Cited by 588Traumatic Brain Injury ResearchAlzheimer's disease research and treatmentsTraumatic Brain Injury and Neurovascular Disturbances

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The Neuropathology of Chronic Traumatic Encephalopathy

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McKee, Ann C., Stein, Thor D., Kiernan, Patrick T., Alvarez, Victor E.·2015·Brain Pathology

DOI 10.1111/bpa.12248PMC PMC4526170

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Abstract

Repetitive brain trauma is associated with a progressive neurological deterioration, now termed as chronic traumatic encephalopathy ( CTE ). Most instances of CTE occur in association with the play of sports, but CTE has also been reported in association with blast injuries and other neurotrauma. Symptoms of CTE include behavioral and mood changes, memory loss, cognitive impairment and dementia. Like many other neurodegenerative diseases, CTE is diagnosed with certainty only by neuropathological examination of brain tissue. CTE is a tauopathy characterized by the deposition of hyperphosphorylated tau (p‐tau) protein as neurofibrillary tangles, astrocytic tangles and neurites in striking clusters around small blood vessels of the cortex, typically at the sulcal depths. Severely affected cases show p‐tau pathology throughout the brain. Abnormalities in phosphorylated 43 k D a TAR DNA ‐binding protein are found in most cases of CTE ; beta‐amyloid is identified in 43%, associated with age. Given the importance of sports participation and physical exercise to physical and psychological health as well as disease resilience, it is critical to identify the genetic risk factors for CTE as well as to understand how other variables, such as stress, age at exposure, gender, substance abuse and other exposures, contribute to the development of CTE .

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Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123
Staging of brain pathology related to sporadic Parkinson’s disease
Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777
A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β
Iliff, J. J., Wang, M., Liao, Y., Plogg, B. A., Peng, W., Gundersen, G. A., Benveniste, H., Vates, G. E., Deane, R., Goldman, S. A., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003748 · Cited by 5,824
Primary Progressive Aphasia
Weıntraub, S. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530120075013 · Cited by 3,018
Consortium to Establish a Registry for Alzheimer's Disease (CERAD)
Fillenbaum, G., & Heyman, A. (2002) · doi:10.1002/0470846410.ch42(iii · Cited by 2,859
Chronic traumatic encephalopathy in athletes: Progressive tauopathy after repetitive head injury
McKee, A. C., Cantu, R. C., Nowinski, C. J., Hedley-Whyte, E. T., Gavett, B. E., Budson, A. E., Santini, V. E., Lee, H.-S., Kubilus, C. A., & Stern, R. A. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181a9d503 · Cited by 2,295
Self-citation
The spectrum of disease in chronic traumatic encephalopathy
McKee, A. C., Stein, T. D., Nowinski, C. J., Stern, R. A., Daneshvar, D. H., Alvarez, V. E., Lee, H.-S., Hall, G., Wojtowicz, S. M., Baugh, C. M., et al. (2013) · Brain · doi:10.1093/brain/aws307 · Cited by 2,098
Self-citation
Editorial on Consensus Recommendations for the Postmortem Diagnosis of Alzheimer Disease from the National Institute on Aging and the Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer Disease
HYMAN, B. T., & TROJANOWSKI, J. Q. (1997) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199710000-00002 · Cited by 1,542
Propagation of Tau Pathology in a Model of Early Alzheimer's Disease
de Calignon, A., Polydoro, M., Suárez-Calvet, M., William, C., Adamowicz, D. H., Kopeikina, K. J., Pitstick, R., Sahara, N., Ashe, K. H., Carlson, G. A., et al. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.033 · Cited by 1,427
Propagation of Tau Misfolding from the Outside to the Inside of a Cell
Frost, B., Jacks, R. L., & Diamond, M. I. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808759200 · Cited by 1,252
Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration
Cairns, N. J., Bigio, E. H., Mackenzie, I. R. A., Neumann, M., Lee, V. M.-Y., Hatanpaa, K. J., White, C. L., Schneider, J. A., Grinberg, L. T., Halliday, G., et al. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0237-2 · Cited by 1,110
Trans-Synaptic Spread of Tau Pathology In Vivo
Liu, L., Drouet, V., Wu, J., Witter, M. P., Small, S. A., Clelland, C. L. T., & Duff, K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031302 · Cited by 994
Chronic Traumatic Encephalopathy in Blast-Exposed Military Veterans and a Blast Neurotrauma Mouse Model
Goldstein, L. E., Fisher, A. M., Tagge, C. A., Zhang, X.-L., Velisek, L., Sullivan, J. A., Upreti, C., Kracht, J. M., Ericsson, M., Wojnarowicz, M. W., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003716 · Cited by 958
