi, S., Ito, H., Akiyama, N., & Kiyonari, H. (2017) · Allergy Asthma and Clinical Immunology · doi:10.1186/s13223-017-0194-9 · Cited by 17 · see citing works
Parker, J. C., Thavagnanam, S., Skibiński, G., McBrien, M. E., Heaney, L. G., & Shields, M. D. (2012) · Results in Immunology · doi:10.1016/j.rinim.2012.05.001 · Cited by 7 · see citing works
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- Authors
- Furue, M., Yamamura, K., Kido‐Nakahara, M., Nakahara, T., & Fukui, Y.
- Affiliations
- Kyushu University (JP)
- Corresponding author
- Furue, M.
- Venue
- Allergy
- Publisher
- Wiley
- Published
- 2017-07-20
- Volume
- 73
- Issue
- 1
- Pages
- 29-36
- ISSN
- 0105-4538 (ISSN-L)
- 1398-9995
- OpenAlex
- W2732263256
- Cited by
- 240
- References
- 79
- Citations by year
- 2026: 9 · 2025: 20 · 2024: 29 · 2023: 26 · 2022: 27 · 2021: 39 · 2020: 28 · 2019: 32 · 2018: 26 · 2017: 4
- FWCI
- 4.41
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Allergy (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- IL-31, atopic dermatitis, pruritus, Th2 cells, skin barrier dysfunction
- MeSH terms
- Endothelial PAS Domain-Containing Protein 1, Dermatitis, Atopic, Gene Expression Regulation, Humans, Interleukins, Pruritus, Structure-Activity Relationship, Biomarkers, Cytokines, Receptors, Interleukin, Inflammation Mediators, Disease Management, Basic Helix-Loop-Helix Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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