The DOI matches its Crossref record; 283 of the 283 references it cites were found in a registry or an index.
Stratification of astrocytes in healthy and diseased brain
Open accessAbstract
Astrocytes, a subtype of glial cells, come in variety of forms and functions. However, overarching role of these cell is in the homeostasis of the brain, be that regulation of ions, neurotransmitters, metabolism or neuronal synaptic networks. Loss of homeostasis represents the underlying cause of all brain disorders. Thus, astrocytes are likely involved in most if not all of the brain pathologies. We tabulate astroglial homeostatic functions along with pathological condition that arise from dysfunction of these glial cells. Classification of astrocytes is presented with the emphasis on evolutionary trails, morphological appearance and numerical preponderance. We note that, even though astrocytes from a variety of mammalian species share some common features, human astrocytes appear to be the largest and most complex of all astrocytes studied thus far. It is then an imperative to develop humanized models to study the role of astrocytes in brain pathologies, which is perhaps most abundantly clear in the case of glioblastoma multiforme.
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“Astrocytes may also exhibit cell-autonomous disturbances8, as happens in astrocytopathies resulting from mutated alleles of astrocytic genes (for example, GFAP in Alexander disease)9, as well as from direct viral infections or exposure to toxic substances that specifically damage astrocytes (for example, ammonium in hepatic encephalopathy)10.”
From Reactive astrocyte nomenclature, definitions, and future directions (2021) · cites this paper as [8]
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Metadata
- Authors
- Verkhratsky, A., Zorec, R., & Parpura, V.
- Affiliations
- Ikerbasque (ES)
- University of Ljubljana (SI)
- Civitan International (US)
- Venue
- Brain Pathology
- Publisher
- Wiley
- Published
- 2017-08-13
- Volume
- 27
- Issue
- 5
- Pages
- 629-644
- ISSN
- 1015-6305 (ISSN-L)
- 1750-3639
- PMC
- PMC5599174
- OpenAlex
- W2621558595
- Cited by
- 236
- References
- 283
- Citations by year
- 2026: 11 · 2025: 18 · 2024: 19 · 2023: 32 · 2022: 27 · 2021: 45 · 2020: 32 · 2019: 32 · 2018: 14 · 2017: 4
- FWCI
- 11.17
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain Pathology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Funders
- National Institutes of Health (HD078678)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Oncology › Glioma Diagnosis and Treatment
- Keywords
- astrocytes, astrocyte morphology, glioblastoma, brain disorders, glial dysfunction
- MeSH terms
- Animals, Astrocytes, Brain, Brain Diseases, Homeostasis, Humans, Neurons
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