Self-citation
Chronic Traumatic Encephalopathy in a National Football League Player
Omalu, B. I., DeKosky, S. T., Minster, R. L., Kamboh, M. I., Hamilton, R. L., & Wecht, C. H. (2005) · Neurosurgery · doi:10.1227/01.neu.0000163407.92769.ed · Cited by 894
The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy
the TBI/CTE group, McKee, A. C., Cairns, N. J., Dickson, D. W., Folkerth, R. D., Dirk Keene, C., Litvan, I., Perl, D. P., Stein, T. D., Vonsattel, J.-P., et al. (2016) · Acta Neuropathologica · doi:10.1007/s00401-015-1515-z · Cited by 885
Self-citation
The aftermath of boxing
Corsellis, J. A. N., Bruton, C. J., & Freeman-Browne, D. (1973) · Psychological Medicine · doi:10.1017/s0033291700049588 · Cited by 836
Does age play a role in recovery from sports-related concussion? A comparison of high school and collegiate athletes
Field, M., Collins, M. W., Lovell, M. R., & Maroon, J. (2003) · The Journal of Pediatrics · doi:10.1067/mpd.2003.190 · Cited by 802
Punch drunk
MARTLAND, H. S. (1928) · Journal of the American Medical Association · doi:10.1001/jama.1928.02700150029009 · Cited by 774
CHRONIC TRAUMATIC ENCEPHALOPATHY IN A NATIONAL FOOTBALL LEAGUE PLAYER: PART II
Omalu, B. I., DeKosky, S. T., Hamilton, R. L., Minster, R. L., Kamboh, M. I., Shakir, A. M., & Wecht, C. H. (2006) · Neurosurgery · doi:10.1227/01.neu.0000245601.69451.27 · Cited by 694
Chronic Traumatic Encephalopathy in a National Football League Player
Kelly, D. F. (2006) · Neurosurgery · doi:10.1097/00006123-200605000-00037 · Cited by 694
Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F18]-T808
Chien, D. T., Szardenings, A. K., Bahri, S., Walsh, J. C., Mu, F., Xia, C. A., Shankle, W. R., Lerner, A. J., Su, M., Elizarov, A. M., et al. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130098 · Cited by 683
TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy
McKee, A. C., Gavett, B. E., Stern, R. A., Nowinski, C. J., Cantu, R. C., Kowall, N. W., Perl, D. P., Hedley-Whyte, E. T., Price, B., Sullivan, C., et al. (2010) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181ee7d85 · Cited by 659
Self-citation
Early clinical PET imaging results with the novel PHF-tau radioligand [F-18]-T807
Chien, D. T., Bahri, S., Szardenings, A. K., Walsh, J. C., Mu, F., Su, M.-Y., Shankle, W. R., Elizarov, A., & Kolb, H. C. (2013) · Journal of Alzheimer's Disease · doi:10.3233/jad-122059 · Cited by 651 · cited 2×
“P-tau-specific PET ligands, such as T-807 and T-808 reported by Chien et al (13) might prove to identify primary tauopathy, such as CTE, and p-tau PET imaging combined with PET imaging for Aß might be useful to differentiate between CTE and AD (3, 44, 67).”
Background
Functionally-Detected Cognitive Impairment in High School Football Players without Clinically-Diagnosed Concussion
Talavage, T., Nauman, E., Breedlove, E., Yoruk, U., Dye, A. E., Morigaki, K. E., Feuer, H., & Leverenz, L. (2014) · Journal of Neurotrauma · doi:10.1089/neu.2010.1512 · Cited by 638
Neurodegenerative causes of death among retired National Football League players
Lehman, E. J., Hein, M. J., Baron, S. L., & Gersic, C. M. (2012) · Neurology · doi:10.1212/wnl.0b013e31826daf50 · Cited by 638
Seeding of Normal Tau by Pathological Tau Conformers Drives Pathogenesis of Alzheimer-like Tangles
Guo, J. L., & Lee, V. M.-Y. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.209296 · Cited by 636
Glucocorticoids increase amyloid-β and tau pathology in a mouse model of alzheimer’s disease
Green, K. N., Billings, L. M., Roozendaal, B., McGaugh, J. L., & LaFerla, F. M. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2797-06.2006 · Cited by 623
CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease
Buerger, K., Ewers, M., Pirttila, T., Zinkowski, R., Alafuzoff, I., Teipel, S. J., DeBernardis, J., Kerkman, D., McCulloch, C., Soininen, H., et al. (2006) · Brain · doi:10.1093/brain/awl269 · Cited by 586
A Mechanistic Analysis of Nondisruptive Axonal Injury: A Review
Maxwell, W. L., Povlishock, J. T., & Graham, D. I. (1997) · Journal of Neurotrauma · doi:10.1089/neu.1997.14.419 · Cited by 564
TDP-43 in Familial and Sporadic Frontotemporal Lobar Degeneration with Ubiquitin Inclusions
Cairns, N. J., Neumann, M., Bigio, E. H., Holm, I. E., Troost, D., Hatanpaa, K. J., Foong, C., White, C. L., Schneider, J. A., Kretzschmar, H. A., et al. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.070182 · Cited by 545
Aging-related tau astrogliopathy (ARTAG): Harmonized evaluation strategy
Kovacs, G. G., Ferrer, I., Grinberg, L. T., Alafuzoff, I., Attems, J., Budka, H., Cairns, N. J., Crary, J. F., Duyckaerts, C., Ghetti, B., et al. (2016) · Acta Neuropathologica · doi:10.1007/s00401-015-1509-x · Cited by 532
Self-citation
The role of cerebral ischemia in Alzheimer’s disease
Kalaria, R. N. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00125-1 · Cited by 526
The occult aftermath of boxing.
