The association of a probiotic with a prebiotic (Flortec, Bracco) to improve the quality/quantity of spermatozoa in infertile patients with idiopathic oligoasthenoteratospermia: a pilot study
Abstract
Summary: The hypothesis that the assumption of a probiotic associated with a prebiotic (Flortec, Bracco; one sachet contains: Lactobacillus paracasei B21060 5 × 10 9 cells + arabinogalctan 1243 mg + oligo‐fructosaccharides 700 mg + l ‐glutamine 500 mg) could improve the quality and quantity of spermatozoa in idiopathic oligoasthenoteratospermia ( iAOT ) patients to a larger extent than a control substance (starch) was tested. Forty‐one patients with no chromosomal aberrations were randomized into two groups: 20 received Flortec, one sachet per day for 6 months, whereas 21 received the control substance. The following data were collected: clinical history, scrotal Doppler scans, Y microdeletion, karyotype and cystic fibrosis screens, follicle‐stimulating hormone ( FSH ), luteinizing hormone ( LH ), estradiol (E2), testosterone (T), and prolactin ( PRL ) levels, and two semen analyses. Both the Flortec and the starch groups underwent two semen analyses and one FSH , LH , T, E2, and PRL measurement in the blood, at the beginning of the study, and after 6 months. The comparisons were carried out using a non‐parametric (Wilcoxon signed rank) test. The side effects were assessed and compared using the chi‐squared test. Group 1 (Flortec) had their sperm count improved: volume of the ejaculate (median from 2.4 to 3.1 mL; p < 0.01), sperm concentration (median: from 15.2 × 10 6 /mL to 28.3 × 10 6 /39 mL; p < 0.01), progressive motility (median: from 16.2 to 42.0%; p < 0.01), and the percentage of typical forms (median: from 7 to 16.3%; p < 0.01); in addition, their FSH , LH , and T levels improved ( p < 0.01), while those of E2 and PRL did not. Group 2 (control substance) had no modification in 42 of the parameters studied. There were no side effects in either group. These data showed that Flortec constitutes a safe therapy for improving the volume of the ejaculate and the quality/quantity of spermatozoa in iOAT patients.
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In another pilot study, a probiotic and prebiotic supplement over 6 months in infertile male patients improved gonadal pathway function including increased FSH, LH, and testosterone compared to control.
“However, another pilot study supplementing a probiotic and prebiotic (L. paracasei B21060 5 × 109 cells + arabinogalactan 1243 mg + fructooligosaccharides 700 mg + L-glutamine 500 mg) over 6 months in infertile male patients improved gonadal pathway function including increased follicle stimulating hormone, luteinizing hormone, and testosterone levels compared to a control group [256].”
From International Society of Sports Nutrition Position Stand: Probiotics (2019) · cites this paper as [256]
Cites
World Health Organization reference values for human semen characteristics*‡
Cooper, T. G., Noonan, E., von Eckardstein, S., Auger, J., Baker, H. W. G., Behre, H. M., Haugen, T. B., Kruger, T., Wang, C., Mbizvo, M. T., et al. (2010) · Human Reproduction Update · doi:10.1093/humupd/dmp048 · Cited by 2,827 · see citing works
Statistical Methods in Medical Research
Armitage, P., Berry, G., & Matthews, J. N. S. (2002) · Wiley eBooks · doi:10.1002/9780470773666 · Cited by 1,638 · see citing works
Turner, L., Shamseer, L., Altman, D. G., Schulz, K. F., & Moher, D. (2012) · Systematic Reviews · doi:10.1186/2046-4053-1-60 · Cited by 628 · see citing works
