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Effect of early probiotic supplementation on childhood cognition, behaviour and mood a randomised, placebo‐controlled trial
Abstract
Aim: To determine whether probiotic supplementation in early life improves neurocognitive outcomes assessed at 11 years of age. Methods: A total of 474 children who were born March 2004–Aug 2005 participated in a two‐centre randomised placebo‐controlled trial of infants at risk of developing allergic disease. Pregnant women were randomised to take Lactobacillus rhamnosus strain HN001, Bifidobacterium animalis subsp. lactis strain HN019 or placebo daily from 35 weeks gestation until six months if breastfeeding, and their infants the same treatment from birth to two years. Intelligence, executive function, attention, depression and anxiety were assessed when the children were 11 years of age. Results: A total of 342 (72.2%) children were assessed (HN001 n = 109, HN019 n = 118 and placebo n = 115). Overall, there were no significant differences in the neurocognitive outcomes between the treatment groups. Conclusion: HN001 and HN019 given in early life were not associated with neurocognitive outcomes at 11 years of age in this study. However, we cannot exclude that other probiotics may have a beneficial effect. Further clinical trials are indicated.
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“although a recent study of post-natal probiotics (L.rhamnosus HN001 or B. animalis HN019) found no effect of either strain on later neurocognitive outcomes (Slykerman et al., 2018).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Slykerman et al., 2018
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Metadata
- Authors
- Slykerman, R. F., Kang, J., Van Zyl, N., Barthow, C., Wickens, K., Stanley, T., Coomarasamy, C., Purdie, G., Murphy, R., Crane, J., & Mitchell, E. A.
- Affiliations
- Department of Psychological Medicine University of Auckland Auckland New Zealand
- Department of Medicine University of Otago Wellington New Zealand
- Department of Paediatrics: Child and Youth Health University of Auckland Auckland New Zealand
- Department of Paediatrics University of Otago Wellington New Zealand
- Dean's Office University of Otago Wellington New Zealand
- Department of Medicine University of Auckland Auckland New Zealand
- ORCID
- Slykerman, R F
- Venue
- Acta Paediatrica
- Publisher
- Wiley
- Published
- 2018-10-22
- Volume
- 107
- Issue
- 12
- Pages
- 2172-2178
- ISSN
- 0803-5253
- 1651-2227
- Cited by
- 60
- References
- 8
- Language
- en
- Funders
- Cure Kids
- Fonterra Co-operative Group
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- Slykerman, R. F., Kang, J., Van Zyl, N., Barthow, C., Wickens, K., Stanley, T., Coomarasamy, C., Purdie, G., Murphy, R., Crane, J., & Mitchell, E. A. (2018). Effect of early probiotic supplementation on childhood cognition, behaviour and mood a randomised, placebo‐controlled trial. Acta Paediatrica. https://doi.org/10.1111/apa.14590