Roberts, G. W., Allsop, D., & Bruton, C. (1990) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.53.5.373 · Cited by 518
Microscopic lesions in the brain following head injury.
Oppenheimer, D. R. (1968) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.31.4.299 · Cited by 501
Axonal damage: a key predictor of outcome in human CNS diseases
Medana, I. M., & Esiri, M. M. (2003) · Brain · doi:10.1093/brain/awg061 · Cited by 465
Stalning af amyloid percursor protein to study axonal damage in mild head Injury
Blumbergs, P. C., Scott, G., Manavis, J., Wainwright, H., Simpson, D. A., & McLean, A. J. (1994) · The Lancet · doi:10.1016/s0140-6736(94)91712-4 · Cited by 454
Association of Traumatic Brain Injury With Late-Life Neurodegenerative Conditions and Neuropathologic Findings
Crane, P. K., Gibbons, L. E., Dams-O’Connor, K., Trittschuh, E. H., Leverenz, J. B., Keene, C. D., Sonnen, J. A., Montine, T. J., Bennett, D. A., Leurgans, S. E., et al. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2016.1948 · Cited by 454
Identification of Neuronal RNA Targets of TDP-43-containing Ribonucleoprotein Complexes
Sephton, C. F., Cenik, C., Küçükural, A., Dammer, E. B., Cenik, B., Han, Y., Dewey, C. M., Roth, F. P., Herz, J., Peng, J., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.190884 · Cited by 448
Association of traumatic brain injury with subsequent neurological and psychiatric disease: A meta-analysis
Perry, D. C., Sturm, V. E., Peterson, M. J., Pieper, C. F., Bullock, T., Boeve, B. F., Miller, B. L., Guskiewicz, K. M., Berger, M. S., Kramer, J. H., et al. (2016) · Journal of Neurosurgery · doi:10.3171/2015.2.jns14503 · Cited by 440
Pathological correlates of dementia in a longitudinal, population‐based sample of aging
Sonnen, J. A., Larson, E. B., Crane, P. K., Haneuse, S., Li, G., Schellenberg, G. D., Craft, S., Leverenz, J. B., & Montine, T. J. (2007) · Annals of Neurology · doi:10.1002/ana.21208 · Cited by 432
MEASUREMENT OF HEAD IMPACTS IN COLLEGIATE FOOTBALL PLAYERS: RELATIONSHIP BETWEEN HEAD IMPACT BIOMECHANICS AND ACUTE CLINICAL OUTCOME AFTER CONCUSSION
Guskiewicz, K. M., Mihalik, J. P., Shankar, V., Marshall, S. W., Crowell, D. H., Oliaro, S. M., Ciocca, M. F., & Hooker, D. N. (2007) · Neurosurgery · doi:10.1227/01.neu.0000306103.68635.1a · Cited by 423
Military-related traumatic brain injury and neurodegeneration
McKee, A. C., & Robinson, M. E. (2014) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2014.04.003 · Cited by 423
Self-citation
The neuropathology of sport
McKee, A. C., Daneshvar, D. H., Alvarez, V. E., & Stein, T. D. (2014) · Acta Neuropathologica · doi:10.1007/s00401-013-1230-6 · Cited by 422
Self-citation
The neurophysiology of brain injury
Gaetz, M. (2003) · Clinical Neurophysiology · doi:10.1016/s1388-2457(03)00258-x · Cited by 395
Clinical subtypes of chronic traumatic encephalopathy: Literature review and proposed research diagnostic criteria for traumatic encephalopathy syndrome
Montenigro, P. H., Baugh, C. M., Daneshvar, D. H., Mez, J., Budson, A. E., Au, R., Katz, D. I., Cantu, R. C., & Stern, R. A. (2014) · Alzheimer's Research & Therapy · doi:10.1186/s13195-014-0068-z · Cited by 375
Inducible Expression of Tau Repeat Domain in Cell Models of Tauopathy
Khlistunova, I., Biernat, J., Wang, Y., Pickhardt, M., von Bergen�, M., Gažová, Z., Mandelkow�, E., & Mandelkow, E. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507753200 · Cited by 366
Regulated protein aggregation: stress granules and neurodegeneration
Wolozin, B. L. (2012) · Molecular Neurodegeneration · doi:10.1186/1750-1326-7-56 · Cited by 350
The clinical spectrum of sport-related traumatic brain injury
Jordan, B. D. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.33 · Cited by 347
Chronic neuropathological and neurobehavioral changes in a repetitive mild traumatic brain injury model
Mouzon, B., Bachmeier, C. J., Ferro, A., Ojo, J., Crynen, G. C., Acker, C. M., Davies, P., MULLAN, M. J., Stewart, W. B., Jr., & Crawford, F. (2013) · Annals of Neurology · doi:10.1002/ana.24064 · Cited by 341
Chronic traumatic encephalopathy pathology in a neurodegenerative disorders brain bank
Bieniek, K. F., Ross, O. A., Cormier, K. A., Walton, R. L., Soto-Ortolaza, A., Johnston, A. E., DeSaro, P., Boylan, K. B., Graff-Radford, N. R., Wszolek, Z. K., et al. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1502-4 · Cited by 323
