CoChat
Sign Up
Cited by 389Muscle Physiology and DisordersMuscle metabolism and nutritionSports Performance and Training

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Architectural, functional and molecular responses to concentric and eccentric loading in human skeletal muscle

Open access
Franchi, M. V., Atherton, P. J., Reeves, N. D., Flück, M., Williams, J., Mitchell, W. K., Selby, A., Beltran Valls, R. M., Narici, M. V.·2014·Acta Physiologica
DOI 10.1111/apha.12225
Open this paper in CoChat — free accountOpen PDF

Abstract

Aim: We investigated architectural, functional and molecular responses of human skeletal muscle to concentric (CON) or eccentric (ECC) resistance training (RT). Methods: Twelve young males performed 10 weeks of concentric (CON) or eccentric (ECC) resistance training (RT) (n = 6 CON, 6 ECC). An additional 14 males were recruited to evaluate acute muscle fascicle behaviour and molecular signalling in biopsies collected from vastus lateralis (VL) after 30 min of single bouts of CON or ECC exercise. VL volume was measured by magnetic resonance imaging. Muscle architecture (fascicle length, Lf; pennation angle, PA) was evaluated by ultrasonography. Muscle remodelling signals to CON or ECC loading [MAPK/AKT‐mammalian target of rapamycin (mTOR) signalling] and inflammatory pathway (TNFαMurf‐1‐MAFbx) were evaluated by immunoblotting. Results: Despite the ~1.2‐fold greater load of the ECC group, similar increases in muscle volume (+8% CON and +6% ECC) and in maximal voluntary isometric contraction (+9% CON and +11% ECC) were found after RT. However, increases in Lf were greater after ECC than CON (+12 vs. +5%) while increases in PA were greater in CON than ECC (+30 vs. +5%). Distinct architectural adaptations were associated with preferential growth in the distal regions of VL for ECC (+ECC +8% vs. +CON +2) and mid belly for CON (ECC +7 vs. CON +11%). While MAPK activation (p38MAPK, ERK1/2, p90RSK) was specific to ECC, neither mode affected AKT‐mTOR or inflammatory signalling 30 min after exercise. Conclusion: Muscle growth with CON and ECC RT occurs with different morphological adaptations reflecting distinct fibre fascicle behaviour and molecular responses.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1111/apha.12225

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Cited by

Sorted by citations

See all 389

Related

See all

Metadata

Authors
Franchi, M. V., Atherton, P. J., Reeves, N. D., Flück, M., Williams, J., Mitchell, W. K., Selby, A., Beltran Valls, R. M., & Narici, M. V.
Affiliations
  • Manchester Metropolitan University (GB)
  • University of Nottingham (GB)
  • University of Zurich (CH)
  • School of Graduate Entry Medicine and Health MRC‐ARUK Centre of Excellence for Musculoskeletal Ageing Research University of Nottingham Derby UK
Corresponding author
Franchi, M. V.
ORCID
Venue
Acta Physiologica
Publisher
Wiley
Published
2014-02-06
Volume
210
Issue
3
Pages
642-654
ISSN
  • 1748-1708 (ISSN-L)
  • 1748-1716
DOI
10.1111/apha.12225
OpenAlex
W2137572960
Cited by
389
References
42
Citations by year
2026: 15 · 2025: 39 · 2024: 39 · 2023: 31 · 2022: 37 · 2021: 43 · 2020: 39 · 2019: 36 · 2018: 33 · 2017: 36 · 2016: 24 · 2015: 13 · 2014: 3
FWCI
10.38
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Acta Physiologica (publishedVersion)
  • PubMed (publishedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
  • e-space (Manchester Metropolitan University) (acceptedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
  • Lancaster EPrints (Lancaster University) (submittedVersion)
  • Repositori UJI (Universitat Jaume I) (submittedVersion, public-domain)
  • Padua Research Archive (University of Padova) (submittedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
Funders
Medical Research Council (MR/K00414X/1)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Keywords
eccentric loading, concentric loading, resistance training, skeletal muscle architecture, fascicle length, pennation angle, vastus lateralis, muscle volume, MAPK signaling, Akt/mTOR signaling, muscle remodeling, acute exercise response, p38 MAPK, ERK1/2, p90RSK
MeSH terms
Adaptation, Physiological, Adult, Electromyography, Humans, Male, Muscle Contraction, Immunoblotting, Muscle, Skeletal, p38 Mitogen-Activated Protein Kinases, Mitogen-Activated Protein Kinase 3, Muscle Strength, Resistance Training, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review