Cited by 32Hematopoietic Stem Cell TransplantationRenal Transplantation Outcomes and TreatmentsTransplantation: Methods and Outcomes

New perspectives on the use of mTOR inhibitors in allogeneic haematopoietic stem cell transplantation and graft‐versus‐host disease

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Lutz, Mathias, Mielke, Stephan·2016·British Journal of Clinical Pharmacology

Abstract

Inhibition of the mechanistic target of rapamycin (mTOR) has been exploited largely both in solid tumour oncology and solid organ transplantation. More recently mTOR inhibitors such as sirolimus and everolimus have been introduced to the field of allogeneic haematopoietic stem cell transplantation where their unique combination of immunosuppressive purposes offering reduced nephrotoxicity and potential antimalignant effects reflect a unique drug profile that has led to their widespread use in both prophylaxis and therapy of graft‐versus‐host disease (GVHD). On the other hand haematological insufficiency, infectious complications as well as vasculopathies, have been frequently reported as limiting toxicities. Here, we review both the retrospective and prospective experience available to date and stress the need for prospective registration trials to reduce off label use and improve patient safety by optimizing dosing and enhancing pharmacovigilance. Furthermore, we speculate on the future role of mTOR inhibitors in allogeneic haematopoietic stem cell transplantation.

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Crossref · 10.1111/bcp.13022

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  • Rapamycin has been extensively utilized for transplant rejection prophylaxis and graft-versus-host disease, as well as seizure control and reduction of tumors in tuberous sclerosis complex patients.

    “Rapamycin has been extensively utilized for transplant rejection prophylaxis and graft-versus-host disease, as well as seizure control and reduction of tumors in tuberous sclerosis complex patients [499–501].”

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Authors
Lutz, M., & Mielke, S.
Affiliations
  • University of Münster (DE)
  • University of Würzburg (DE)
Corresponding author
Mielke, Stephan
Venue
British Journal of Clinical Pharmacology
Publisher
Wiley
Published
2016-06-22
Volume
82
Issue
5
Pages
1171-1179
ISSN
  • 0306-5251 (ISSN-L)
  • 1365-2125
OpenAlex
W2418028176
Cited by
32
References
76
Citations by year
2026: 1 · 2025: 1 · 2023: 2 · 2022: 4 · 2021: 6 · 2020: 6 · 2019: 3 · 2018: 5 · 2017: 2 · 2016: 2
FWCI
0.57
Type
journal article
Language
en
Open access
Locations
  • British Journal of Clinical Pharmacology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
  • Health Sciences › Medicine › Transplantation › Renal Transplantation Outcomes and Treatments
  • Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
Keywords
mTOR inhibitors, rapamycin, everolimus, allogeneic hematopoietic stem cell transplantation, graft-versus-host disease, immunosuppression, nephrotoxicity, infectious complications, vasculopathy, pharmacovigilance, off-label drug use, dose optimization
MeSH terms
Graft vs Host Disease, Humans, Immunosuppressive Agents, Hematopoietic Stem Cell Transplantation, TOR Serine-Threonine Kinases

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