Self-citation
Neuronal cytoskeletal changes are an early consequence of repetitive head injury
Geddes, J. F., Vowles, G. H., Nicoll, J. A. R., & Révész, T. (1999) · Acta Neuropathologica · doi:10.1007/s004010051066 · Cited by 323
MEASUREMENT OF HEAD IMPACTS IN COLLEGIATE FOOTBALL PLAYERS
Mihalik, J. P., Bell, D. R., Marshall, S. W., & Guskiewicz, K. M. (2007) · Neurosurgery · doi:10.1227/01.neu.0000306101.83882.c8 · Cited by 314
Microglial neuroinflammation contributes to tau accumulation in chronic traumatic encephalopathy
Cherry, J. D., Tripodis, Y., Alvarez, V. E., Huber, B. R., Kiernan, P. T., Daneshvar, D. H., Mez, J., Montenigro, P. H., Solomon, T. M., Alosco, M. L., et al. (2016) · Acta Neuropathologica Communications · doi:10.1186/s40478-016-0382-8 · Cited by 304
Self-citation
Persistent, Long-term Cerebral White Matter Changes after Sports-Related Repetitive Head Impacts
Bazarian, J. J., Zhu, T., Zhong, J., Janigro, D., Rozen, E., Roberts, A., Javien, H., Merchant‐Borna, K., Abar, B. W., & Blackman, E. G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094734 · Cited by 300
Consequences of Repeated Blood-Brain Barrier Disruption in Football Players
Marchi, N., Bazarian, J. J., Puvenna, V., Janigro, M., Ghosh, C., Zhong, J., Zhu, T., Blackman, E. G., Stewart, D., Ellis, J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056805 · Cited by 296
Beta-amyloid deposition in chronic traumatic encephalopathy
Stein, T. D., Montenigro, P. H., Alvarez, V. E., Xia, W., Crary, J. F., Tripodis, Y., Daneshvar, D. H., Mez, J., Solomon, T., Meng, G., et al. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1435-y · Cited by 291
Self-citation
Application of the National Institute on Aging (NIA)-Reagan Institute Criteria for the Neuropathological Diagnosis of Alzheimer Disease
Newell, K. L., Hyman, B. T., Growdon, J. H., & Hedley-Whyte, E. T. (1999) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199911000-00004 · Cited by 289
Traumatic brain injury in later life increases risk for P arkinson disease
Gardner, R. C., Burke, J. F., Nettiksimmons, J., Goldman, S. M., Tanner, C. M., & Yaffe, K. S. (2015) · Annals of Neurology · doi:10.1002/ana.24396 · Cited by 287
Head injury and risk of Parkinson disease: A systematic review and meta‐analysis
Jafari, S., Etminan, M., Aminzadeh, F., & Samii, A. (2013) · Movement Disorders · doi:10.1002/mds.25458 · Cited by 282
Chronic traumatic encephalopathy: a spectrum of neuropathological changes following repetitive brain trauma in athletes and military personnel
Stein, T. D., Alvarez, V. E., & McKee, A. C. (2014) · Alzheimer s Research & Therapy · doi:10.1186/alzrt234 · Cited by 280
Self-citation
Blood-Brain Barrier Disruption Is an Early Event That May Persist for Many Years After Traumatic Brain Injury in Humans
Hay, J. R., Johnson, V. E., Young, A. M. H., Smith, D. H., & Stewart, W. B., Jr. (2015) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000261 · Cited by 275
Pathogenic Forms of Tau Inhibit Kinesin-Dependent Axonal Transport through a Mechanism Involving Activation of Axonal Phosphotransferases
Kanaan, N. M., Morfini, G. A., LaPointe, N. E., Pigino, G. F., Patterson, K. R., Song, Y., Andreadis, A., Fu, Y., Brady, S. T., & Binder, L. I. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0560-11.2011 · Cited by 273
Stress Acts Cumulatively To Precipitate Alzheimer's Disease-Like Tau Pathology and Cognitive Deficits
Sotiropoulos, I., Catania, C., Pinto, L., Silva, R., Pollerberg, G. E., Takashima, A., Sousa, N., & Almeida, O. F. X. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0730-11.2011 · Cited by 263
The Generation of a 17 kDa Neurotoxic Fragment: An Alternative Mechanism by which Tau Mediates β-Amyloid-Induced Neurodegeneration
Park, S.-Y., & Ferreira, A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1125-05.2005 · Cited by 262
Accumulation of Amyloid β and Tau and the Formation of Neurofilament Inclusions Following Diffuse Brain Injury in the Pig
Smith, D. H., Chen, X.-H., Nonaka, M., Trojanowski, J. Q., Lee, V.-Y., Saatman, K. E., Leoni, M. J., Xu, B.-N., Wolf, J. A., & Meaney, D. F. (1999) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199909000-00008 · Cited by 260
Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo
Žilka, N., Filipčík, P., Koson, P., Fialová, Ľ., Škrabana, R., Žilková, M., Rolkova, G., Kontseková, E., & Novák, M. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.05.029 · Cited by 254
Clinicopathologic assessment and imaging of tauopathies in neurodegenerative dementias
Murray, M. E., Kouri, N., Lin, W.-L., Jack, C. R., Dickson, D. W., & Vemuri, P. (2014) · Alzheimer s Research & Therapy · doi:10.1186/alzrt231 · Cited by 249
White Matter Integrity in the Brains of Professional Soccer Players Without a Symptomatic Concussion
Koerte, I. K., Ertl-Wagner, B. B., Reiser, M. F., ZAFONTE, R. D., & Shenton, M. E. (2012) · JAMA · doi:10.1001/jama.2012.13735 · Cited by 245
Peripheral markers of blood–brain barrier damage
Marchi, N., Cavaglià, M., Fazio, V. J., Bhudia, S. K., Hallene, K. L., & Janigro, D. (2004) · Clinica Chimica Acta · doi:10.1016/j.cccn.2003.12.008 · Cited by 245
NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation
Amadoro, G., Ciotti, M. T., Costanzi, M., Cestari, V., Calissano, P., & Canu, N. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511065103 · Cited by 243
Pathobiology of traumatically induced axonal injury in animals and man
Povlishock, J. T. (1993) · Annals of Emergency Medicine · doi:10.1016/s0196-0644(05)82738-6 · Cited by 236 · cited 1×
“around blood vessels or at the gray-white matter interface) (16, 26, 80).”
Background
The Development of Amyloid β Protein Deposits in the Aged Brain
Thal, D. R., Capetillo-Zarate, E., Del Tredici, K., & Braak, H. (2006) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2006.6.re1 · Cited by 234
Tau isoform profile and phosphorylation state in dementia pugilistica recapitulate Alzheimer's disease
Schmidt, M., Zhukareva, V., Newell, K., Lee, V., & Trojanowski, J. (2001) · Acta Neuropathologica · doi:10.1007/s004010000330 · Cited by 230
Chronic traumatic encephalopathy in an Iraqi war veteran with posttraumatic stress disorder who committed suicide
Omalu, B. I., Hammers, J., Bailes, J. E., Hamilton, R. L., Kamboh, M. I., Webster, G., & Fitzsimmons, R. P. (2011) · Neurosurgical FOCUS · doi:10.3171/2011.9.focus11178 · Cited by 229
Differential distribution of neurofibrillary tangles in the cerebral cortex of dementia pugilistica and Alzheimer's disease cases
Hof, P. R., Bouras, C., Bu�e, L., Delacourte, A., Perl, D. P., & Morrison, J. H. (1992) · Acta Neuropathologica · doi:10.1007/bf00304630 · Cited by 213
Divergent patterns of cytosolic TDP-43 and neuronal progranulin expression following axotomy: Implications for TDP-43 in the physiological response to neuronal injury
Moisse, K., Volkening, K., Leystra-Lantz, C., Welch, I., Hill, T., & Strong, M. J. (2009) · Brain Research · doi:10.1016/j.brainres.2008.10.021 · Cited by 210
Re-examination of ex-boxers' brains using immunohistochemistry with antibodies to amyloid ?-protein and tau protein
Tokuda, T., Ikeda, S., Yanagisawa, N., Ihara, Y., & Glenner, G. G. (1991) · Acta Neuropathologica · doi:10.1007/bf00308813 · Cited by 202
Tau prions from Alzheimer’s disease and chronic traumatic encephalopathy patients propagate in cultured cells
Woerman, A. L., Aoyagi, A., Patel, S. S., Kazmi, S. A., Lobach, I. V., Grinberg, L. T., McKee, A. C., Seeley, W. W., Olson, S. H., & Prusiner, S. B. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1616344113 · Cited by 180
Self-citation
Parkinson's disease and its comorbid disorders
Gorell, J. M., Johnson, C. C., & Rybicki, B. A. (1994) · Neurology · doi:10.1212/wnl.44.10.1865 · Cited by 176
Dementia pugilistica mit anatomischem Befund
Brandenburg, W., & Hallervorden, J. (1954) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf00955101 · Cited by 164
Invited review: Prion‐like transmission and spreading of tau pathology
Clavaguera, F., Hench, J., Goedert, M., & Tolnay, M. (2015) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12197 · Cited by 156
Predisposition to accelerated Alzheimer-related changes in the brains of human immunodeficiency virus negative opiate abusers
Anthony, I. C., Norrby, K. E., Dingwall, T., Carnie, F. W., Millar, T., Arango, J. C., Robertson, R., & Bell, J. E. (2010) · Brain · doi:10.1093/brain/awq263 · Cited by 156
Chronic traumatic encephalopathy in a professional American wrestler
Omalu, B. I., Fitzsimmons, R. P., Hammers, J., & Bailes, J. (2010) · Journal of Forensic Nursing · doi:10.1111/j.1939-3938.2010.01078.x · Cited by 155
Neuropathological observations in a case of autism presenting with self-injury behavior