Antioxidants for male subfertility
Showell, M. G., Mackenzie-Proctor, R., Brown, J., Yazdani, A., Stankiewicz, M. T., & Hart, R. J. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007411.pub3 · Cited by 285 · see citing works
Microbiota of the seminal fluid from healthy and infertile men
Hou, D., Zhou, X., Zhong, X., Settles, M. L., Herring, J., Wang, L., Abdo, Z., Forney, L. J., & Xu, C. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.07.1991 · Cited by 266 · see citing works
Male idiopathic oligoasthenoteratozoospermia
Cavallini, G. (2006) · Asian Journal of Andrology · doi:10.1111/j.1745-7262.2006.00123.x · Cited by 174 · see citing works
Self-citationFood, nutrients and nutraceuticals affecting the course of inflammatory bowel disease
Uranga, J. A., López‐Miranda, V., Lombó, F., & Abalo, R. (2016) · Pharmacological Reports · doi:10.1016/j.pharep.2016.05.002 · Cited by 131 · see citing works
Testing a Primary and a Secondary Endpoint in a Group Sequential Design
Tamhane, A. C., Mehta, C. R., & Liu, L. (2010) · Biometrics · doi:10.1111/j.1541-0420.2010.01402.x · Cited by 68 · see citing works
Kisspeptin Regulation of Neuronal Activity throughout the Central Nervous System
Liu, X., & Herbison, A. E. (2016) · Endocrinology and Metabolism · doi:10.3803/enm.2016.31.2.193 · Cited by 59 · see citing works
Cavallini, G., Biagiotti, G., & Bolzon, E. (2013) · Asian Journal of Andrology · doi:10.1038/aja.2013.99 · Cited by 57 · see citing works
Self-citationOptimal management of extreme oligozoospermia by an appropriate cryopreservation programme
Koscinski, I., Wittemer, C., Lefebvre‐Khalil, V., marcelli, F., Défossez, A., & Rigot, J.-M. (2007) · Human Reproduction · doi:10.1093/humrep/dem190 · Cited by 35 · see citing works
Reference value of semen quality in Chinese young men
Jun-qing, W., Qiuying, Y., Jianguo, T., Wei, Y., Bo, L.-W., Li, Y.-X., Yumei, Z., Kangshou, Y., Lu, W., Chen, L., et al. (2002) · Contraception · doi:10.1016/s0010-7824(02)00281-0 · Cited by 33 · see citing works
Efficacy of oral Bifidobacterium bifidum ATCC 29521 on microflora and antioxidant in mice
Wang, B., Xu, H., Xu, F., Zeng, Z., & Wei, H. (2015) · Canadian Journal of Microbiology · doi:10.1139/cjm-2015-0685 · Cited by 33 · see citing works
Spermatid count as a predictor of response to FSH therapy
Garolla, A., Selice, R., Engl, B., Bertoldo, A., Menegazzo, M., Finos, L., Lenzi, A., & Foresta, C. (2014) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2014.02.014 · Cited by 27 · see citing works
Wdowiak, A., Bakalczuk, S., & Bakalczuk, G. (2015) · Andrology · doi:10.1111/andr.12061 · Cited by 24 · see citing works
Cavallini, G., Crippa, A., Magli, M. C., Cavallini, N., Ferraretti, A. P., & Gianaroli, L. (2008) · Biology of Reproduction · doi:10.1095/biolreprod.107.067330 · Cited by 17 · see citing works
Self-citation
Flagged first, then by citations
1 of the 17 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
International Society of Sports Nutrition Position Stand: Probiotics
Jäger, R., Mohr, A. E., Carpenter, K. C., Kerksick, C. M., Purpura, M., Moussa, A., Townsend, J. R., Lamprecht, M., West, N. P., Black, K., et al. (2019) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-019-0329-0 · Cited by 277 · see citing works
The seminal microbiome in health and disease
Altmäe, S., Franasiak, J. M., & Mändar, R. (2019) · Nature Reviews Urology · doi:10.1038/s41585-019-0250-y · Cited by 192 · see citing works
