Cited by 588Traumatic Brain Injury ResearchAlzheimer's disease research and treatmentsTraumatic Brain Injury and Neurovascular Disturbances

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The Neuropathology of Chronic Traumatic Encephalopathy

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McKee, Ann C., Stein, Thor D., Kiernan, Patrick T., Alvarez, Victor E.·2015·Brain Pathology

DOI 10.1111/bpa.12248PMC PMC4526170

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Abstract

Repetitive brain trauma is associated with a progressive neurological deterioration, now termed as chronic traumatic encephalopathy ( CTE ). Most instances of CTE occur in association with the play of sports, but CTE has also been reported in association with blast injuries and other neurotrauma. Symptoms of CTE include behavioral and mood changes, memory loss, cognitive impairment and dementia. Like many other neurodegenerative diseases, CTE is diagnosed with certainty only by neuropathological examination of brain tissue. CTE is a tauopathy characterized by the deposition of hyperphosphorylated tau (p‐tau) protein as neurofibrillary tangles, astrocytic tangles and neurites in striking clusters around small blood vessels of the cortex, typically at the sulcal depths. Severely affected cases show p‐tau pathology throughout the brain. Abnormalities in phosphorylated 43 k D a TAR DNA ‐binding protein are found in most cases of CTE ; beta‐amyloid is identified in 43%, associated with age. Given the importance of sports participation and physical exercise to physical and psychological health as well as disease resilience, it is critical to identify the genetic risk factors for CTE as well as to understand how other variables, such as stress, age at exposure, gender, substance abuse and other exposures, contribute to the development of CTE .

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Authors: McKee, A. C., Stein, T. D., Kiernan, P. T., & Alvarez, V. E.
Affiliations: Boston University (US)
ORCID: McKee, Ann C.
Stein, Thor D.
Kiernan, Patrick T.
Venue: Brain Pathology
Publisher: Wiley
Published: 2015-04-23
Volume: 25
Issue: 3
Pages: 350-364
ISSN: 1015-6305 (ISSN-L)
1750-3639
DOI: 10.1111/bpa.12248
PMC: PMC4526170
OpenAlex: W1888623186
Cited by: 585
References: 132
Citations by year: 2026: 37 · 2025: 62 · 2024: 60 · 2023: 53 · 2022: 45 · 2021: 63 · 2020: 44 · 2019: 69 · 2018: 49 · 2017: 50 · 2016: 39 · 2015: 12
FWCI: 6.50
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Brain Pathology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Neurological Disorders and Stroke (1UO1NS086659-01)
Department of Defense
Department of Veterans Affairs
National Institute of Aging (P30AG13846)
NFL
NOCSAE
Sports Legacy Institute
WWE
Topics: Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords: chronic traumatic encephalopathy, repetitive head trauma, tauopathy, hyperphosphorylated tau, neurofibrillary tangles, amyloid-beta, sports-related brain injury, blast injury, neurodegeneration, genetic risk factors, neuropathology
MeSH terms: Neuropathology, Brain, DNA-Binding Proteins, Humans, tau Proteins, Brain Injury, Chronic

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