Hof, P. R., Knabe, R., Bovier, P., & Bouras, C. (1991) · Acta Neuropathologica · doi:10.1007/bf00308819 · Cited by 151
Biomechanics of Traumatic Brain Injury: Influences of the Morphologic Heterogeneities of the Cerebral Cortex
Cloots, R. J. H., Gervaise, H. M. T., van Dommelen, J. A. W., & Geers, M. G. D. (2008) · Annals of Biomedical Engineering · doi:10.1007/s10439-008-9510-3 · Cited by 151
Absence of chronic traumatic encephalopathy in retired football players with multiple concussions and neurological symptomatology
Hazrati, L.-N., Tartaglia, M. C., Diamandis, P., Davis, K. D., Green, R. E., Wennberg, R., Wong, J. C., Ezerins, L., & Tator, C. H. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00222 · Cited by 146
Metabolic imaging of mild traumatic brain injury
Lin, A., Liao, H.-J., Merugumala, S. K., Prabhu, S., Meehan, W. P. I., & Ross, B. (2012) · Brain Imaging and Behavior · doi:10.1007/s11682-012-9181-4 · Cited by 145
Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau
Van der Jeugd, A., Hochgräfe, K., Ahmed, T., Decker, J. M., Sydow, A., Hofmann, A., Wu, D., Messing, L., Balschun, D., D’Hooge, R., et al. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-0987-3 · Cited by 135
Experience-dependent behavioral plasticity is disturbed following traumatic injury to the immature brain
Giza, C. C., Griesbach, G. S., & Hovda, D. A. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.06.003 · Cited by 135 · cited 1×
“Studies have suggested that children and adolescents experience prolonged recovery rates after TBI compared with adults (24) as well as poorer outcomes (29).”
Background
Traumatic brain injury, paraquat exposure, and their relationship to Parkinson disease
Lee, P., Bordelon, Y. M., Bronstein, J. M., & Ritz, B. R. (2012) · Neurology · doi:10.1212/wnl.0b013e3182749f28 · Cited by 134
Traumatic Encephalopathy (`Punch Drunk') of Professional Pugilists
Parker, H. L. (1934) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.s1-15.57.20 · Cited by 127
Dementia in a punch-drunk wife
Roberts, G. W., Whitwell, H., Acland, P. R., & Bruton, C. J. (1990) · The Lancet · doi:10.1016/0140-6736(90)90520-f · Cited by 126
Tauopathy PET and amyloid PET in the diagnosis of chronic traumatic encephalopathies: studies of a retired NFL player and of a man with FTD and a severe head injury
Mitsis, E. M., Riggio, S., Kostakoğlu, L., Dickstein, D. L., Macháč, J., Delman, B. N., Goldstein, M., Jennings, D. L., D’Antonio, E., Martin, J. B., et al. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.91 · Cited by 124
The Physiological Link between Metabolic Rate Depression and Tau Phosphorylation in Mammalian Hibernation
Stieler, J., Bullmann, T., Kohl, F., Tøien, Ø., Brückner, M. K., Härtig, W., Barnes, B. M., & Arendt, T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014530 · Cited by 123
Abnormal TDP-43 expression is identified in the neocortex in cases of dementia pugilistica, but is mainly confined to the limbic system when identified in high and moderate stages of Alzheimer's disease
King, A., Sweeney, F., Bódi, I., Troakes, C., Maekawa, S., & Al‐Sarraj, S. (2010) · Neuropathology · doi:10.1111/j.1440-1789.2009.01085.x · Cited by 121
Neurofibrillary tangles, but not Alzheimer‐type pathology, in a young boxer
Geddes, J. F., Vowles, G. H., Robinson, S. F. D., & Sutcliffe, J. C. (1996) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1996.tb00840.x · Cited by 116
Micromechanics of diffuse axonal injury: influence of axonal orientation and anisotropy
Cloots, R. R., van Dommelen, J. V., Nyberg, T., Kleiven, S., & Geers, M. (2011) · Biomechanics and Modeling in Mechanobiology · doi:10.1007/s10237-010-0243-5 · Cited by 112
Characterization of Early Pathological Tau Conformations and Phosphorylation in Chronic Traumatic Encephalopathy
Kanaan, N. M., Cox, K. K., Alvarez, V. E., Stein, T. D., Poncil, S., & McKee, A. C. (2015) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlv001 · Cited by 110
Self-citation
Review: Contact sport-related chronic traumatic encephalopathy in the elderly: clinical expression and structural substrates
Costanza, A., Weber, K., Gandy, S., Bouras, C., Hof, P. R., Giannakopoulos, P., & Canuto, A. (2011) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2011.01186.x · Cited by 109
Interneuronal Transfer of Human Tau Between Lamprey Central Neurons in situ