Molina, N. M., Sola‐Leyva, A., Sáez‐Lara, M. J., Plaza‐Díaz, J., Tubić-Pavlović, A., Romero, B., Clavero, A., Mozas‐Moreno, J., Fontes, J., & Altmäe, S. (2020) · Biomolecules · doi:10.3390/biom10040593 · Cited by 189 · see citing works
Salas‐Huetos, A., Rosique-Esteban, N., Becerra‐Tomás, N., Vizmanos-Lamotte, B., Bulló, M., & Salas‐Salvadó, J. (2018) · Advances in Nutrition · doi:10.1093/advances/nmy057 · Cited by 154 · see citing works
Microbiota and Human Reproduction: The Case of Female Infertility
Tomaiuolo, R., Veneruso, I., Cariati, F., & D’Argenio, V. (2020) · Microarrays · doi:10.3390/ht9020012 · Cited by 111 · see citing works
Dardmeh, F., Alipour, H., Gazerani, P., van der Horst, G., Brandsborg, E., & Nielsen, H. I. (2017) · PLoS ONE · doi:10.1371/journal.pone.0185964 · Cited by 104 · see citing works
Endotoxin-initiated inflammation reduces testosterone production in men of reproductive age
Tremellen, K., McPhee, N., Pearce, K., Benson, S., Schedlowski, M., & Engler, H. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00279.2017 · Cited by 98 · see citing works
Probiotics, Non-Dairy Prebiotics and Postbiotics in Nutrition
Tomasik, P., & Tomasik, P. (2020) · Applied Sciences · doi:10.3390/app10041470 · Cited by 97 · see citing works
Shaping Microbiota During the First 1000 Days of Life
Selma‐Royo, M., Tarrazó, M., García‐Mantrana, I., Gómez-Gallego, C., Salminen, S., & Collado, M. C. (2019) · Advances in experimental medicine and biology · doi:10.1007/5584_2018_312 · Cited by 92 · see citing works
Zhang, Y., Hou, B., Liu, T., Wu, Y., & Wang, Z. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.115248 · Cited by 86 · see citing works
Current and emerging medical therapeutic agents for idiopathic male infertility
Duca, Y., Calogero, A. E., Cannarella, R., Condorelli, R. A., & Vignera, S. L. (2018) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2018.1543405 · Cited by 77 · see citing works
Helli, B., Kavianpour, M., Ghaedi, E., Dadfar, M., & Haghighian, H. K. (2020) · Human Fertility · doi:10.1080/14647273.2020.1824080 · Cited by 71 · see citing works
RetractedGut microbiota is involved in male reproductive function: a review
Lv, S., Huang, J., Luo, Y., Wen, Y., Chen, B., Qiu, H., Chen, H., Yue, T., He, L., Feng, B., et al. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1371667 · Cited by 65 · see citing works
Microbiota and Human Reproduction: The Case of Male Infertility
Tomaiuolo, R., Veneruso, I., Cariati, F., & D’Argenio, V. (2020) · Microarrays · doi:10.3390/ht9020010 · Cited by 64 · see citing works
Firmicutes in Gut Microbiota Correlate with Blood Testosterone Levels in Elderly Men
Matsushita, M., Fujita, K., Motooka, D., Hatano, K., Hata, J., Nishimoto, M., Banno, E., Takezawa, K., Fukuhara, S., Kiuchi, H., et al. (2022) · The World Journal of Men s Health · doi:10.5534/wjmh.210190 · Cited by 63 · see citing works
Pearce, K. L., Hill, A., & Tremellen, K. P. (2019) · Basic and Clinical Andrology · doi:10.1186/s12610-019-0087-5 · Cited by 61 · see citing works
van Dorst, J. M., Tam, R. Y., & Ooi, C. Y. (2022) · Nutrients · doi:10.3390/nu14030480 · Cited by 60 · see citing works
The Use of Probiotics for Management and Improvement of Reproductive Eubiosis and Function
Hashem, N. M., & Gonzalez‐Bulnes, A. (2022) · Nutrients · doi:10.3390/nu14040902 · Cited by 57 · see citing works
Omar, M. I., Pal, R. P., Kelly, B. D., Bruins, H. M., Yuan, Y., Thorsten Diemer, A., Krausz, C. G., Tournaye, H. J., Kopa, Z., Jungwirth, A., et al. (2019) · European Urology · doi:10.1016/j.eururo.2018.12.022 · Cited by 56 · see citing works
