CoChat
Sign Up
Cited by 65Liver Disease and TransplantationLiver physiology and pathologyAlcohol Consumption and Health Effects

Soluble CD 163 and soluble mannose receptor predict survival and decompensation in patients with liver cirrhosis, and correlate with gut permeability and bacterial translocation

Open access
Rainer, F., Horvath, A., Sandahl, T. D., Leber, B., Schmerboeck, B., Blesl, A., Groselj‐Strele, A., Stauber, R. E. +5 more·2018·Alimentary Pharmacology & Therapeutics
DOI 10.1111/apt.14474PMC PMC6333289
Open this paper in CoChat — free account

Abstract

Summary: Background: Activated hepatic macrophages play a key role in inflammation and fibrosis progression in chronic liver disease. Aim: To assess the prognostic value of soluble (s)CD 163 and mannose receptor (sMR) in cirrhotic patients and explore associations with markers of intestinal permeability (lactulose‐mannitol ratio, diamine oxidase), bacterial translocation (endotoxin, lipopolysaccharide‐binding protein) and markers of systemic immune activation (interleukin‐6, interleukin‐8, sCD 14). Methods: We prospectively investigated 101 cirrhotic patients (Child‐Pugh class A: n = 72, Child‐Pugh classes B and C: n = 29) and 31 healthy controls. Patients were observed for a median follow‐up of 37 months. Results: Median plasma levels of sCD163 and soluble mannose receptor were significantly elevated in cirrhotic patients (P < .001) and increased with disease severity (sCD163 in healthy controls = 1.3, Child‐Pugh class A = 4.2, Child‐Pugh classes B and C = 8.4 mg/L; sMR in healthy controls = 15.8, Child‐Pugh class A = 36.5, Child‐Pugh classes B and C = 66.3 μg/dL). A total of 21 patients died during the observation period. Patients with sCD163 levels above 5.9 mg/L showed significantly reduced survival (survival rate after 36 months: 71% versus 98%, P < .001). Patients with soluble mannose receptor levels above 45.5 μg/dL developed significantly more complications of cirrhosis within 12 months (73% versus 9%, P < .001). Furthermore, both variables correlated with the lactulose‐mannitol ratio, diamine oxidase, lipopolysaccharide and interleukin‐8. Conclusion: Our data demonstrate the prognostic value of sCD 163 in predicting long‐term survival in patients with liver cirrhosis and identify soluble mannose receptor as a prognostic marker for occurrence of cirrhosis‐associated complications. The correlation between gut barrier dysfunction and activation of macrophages points towards a link between them.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1111/apt.14474

Cites

37 of 37 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The gut may play an indispensable role in the progression of sepsis and multiple organ dysfunction, contributing to epithelial cell apoptosis and barrier impairment and promoting bacterial translocation.

    “previous reports highlighted that the gut might play an indispensable role in the progression of sepsis and multiple organ dysfunction, contributing to epithelial cell apoptosis and barrier impairment and promoting bacterial translocation (Yang et al., 2019; Wang et al., 2015; Rainer et al., 2018; Bajaj et al., 2017).”

    From The modulatory effects of gut microbes and metabolites on blood-brain barrier integrity and brain function in sepsis-associated encephalopathy (2023) · cites this paper as Rainer et al., 2018

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 1

  1. [19]Child CG Turcotte JG Surgery and portal hypertension The Liver and Portal Hypertension Philadelphia Saunders 1964 50 64

Cited by

Sorted by citations

Authors
Rainer, F., Horvath, A., Sandahl, T. D., Leber, B., Schmerboeck, B., Blesl, A., Groselj‐Strele, A., Stauber, R. E., Fickert, P., Stiegler, P., Møller, H. J., Grønbæk, H., & Stadlbauer, V.
Affiliations
  • Medical University of Graz (AT)
  • Departments of Hepatology and Gastroenterology, and Clinical Biochemistry Denmark
Corresponding author
Rainer, F.
ORCID
Venue
Alimentary Pharmacology & Therapeutics
Publisher
Wiley
Published
2017-12-21
Volume
47
Issue
5
Pages
657-664
ISSN
  • 0269-2813 (ISSN-L)
  • 1365-2036
DOI
10.1111/apt.14474
PMC
PMC6333289
OpenAlex
W2781085476
Cited by
65
References
37
Citations by year
2026: 3 · 2025: 6 · 2024: 8 · 2023: 7 · 2022: 8 · 2021: 14 · 2020: 10 · 2019: 4 · 2018: 5
FWCI
3.20
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Alimentary Pharmacology & Therapeutics (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Austrian Science Fund (P 24362)
  • Österreichische Forschungsförderungsgesellschaft (854419/6497141)
  • Strategiske Forskningsråd (TRAIN 10‐092797)
  • Savvaerksejer Jeppe Juhl og Hustru Ovita Juhls Mindelegat
  • Novo Nordisk
Topics
  • Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords
liver cirrhosis, soluble CD163, hepatic macrophages, prognostic factors, survival, decompensation, intestinal permeability, bacterial translocation, lactulose/mannitol ratio, diamine oxidase, lipopolysaccharide, interleukin-8, systemic immune activation, intestinal barrier dysfunction, Child-Pugh score
MeSH terms
Mannose Receptor, CD163 Antigen, Aged, Female, Humans, Intestinal Mucosa, Intestines, Liver Cirrhosis, Male, Middle Aged, Permeability, Prognosis, Receptors, Cell Surface, Antigens, Differentiation, Myelomonocytic, Biomarkers, Antigens, CD, Case-Control Studies, Liver Failure, Bacterial Translocation, Lectins, C-Type, Mannose-Binding Lectins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review