Kim, W., Lee, S., Jung, C., Ahmed, A., Lee, G. S., & Hall, G. F. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1273 · Cited by 107
Conceptual Evolution in Alzheimer's Disease: Implications for Understanding the Clinical Phenotype of Progressive Neurodegenerative Disease
Jicha, G. A., & Carr, S. A. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1237 · Cited by 107
Histological evidence of chronic traumatic encephalopathy in a large series of neurodegenerative diseases
Ling, H., Holton, J. L., Shaw, K., Davey, K., Lashley, T., & Revesz, T. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1496-y · Cited by 106
Stress‐induced hyperphosphorylation of tau in the mouse brain
Okawa, Y., Ishiguro, K., & Fujita, S. C. (2003) · FEBS Letters · doi:10.1016/s0014-5793(02)03883-8 · Cited by 98
Glucocorticoids Trigger Alzheimer disease-like pathobiochemistry in rat neuronal cells expressing human tau
Sotiropoulos, I., Catania, C., Riedemann, T., Fry, J. P., Breen, K. C., Michaelidis, T. M., & Almeida, O. F. X. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05613.x · Cited by 97
Beitrag zur Kenntnis der chronischen cerebralen Krankheitsbilder bei Boxern
Grahmann, H., & Ule, G. (2008) · Psychiatria et Neurologia · doi:10.1159/000138743 · Cited by 95
Current understanding of chronic traumatic encephalopathy
Baugh, C. M., Robbins, C. A., Stern, R. A., & McKee, A. C. (2014) · Current Treatment Options in Neurology · doi:10.1007/s11940-014-0306-5 · Cited by 94
Self-citation
Cytosolic TDP-43 expression following axotomy is associated with caspase 3 activation in NFL−/− mice: Support for a role for TDP-43 in the physiological response to neuronal injury
Moisse, K., Mepham, J., Volkening, K., Welch, I., Hill, T., & Strong, M. J. (2009) · Brain Research · doi:10.1016/j.brainres.2009.07.023 · Cited by 93
TDP-43 in central nervous system development and function: clues to TDP-43-associated neurodegeneration
Sephton, C. F., Cenik, B., Cenik, B. K., Herz, J., & Yu, G. (2012) · bchm · doi:10.1515/hsz-2012-0115 · Cited by 86
Clinical Features of Repetitive Traumatic Brain Injury and Chronic Traumatic Encephalopathy
Montenigro, P. H., Bernick, C. B., & Cantu, R. C. (2015) · Brain Pathology · doi:10.1111/bpa.12250 · Cited by 81
Blast exposure causes dynamic microglial/macrophage responses and microdomains of brain microvessel dysfunction
Huber, B. R., Meabon, J. S., Hoffer, Z. S., Zhang, J., Hoekstra, J. G., Pagulayan, K. F., McMillan, P. J., Mayer, C. L., Banks, W. A., Kraemer, B. C., et al. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.01.022 · Cited by 78
Cross Currents in Protein Misfolding Disorders: Interactions and Therapy
Morales, R., Green, K., & Soto, C. (2009) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152709789541998 · Cited by 72
Cerebral atrophy associated with boxing
NEUBUERGER, K. T. (1959) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1959.02340160001001 · Cited by 66
Treatment of Functional Motor Disorders
Gelauff, J., Dreissen, Y. E. M., Tijssen, M. A. J., & Stone, J. (2014) · Current Treatment Options in Neurology · doi:10.1007/s11940-014-0286-5 · Cited by 66
Axonal ligation induces transient redistribution of TDP-43 in brainstem motor neurons
Sato, T., Takeuchi, S., Saito, A., Ding, W., Bamba, H., Matsuura, H., Hisa, Y., Tooyama, I., & Urushitani, M. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.09.050 · Cited by 63
Establishing a Clinically Relevant Large Animal Model Platform for TBI Therapy Development: Using C yclosporin A as a Case Study
Margulies, S. S., Kilbaugh, T. J., Sullivan, S., Smith, C., PROPERT, K. J., Byro, M., Saliga, K., Costine, B. A., & Duhaime, A. (2015) · Brain Pathology · doi:10.1111/bpa.12247 · Cited by 59
[Diagnosis of chronic cerebral symptoms in boxers (dementia pugilistica & traumatic encephalopathy of boxers)].
Grahmann, H., & Ule, G. (2000) · PubMed · Cited by 58
Medical Aspects of Boxing
Jordan, B. D. (1992) · Medical Entomology and Zoology · Cited by 57
Neurodegenerative and other chronic disorders among people aged 75 years and over in the community
Waite, L. M., Broe, G. A., Creasey, H. M., Grayson, D. A., Cullen, J. S., Edelbrock, D., Dobson, M., & O’Toole, B. I. (1997) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1997.tb126655.x · Cited by 54
Punch drunk. Its pathogenesis and pathology on the basis of a verified case.