Basavaprabhu, H. N., Shivanna, S. K., & Prabha, R. (2020) · Microbial Pathogenesis · doi:10.1016/j.micpath.2020.104029 · Cited by 57 · see citing works
Kaltsas, A., Zachariou, A., Markou, E., Dimitriadis, F., Sofikitis, N., & Pournaras, S. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13101491 · Cited by 43 · see citing works
The role of probiotics in women's health: An update narrative review
Wu, L., Yang, T., Ou, Y., & Lin, H. (2024) · Taiwanese Journal of Obstetrics and Gynecology · doi:10.1016/j.tjog.2023.09.018 · Cited by 47 · see citing works
The microbiome of the infertile male
Lundy, S. D., Vij, S. C., Rezk, A. H., Cohen, J. A., Bajic, P., & Ramasamy, R. (2020) · Current Opinion in Urology · doi:10.1097/mou.0000000000000742 · Cited by 40 · see citing works
The Microbiome, an Important Factor That Is Easily Overlooked in Male Infertility
Wang, H., Xu, A., Gong, L., Chen, Z., Zhang, B., & Li, X. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.831272 · Cited by 40 · see citing works
Probiotic therapy in couples with infertility: A systematic review
Corbett, G., Crosby, D., & McAuliffe, F. (2021) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2020.10.054 · Cited by 39 · see citing works
Ommati, M. M., Li, H., Jamshidzadeh, A., Khoshghadam, F., Retana‐Márquez, S., Lu, Y., Farshad, O., Ahmadi, M. H. N., Gholami, A., & Heidari, R. (2022) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-021-02177-0 · Cited by 37 · see citing works
RetractedLin, Y., Wang, K., Che, L., Fang, Z., Xu, S., Feng, B., Zhuo, Y., Li, J., Wu, C., Zhang, J., et al. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.863315 · Cited by 37 · see citing works
Male infertility and the human microbiome
Magill, R. G., & MacDonald, S. M. (2023) · Frontiers in Reproductive Health · doi:10.3389/frph.2023.1166201 · Cited by 36 · see citing works
Male Tract Microbiota and Male Infertility
Grande, G., Graziani, A., Toni, L. D., Garolla, A., & Ferlin, A. (2024) · Cells · doi:10.3390/cells13151275 · Cited by 36 · see citing works
Chen, W., Zou, H., Xu, H., Cao, R., Zhang, H., Zhang, Y., & Zhao, J. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1478082 · Cited by 39 · see citing works
Akram, M., Ali, S. A., Behare, P. V., & Kaul, G. (2021) · Food & Function · doi:10.1039/d1fo02501e · Cited by 35 · see citing works
Leukocytospermia and/or Bacteriospermia: Impact on Male Infertility
Henkel, R. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13102841 · Cited by 34 · see citing works
Probiotics and the envisaged role in treating human infertility
Younis, N., & Mahasneh, A. M. (2020) · Middle East Fertility Society Journal · doi:10.1186/s43043-020-00039-y · Cited by 34 · see citing works
Abbasi, B., Abbasi, H., & Niroomand, H. (2021) · International Journal of Reproductive BioMedicine (IJRM) · doi:10.18502/ijrm.v19i3.8571 · Cited by 33 · see citing works
Kaltsas, A., Giannakodimos, I., Markou, E., Stavropoulos, M., Deligiannis, D., Kratiras, Z., & Chrisofos, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136211 · Cited by 34 · see citing works
Keshtmand, Z., Akbaribazm, M., Bagheri, Y., & Oliaei, R. (2020) · Andrologia · doi:10.1111/and.13908 · Cited by 30 · see citing works
Semen Microbiome, Male Infertility, and Reproductive Health
Chatzokou, D., Tsarna, E., Davouti, E., Siristatidis, C. S., Christopoulou, S., Spanakis, N., Tsakris, A., & Christopoulos, P. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26041446 · Cited by 28 · see citing works
D’Argenio, V., Dittfeld, L., Lazzeri, P., Tomaiuolo, R., & Tasciotti, E. (2021) · Genes · doi:10.3390/genes12040605 · Cited by 24 · see citing works
