The DOI matches its Crossref record; 130 of the 132 references it cites were found in a registry or an index.
The Neuropathology of Chronic Traumatic Encephalopathy
Open accessAbstract
Repetitive brain trauma is associated with a progressive neurological deterioration, now termed as chronic traumatic encephalopathy ( CTE ). Most instances of CTE occur in association with the play of sports, but CTE has also been reported in association with blast injuries and other neurotrauma. Symptoms of CTE include behavioral and mood changes, memory loss, cognitive impairment and dementia. Like many other neurodegenerative diseases, CTE is diagnosed with certainty only by neuropathological examination of brain tissue. CTE is a tauopathy characterized by the deposition of hyperphosphorylated tau (p‐tau) protein as neurofibrillary tangles, astrocytic tangles and neurites in striking clusters around small blood vessels of the cortex, typically at the sulcal depths. Severely affected cases show p‐tau pathology throughout the brain. Abnormalities in phosphorylated 43 k D a TAR DNA ‐binding protein are found in most cases of CTE ; beta‐amyloid is identified in 43%, associated with age. Given the importance of sports participation and physical exercise to physical and psychological health as well as disease resilience, it is critical to identify the genetic risk factors for CTE as well as to understand how other variables, such as stress, age at exposure, gender, substance abuse and other exposures, contribute to the development of CTE .
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“Unlike Alzheimer's, beta-amyloid plaques are uncommon in CTE.191,192”
From 2023 Alzheimer's disease facts and figures (2023) · cites this paper as [191]
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“Like Alzheimer's disease, CTE is characterized by tangles of an abnormal form of the protein tau in the brain.”
From 2023 Alzheimer's disease facts and figures (2023) · cites this paper as [191]
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Cited by
Sorted by citations
2023 Alzheimer's disease facts and figures
(2023) · Alzheimer's & Dementia · doi:10.1002/alz.13016 · Cited by 3,212
Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research
Maas, A. I. R., Menon, D. K., Adelson, P. D., Andelic, N., Bell, M. J., Belli, A., Bragge, P., Brazinova, A., Büki, A., Chesnut, R. M., et al. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30371-x · Cited by 2,609
Brown, R. H., & Al‐Chalabi, A. (2017) · New England Journal of Medicine · doi:10.1056/nejmra1603471 · Cited by 2,580
2019 Alzheimer’s disease facts and figures.
Alzheimer's Association (2019) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2019.01.010 · Cited by 2,461
2022 Alzheimer's disease facts and figures
Anonymous (2022) · Alzheimer s & Dementia · doi:10.1002/alz.12638 · Cited by 2,469
Metadata
- Authors
- McKee, A. C., Stein, T. D., Kiernan, P. T., & Alvarez, V. E.
- Affiliations
- Boston University (US)
- Venue
- Brain Pathology
- Publisher
- Wiley
- Published
- 2015-04-23
- Volume
- 25
- Issue
- 3
- Pages
- 350-364
- ISSN
- 1015-6305 (ISSN-L)
- 1750-3639
- PMC
- PMC4526170
- OpenAlex
- W1888623186
- Cited by
- 585
- References
- 132
- Citations by year
- 2026: 37 · 2025: 62 · 2024: 60 · 2023: 53 · 2022: 45 · 2021: 63 · 2020: 44 · 2019: 69 · 2018: 49 · 2017: 50 · 2016: 39 · 2015: 12
- FWCI
- 6.50
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain Pathology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (1UO1NS086659-01)
- Department of Defense
- Department of Veterans Affairs
- National Institute of Aging (P30AG13846)
- NFL
- NOCSAE
- Sports Legacy Institute
- WWE
- Topics
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- chronic traumatic encephalopathy, repetitive head trauma, tauopathy, hyperphosphorylated tau, neurofibrillary tangles, amyloid-beta, sports-related brain injury, blast injury, neurodegeneration, genetic risk factors, neuropathology
- MeSH terms
- Neuropathology, Brain, DNA-Binding Proteins, Humans, tau Proteins, Brain Injury, Chronic
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