Cb, C. (1962) · PubMed · Cited by 53
Is tau ready for admission to the prion club?
Hall, G. F., & Patuto, B. A. (2012) · Prion · doi:10.4161/pri.19912 · Cited by 43
The Frontotemporal Syndromes of ALS. Clinicopathological Correlates
Strong, M. J., & Yang, W. (2011) · Journal of Molecular Neuroscience · doi:10.1007/s12031-011-9609-0 · Cited by 41
Dementia pugilistica in an alcoholic achondroplastic dwarf
Williams, D. J., & Tannenberg, A. E. G. (1996) · Pathology · doi:10.1080/00313029600169653 · Cited by 40
Compression Alters Kinase and Phosphatase Activity and Tau and MAP2 Phosphorylation Transiently while Inducing the Fast Adaptive Dendritic Remodeling of Underlying Cortical Neurons
Chen, L.-J., Wang, Y., & Tseng, G. (2010) · Journal of Neurotrauma · doi:10.1089/neu.2010.1308 · Cited by 39
Progression of tau pathology within cholinergic nucleus basalis neurons in chronic traumatic encephalopathy: A chronic effects of neurotrauma consortium study
Mufson, E. J., Perez, S. E., Nadeem, M., Mahady, L. J., Kanaan, N. M., Abrahamson, E. E., Ikonomović, M. D., Crawford, F., Alvarez, V. E., Stein, T. D., et al. (2016) · Brain Injury · doi:10.1080/02699052.2016.1219058 · Cited by 31
Self-citation
[Generalized Alzheimer's neurofibrillary lesions without senile plaques. (Presentation of one anatomo-clinical case)].
Constantinidis, J., & Tissot, R. (1967) · PubMed · Cited by 24
PROTECTING THE BOXER
McCown, I. A. (1959) · JAMA · doi:10.1001/jama.1959.03000300005002 · Cited by 13
Pathology of the Superior Colliculus in Chronic Traumatic Encephalopathy
Armstrong, R. A., McKee, A. C., & Cairns, N. J. (2016) · Optometry and Vision Science · doi:10.1097/opx.0000000000000911 · Cited by 13
Self-citation
Poster Abstracts
Klitkou, J., Dahlrot, R. H., Hansen, S., & Kristensen, B. W. (2014) · Brain Pathology · doi:10.1111/bpa.12184 · Cited by 4
Introduction
Smith, C. (2015) · Brain Pathology · doi:10.1111/bpa.12251 · Cited by 2
Prion-Like Properties of Assembled Tau Protein
Clavaguera, F., Tolnay, M., & Goedert, M. (2013) · Research and perspectives in Alzheimer's disease · doi:10.1007/978-3-642-35491-5_7 · Cited by 1

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2 of the 132 references couldn’t be matched to a known paper.

Research works printed but not linked: 3

Critchley M, 1949, Hommage a Clovis Vincent
Jordan BD, 1993, Chronic neurologic injuries in boxing, Med Aspects Boxing, 1, 177
Millspaugh J, 1937, Dementia pugilistica, US Naval Med Bull, 35, 297Y303

Sorted by citations

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Brown, R. H., & Al‐Chalabi, A. (2017) · New England Journal of Medicine · doi:10.1056/nejmra1603471 · Cited by 2,580
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Authors: McKee, A. C., Stein, T. D., Kiernan, P. T., & Alvarez, V. E.
Affiliations: Boston University (US)
ORCID: McKee, Ann C.
Stein, Thor D.
Kiernan, Patrick T.
Venue: Brain Pathology
Publisher: Wiley
Published: 2015-04-23
Volume: 25
Issue: 3
Pages: 350-364
ISSN: 1015-6305 (ISSN-L)
1750-3639
DOI: 10.1111/bpa.12248
PMC: PMC4526170
OpenAlex: W1888623186
Cited by: 585
References: 132
Citations by year: 2026: 37 · 2025: 62 · 2024: 60 · 2023: 53 · 2022: 45 · 2021: 63 · 2020: 44 · 2019: 69 · 2018: 49 · 2017: 50 · 2016: 39 · 2015: 12
FWCI: 6.50
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Brain Pathology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Neurological Disorders and Stroke (1UO1NS086659-01)
Department of Defense
Department of Veterans Affairs
National Institute of Aging (P30AG13846)
NFL
NOCSAE
Sports Legacy Institute
WWE
Topics: Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords: chronic traumatic encephalopathy, repetitive head trauma, tauopathy, hyperphosphorylated tau, neurofibrillary tangles, amyloid-beta, sports-related brain injury, blast injury, neurodegeneration, genetic risk factors, neuropathology
MeSH terms: Neuropathology, Brain, DNA-Binding Proteins, Humans, tau Proteins, Brain Injury, Chronic

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The Neuropathology of Chronic Traumatic Encephalopathy

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