The microbiome and male infertility: looking into the past to move forward
Alqawasmeh, O., Fok, K. L., Yim, H. C. H., Li, T. C., Chung, J. P. W., & Chan, D. Y. L. (2022) · Human Fertility · doi:10.1080/14647273.2022.2098540 · Cited by 23 · see citing works
Valcarce, D. G., Riesco, M. F., Martínez, J. M., & Robles, V. (2019) · Biomolecules · doi:10.3390/biom9080338 · Cited by 21 · see citing works
Shahid, M. N., Khan, T. M., Neoh, C. F., Lean, Q. Y., Bukhsh, A., & Karuppannan, M. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.638628 · Cited by 18 · see citing works
Iniesta, S., Esteban, S., Onica Armijo, S., Lobo, S., Manzano, S., Espinosa, I. A., Cárdenas, N., Bartha, J. L., & Jiménez, E. (2022) · American Journal of Reproductive Immunology · doi:10.1111/aji.13552 · Cited by 18 · see citing works
Microbial Gatekeepers of Fertility in the Female Reproductive Microbiome of Cattle
Adnane, M., & Chapwanya, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252010923 · Cited by 16 · see citing works
Pharmacological therapies for male infertility
Rambhatla, A., Shah, R. S., Pinggera, G., Mostafa, T., Atmoko, W., Saleh, R. A., Chung, E., Hamoda, T. A.-A. A.-M., Çayan, S., Park, H. J., et al. (2024) · Pharmacological Reviews · doi:10.1124/pharmrev.124.001085 · Cited by 17 · see citing works
Organski, A. C., Jorgensen, J. S., & Cross, T.-W. (2021) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2021.100284 · Cited by 16 · see citing works
Bruno, C., Basile, U., Vergani, E., Napodano, C., Oliva, A., Gulli, F., Meucci, E., Silvestrini, A., Orlando, P., Silvestri, S., et al. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12060857 · Cited by 17 · see citing works
Small intestinal bacterial overgrowth (SIBO) as a potential cause of impaired spermatogenesis
Tremellen, K. P., & Pearce, K. L. (2020) · Gut · doi:10.1136/gutjnl-2020-320766 · Cited by 16 · see citing works
Michaelsen, M. P., Poulsen, M., Bjerregaard, A. A., Borgstrøm, M. B., Poulsen, L., Chortsen, M., Henriksen, S., & Kesmodel, U. S. (2025) · Nutrients · doi:10.3390/nu17101710 · Cited by 15 · see citing works
Diabetic testicular dysfunction and spermatogenesis impairment: mechanisms and therapeutic prospects
Zhang, W., Tong, L., Jin, B., & Sun, D. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1653975 · Cited by 15 · see citing works
The Semen Microbiome and Semen Parameters in Healthy Stallions
Quiñones‐Pérez, C., Martínez, A. M., Ortíz, I., Crespo, F., & Vega-Pla, J. L. (2022) · Animals · doi:10.3390/ani12050534 · Cited by 15 · see citing works
Dubey, I., Nandheeswari, K., Vigneshwaran, G., Rohilla, G., Lalruatmawii, Naxine, P., Jayapradha, P., Rachamalla, M., & Kushwaha, S. (2024) · Reproductive Toxicology · doi:10.1016/j.reprotox.2024.108732 · Cited by 14 · see citing works
Jendraszak, M., Skibińska, I., Kotwicka, M., & Andrusiewicz, M. (2024) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2024.2331489 · Cited by 14 · see citing works
Probiotics supplementation in the treatment of male infertility: A Systematic Review
Oliveira, L. C. S. D. L., Costa, E. C., Martins, F. D. G., da Rocha, A. S., & Brasil, G. A. (2024) · JBRA · doi:10.5935/1518-0557.20240013 · Cited by 13 · see citing works
All Properties of Infertility Microbiome in a Review Article
Elahi, Z., Mokhtaryan, M., Mahmoodi, S., Shahroodian, S., Darbandi, T., Ghasemi, F., Ghanavati, R., & Darbandi, A. (2025) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.25158 · Cited by 13 · see citing works
