Histamine-secreting microbes are increased in the gut of adult asthma patients
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The human fecal microbiota is enriched with bacterial species that express the histidine decarboxylase gene, suggesting a capacity to synthesize histamine within the host gut.
“Indeed, the human fecal microbiota is enriched with bacterial species that express the histidine decarboxylase gene, suggesting a capacity to synthesize histamine within the host gut (Barcik et al., 2016).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Barcik et al., 2016
The 'To the Editor' section reports higher levels of the bacterial HDC gene in fecal samples from adults with asthma than in healthy controls, and identifies fecal isolates that secreted histamine ex vivo. The claim omits the asthma-specific comparison and says the species express the gene, whereas the study measured gene presence rather than expression. The isolates support a capacity to produce histamine, but the reported secretion was measured outside the host gut. (LLM, conf=0.86)
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Research works printed but not linked: 18
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Gao, C., Ganesh, B. P., Shi, Z., Shah, R. R., Fultz, R., Major, A., Venable, S., Lugo, M., Hoch, K., Chen, X., et al. (2017) · The American Journal of Pathology · doi:10.1016/j.ajpath.2017.06.011 · Cited by 122 · see citing works
Bacterial Secretion of Histamine Within the Gut Influences Immune Responses Within the Lung
Barcik, W., Pugin, B., Brescó, M. S., Westermann, P., Rinaldi, A., Groeger, D., Van Elst, D., Sokolowska, M., Krawczyk, K., Frei, R., et al. (2019) · Allergy · doi:10.1111/all.13709 · Cited by 98 · see citing works
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- Authors
- Barcik, W., Pugin, B., Westermann, P., Perez, N. R., Ferstl, R., Wawrzyniak, M., Smolinska, S., Jutel, M., Hessel, E. M., Michalovich, D., Akdis, C. A., Frei, R., & O'Mahony, L.
- Affiliations
- University of Zurich (CH)
- Wroclaw Medical University (PL)
- GlaxoSmithKline (United Kingdom) (GB)
- ORCID
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 138
- Issue
- 5
- Pages
- 1491-1494.e7
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W2505274875
- Cited by
- 142
- References
- 0
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 16 · 2023: 14 · 2022: 18 · 2021: 19 · 2020: 13 · 2019: 20 · 2018: 15 · 2017: 11 · 2016: 1
- FWCI
- 8.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Allergy and Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- European Commission (260895, 261357)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Keywords
- histamine, gut microbiota, adult asthma, dysbiosis, microbiome-host interactions, biogenic amines, immune regulation, microbial metabolites
- MeSH terms
- Gastrointestinal Microbiome, Adult, Asthma, Feces, Female, Histamine, Humans, Male, Case-Control Studies, Host-Pathogen Interactions
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