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Cited by 61Liver Disease Diagnosis and TreatmentPhysical Activity and HealthAlcohol Consumption and Health Effects

Vigorous physical activity provides protection against all‐cause deaths among adults patients with nonalcoholic fatty liver disease (NAFLD)

Henry, Austin, Paik, James M., Austin, Patrick, Eberly, Katherine Elizabeth, Golabi, Pegah, Younossi, Issah, Henry, Linda, Gerber, Lynn +1 more·2023·Alimentary Pharmacology & Therapeutics
DOI 10.1111/apt.17308
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Abstract

BACKGROUND: Mortality benefits of vigorous leisure time physical activity (LTPA) among adults with NAFLD is not known. AIM: To investigate association between LTPA and reduction in all-cause mortality among adults with NAFLD. METHODS: We used NHANES (1999-2006) self-reported PA data for adults (≥40 years) with mortality follow-up through December 31, 2015. US-Fatty Liver Index in absence of secondary causes identified NAFLD. Moderate and vigorous LTPA were calculated by the 2018 PA Guidelines for Americans. RESULTS: NAFLD prevalence among 5211 adults (46.2% male; 75.8% white; mean age 53.2 years) was 32.7%. Adults with NAFLD were less likely to report the recommended minimal PA (≥ 150 min/week, 55.5% vs 64.8%) or highly active PA (≥300 min/week, 39.2% vs 48.5%) compared to adults without NAFLD. Over a median follow-up of 12.3 years, 355 deaths among adults with NAFLD and 510 deaths among adults without NAFLD were registered. In the metabolic comorbidities-adjusted model, adults with NAFLD who reported ≥50% of their total PA as vigorous activity had a 56% reduction in all-cause mortality risk (HR:0.44, 95%CI: 0.25-0.76) and cancer-specific mortality risk (HR: 0.21, 0.06-0.66) but not cardiac-specific mortality (p > 0.05) compared to adults with NAFLD who did not report any LTPA. This association remained significant even among adults with NAFLD who met the recommended minimal PA, among adults with NAFLD who reported any LTPA, and among adults with NAFLD who had metabolic abnormalities and in sensitivity analysis. CONCLUSIONS: Engaging in vigorous activity is beneficial for adults with NAFLD - especially those with metabolic abnormalities.

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  • Several observational studies have demonstrated that regular increased physical activity is associated with reduced risk for liver fibrosis (measured by non-invasive markers), cirrhosis, all-cause mortality and HCC.

    “Furthermore, several observational studies have demonstrated that regular increased physical activity is associated with reduced risk for liver fi brosis (measured by non-invasive markers), cirrhosis, allcause mortality 322 -324 and HCC. 325”

    From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [324]

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Authors
Henry, A., Paik, J. M., Austin, P., Eberly, K. E., Golabi, P., Younossi, I., Henry, L., Gerber, L., & Younossi, Z. M.
Affiliations
  • Inova Health System (US)
  • Center for Outcomes Research in Liver Diseases (US)
Corresponding author
Younossi, Zobair M.
ORCID
Venue
Alimentary Pharmacology & Therapeutics
Publisher
Wiley
Published
2022-11-15
Volume
57
Issue
6
Pages
709-722
ISSN
  • 0269-2813 (ISSN-L)
  • 1365-2036
DOI
10.1111/apt.17308
OpenAlex
W4309107151
Cited by
61
References
56
Citations by year
2026: 11 · 2025: 19 · 2024: 20 · 2023: 11
FWCI
9.03
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Alimentary Pharmacology & Therapeutics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords
non-alcoholic fatty liver disease, high-intensity exercise, leisure-time physical activity, all-cause mortality, cancer-specific mortality, cardiac mortality, metabolic comorbidities, physical activity guidelines, NHANES
MeSH terms
Adult, Female, Humans, Male, Middle Aged, Motor Activity, Nutrition Surveys, United States, Exercise, Comorbidity, Non-alcoholic Fatty Liver Disease

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