Rodrigues, L. E., Kishibe, M. M., Keller, R., Caetano, H. R. D. S., Rufino, M. N., Sanches, O. D. C., Giometti, I. C., Giuffrida, R., & Bremer‐Neto, H. (2021) · Veterinary World · doi:10.14202/vetworld.2021.1210-1219 · Cited by 13 · see citing works
Hu, L., Zhao, Y., Liu, S., Zhang, J., Yuan, H., & Xu, H. (2022) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.12309 · Cited by 12 · see citing works
Beneficial Effects of Probiotics on Benign Gynaecological Disorders: A Review
Norfuad, F. A., Mokhtar, M. H., & Ghani, N. A. A. (2023) · Nutrients · doi:10.3390/nu15122733 · Cited by 12 · see citing works
The role of functional foods based on probiotics in improving fertility: A review
Khani, N., Ashkezary, M. R., Hosseinzadeh, N., Aghapour, B., Hosseini, A., Soleimani, R. A., Houshmandi, S., Shokouhian, S. M. J., & Rad, A. H. (2025) · Journal of Functional Foods · doi:10.1016/j.jff.2025.106871 · Cited by 11 · see citing works
Cavallini, G., Scroppo, F. I., & Colpi, G. M. (2018) · Andrology · doi:10.1111/andr.12556 · Cited by 11 · see citing works
Self-citationTremellen, K. P., & Pearce, K. L. (2017) · Andrology · doi:10.1111/andr.12400 · Cited by 10 · see citing works
Shaping Microbiota During the First 1000 Days of Life
Samarra, A., Ventura, E. F., Bernabeu, M., Cabrera‐Rubio, R., Bäuerl, C., Selma‐Royo, M., & Collado, M. C. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-58572-2_1 · Cited by 10 · see citing works
Exploring the microbiome-gut-testis axis in testicular germ cell tumors
Čierniková, S., Ševčíková, A., & Mego, M. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1529871 · Cited by 9 · see citing works
Microbiome–Maternal Tract Interactions in Women with Recurrent Implantation Failure
Kumar, M., Yan, Y., Jiang, L., Sze, C.-H., Kodithuwakku, S. P., Yeung, W. S. B., & Lee, C. (2025) · Microorganisms · doi:10.3390/microorganisms13040844 · Cited by 11 · see citing works
Hwang, Y.-Y., Sudirman, S., Hsu, Y.-C., Chen, C., Kong, F., Hwang, D., & Kong, Z. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26104533 · Cited by 9 · see citing works
Hashem, N. M., & Gonzalez‐Bulnes, A. (2022) · Reproduction Fertility and Development · doi:10.1071/rd21252 · Cited by 8 · see citing works
Unraveling the Intricacies of the Seminal Microbiome and Its Impact on Human Fertility
Corral-Vázquez, C., Blanco, J., Sarrate, Z., & Antón, E. (2024) · Biology · doi:10.3390/biology13030150 · Cited by 8 · see citing works
Asadi, M., Gholipour, F., Rahavian, A., & Javanbakht, M. (2023) · Journal of Research in Medical Sciences · doi:10.4103/jrms.jrms_392_23 · Cited by 7 · see citing works
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Gomes, I. D. A., Monteiro, P. B., de Moura, G. A., Santos, N. O., Fontanezi, C. T. B., de Souza, S. V., & Teixeira, C. A. D. (2023) · JBRA · doi:10.5935/1518-0557.20230008 · Cited by 7 · see citing works
The role and challenges of regulating endometrial microbiome in uterine health and diseases
Yuan, C., Xie, K., Feng, L., Gao, S., & Cai, L. (2024) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2024.2320247 · Cited by 6 · see citing works
Effect of Probiotics on Sperm Quality in the Adult Mouse
Sánchez-Rodríguez, A., Idrovo, I. I. D., Villafranca, R., Latorre, N., Rielo, J. A., Laburu, A., Nieto-Román, S., Heredia, D., González, R., García‐Cañas, V., et al. (2024) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-024-10388-z · Cited by 5 · see citing works
Raimundo, J. M., Rodrigues, P. I. D. L., Esteban, S., Espinosa‐Martos, I., & Jiménez, E. (2025) · Nutrients · doi:10.3390/nu17030410 · Cited by 4 · see citing works
Study of antibiotics and symbiotic effects on sperm quality using the CASA system
Bouchicha, A. E. B., Kalem, A., Mimoune, N., Djouadi, S., Khelef, D., & Kaidi, R. (2021) · Veterinarska stanica · doi:10.46419/vs.53.4.2 · Cited by 4 · see citing works
A Retrospective Narrative Mini-Review Regarding the Seminal Microbiota in Infertile Male
Doroftei, B., Ilie, O., Dabuleanu, A., Huțanu, D., & Văduva, C.-C. (2022) · Medicina · doi:10.3390/medicina58081067 · Cited by 4 · see citing works
Mändar, R., Smidt, I., Rööp, T., Hoidmets, D., Kilk, K., Zilmer, M., Ausmees, K., & Salumets, A. (2025) · Andrologia · doi:10.1155/and/7000428 · Cited by 3 · see citing works
Impact of Moriamin Forte on Testicular and Epididymal Damage in Rats with Oligoasthenospermia
Zhou, X. W., Zhang, G., Liang, W.-N., Li, Y., Xu, S. H., Yan, L., Li, H., & Shang, X. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/4059248 · Cited by 3 · see citing works
Bayat, M., Koohpeyma, F., Montazeri‐Najafabady, N., Dabbaghmanesh, M. H., Asmarian, N., & Hosseini, S. Y. (2024) · International Urology and Nephrology · doi:10.1007/s11255-024-04243-x · Cited by 3 · see citing works
Melhem, S. J., Melhem, M., Haddad, R., Alghurabi, O., Mousa, R., Massad, E. M., Almomani, H., Alrashdan, Y., & Melhem, J. (2026) · Andrology · doi:10.1111/andr.70266 · Cited by 2 · see citing works
İdiyopatik erkek infertilitesinde probiyotiklerin yeri
Akgül, T., Doğantekin, E., & Ağras, K. (2019) · Androloji Bülteni · doi:10.24898/tandro.2019.57442 · Cited by 2 · see citing works
Using Selenium-enriched Mutated Probiotics as Enhancer for Fertility Parameters in Mice
Darwish, A. M., Almehizia, A. A., Khattab, A. E.-N. A., Sharaf, H. A., Naglah, A. M., Bhat, M. A., Zen, A. A., & Kalmouch, A. (2024) · Biological Trace Element Research · doi:10.1007/s12011-024-04067-x · Cited by 2 · see citing works
Infertilidade masculina: principais causas e terapêuticas emergentes, uma revisão
Marconato, T. C., Donne, R. D. D., Romano, R. M., & Romano, M. A. (2022) · Research Society and Development · doi:10.33448/rsd-v11i10.33139 · Cited by 1 · see citing works
Getachew, T., Ashenafi, M., Tigu, F., Birri, D. J., Naoli, A., & Desalegn, A. (2025) · BMC Microbiology · doi:10.1186/s12866-025-04326-4 · Cited by 1 · see citing works
Positioning nutrigenomics and nutrigenetics within the framework of male infertility exploration
Nkansah, E. O., Xu, B., Lan, Y., & Zafar, M. I. (2025) · Reproductive Toxicology · doi:10.1016/j.reprotox.2025.109043 · Cited by 1 · see citing works
Altınöz, E., Cinar, D., Biçer, Y., Ozturk, I., Üğe, M., Sahin, M. M., & Çolak, T. (2026) · Biological Rhythm Research · doi:10.1080/09291016.2026.2659743 · Cited by 1 · see citing works
Relationships between biological aging and male reproductive monitors
Scroppo, F. I., & Cavallini, G. (2019) · Asian Journal of Andrology · doi:10.4103/aja.aja_27_19 · Cited by 1 · see citing works
Self-citationPrebiotics for people with cystic fibrosis
Williams, N. C., Jayaratnasingam, J., Prayle, A., Nevitt, S. J., & Smyth, A. R. (2023) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd015236.pub2 · Cited by 1 · see citing works
Multiomics Reveals the Microbiota and Metabolites Associated with Sperm Quality in Rongchang Boars
Chao, A., Zhang, B., Chai, R., Tu, Z., Yan, Z., Wu, X., Wei, M., Wu, C., Zhang, T., Wu, P., et al. (2024) · Microorganisms · doi:10.3390/microorganisms12061077 · Cited by 1 · see citing works
Tremellen, K. (2020) · Springer eBooks · doi:10.1007/978-3-030-32300-4_45 · Cited by 2 · see citing works
Hechtman, L. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-43044-9.00185-0 · Cited by 1 · see citing works
مروری بر اثرات مفید پروبیوتیک ها در پیشگیری و درمان بیماریها
Safdari, M., Razi, A., Safarirad, M., Pournaghi, S.-J., Shekari, S., Alesheikh, P., & Rameshrad, M. (2021) · Journal of North Khorasan University of Medical Sciences · doi:10.29252/nkjms-13019
İnfertiliteye Yeni Bir Bakış Açısı: Mikrobiyota
Özyer, K., & Kemaneci, S. (2024) · İzmir Katip Çelebi Üniversitesi Sağlık Bilimleri Fakültesi Dergisi · doi:10.61399/ikcusbfd.1219405
Microbiome Testing in Male Infertility
Anifandis, G., Messini, C. I., Chatzimeletiou, K., Daponte, A. I., & Messinis, I. E. (2023) · Springer eBooks · doi:10.1007/978-981-99-7028-5_5
Antibiotic therapy of male infertility
Mostafa, T., Abdel‐Hamid, I. A., & Zohdy, W. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-93047-5.00026-x
Successful Conception Following Probiotic Intervention in Males with Semen Dysbiosis: A Case SeriesPreprint
Gupte, S., Shah, A. S., Kirdat, K., Arora, P., Jangam, S., Jadhav, S., Pachang, P., Singh, S. K., Shah, S., & Joshi, A. (2025) · Research Square · doi:10.21203/rs.3.rs-6083315/v1
Najjar, A., Saïd, S. B., & Samti, H. (2025) · Acta Veterinaria Hungarica · doi:10.1556/004.2025.01218
Infertility and the microbiota
Zhang, L., Wang, T., Zhu, N., Li, C., Zhang, X., 焦永慧, Li, G., & Jiapaer, Z. (2026) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2026.104839
Effects of Nonhormonal Medical Treatment on Male Fertility
Calogero, A. E., Condorelli, R. A., Cannarella, R., & Vignera, S. L. (2026) · Endocrinology · doi:10.1007/978-3-319-29456-8_37-2
Probiotic supplementation in men with asthenozoospermia: A randomized controlled trial
Moshkdanian, G., Toghraiee, M., Bafrani, H. H., Ahaz, F. Z., & Kashani, H. (2026) · Asian Pacific Journal of Reproduction · doi:10.4103/apjr.apjr_91_25
Effects of probiotics intervention on sperm parameters: A systematic review on literature
Shamsi‐Goushki, A., Mahmoodi, M. R., Ashourzadeh, S., Jazinaki, M. S., & Rezvani, R. (2026) · Nutrition and Health · doi:10.1177/02601060261464829
Borate, S. J., Puran, L. M., Gujare, M. G., Wanjale, S. A., & Khan, A. H. (2026) · Asian Journal of Pharmacy and Technology · doi:10.52711/2231-5713.2026.00039
Gut microbiota as master regulators: Mapping gut-organ axes that orchestrate systemic health
Han, B., Kang, M., Huang, W., Lan, Y., Tong, S., Liu, S., Chen, S., Wen, H., Li, Y., & Tang, D. (2026) · TransMed · doi:10.1016/j.tmed.2026.100042
- Authors
- Maretti, C., & Cavallini, G.
- Affiliations
- GynePro Medical (IT)
- Corresponding author
- Cavallini, G.
- ORCID
- Cavallini, G.
- Venue
- Andrology
- Publisher
- Wiley
- Published
- 2017-02-28
- Volume
- 5
- Issue
- 3
- Pages
- 439-444
- ISSN
- 2047-2919 (ISSN-L)
- 2047-2927
- OpenAlex
- W2592263560
- Cited by
- 103
- References
- 17
- Citations by year
- 2026: 11 · 2025: 15 · 2024: 19 · 2023: 8 · 2022: 14 · 2021: 9 · 2020: 13 · 2019: 8 · 2018: 3 · 2017: 3
- FWCI
- 8.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Andrology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Keywords
- probiotics, prebiotics, Lactobacillus paracasei, arabinogalactan, glutamine, male infertility, semen quality, sperm count, sperm motility, semen morphology, semen volume, androgen levels, follicle-stimulating hormone, luteinizing hormone, testosterone, estradiol, prolactin
- MeSH terms
- Adult, Double-Blind Method, Humans, Male, Oligospermia, Pilot Projects, Spermatozoa, Probiotics, Semen Analysis, Prebiotics
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