Cited by 55Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology Research

Astroglial Calcium Signalling in Alzheimer's Disease

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Verkhratsky, Alexei, Rodríguez-Arellano, J.J., Parpura, Vladimir, Zorec, Robert·2017·Biochemical and Biophysical Research Communications

Abstract

Neuroglial contribution to Alzheimer's disease (AD) is pathologically relevant and highly heterogeneous. Reactive astrogliosis and activation of microglia contribute to neuroinflammation, whereas astroglial and oligodendroglial atrophy affect synaptic transmission and underlie the overall disruption of the central nervous system (CNS) connectome. Astroglial function is tightly integrated with the intracellular ionic signalling mediated by complex dynamics of cytosolic concentrations of free Ca 2+ and Na+. Astroglial ionic signalling is mediated by plasmalemmal ion channels, mainly associated with ionotropic receptors, pumps and solute carrier transporters, and by intracellular organelles comprised of the endoplasmic reticulum and mitochondria. The relative contribution of these molecular cascades/organelles can be plastically remodelled in development and under environmental stress. In AD astroglial Ca 2+ signalling undergoes substantial reorganisation due to an abnormal regulation of expression of Ca 2+ handling molecular cascades.

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  1. [63][63] A. Alzheimer, Beiträge zur Kenntnis der pathologischen Neuroglia und ihrer Beziehungen zu den Abbauvorgängen im Nervengewebe., in: F. Nissl, A. Alzheimer (Eds.) Histologische und histopathologische Arbeiten über die Grosshirnrinde mit besonderer Berücksichtigung der pathologischen Anatomie der Geisteskrankheiten., Gustav Fischer, Jena, 1910, pp. 401-562.
  2. [65][65] R. Virchow, Die Cellularpathologie in ihrer Begründung auf physiologische and pathologische Gewebelehre. Zwanzig Vorlesungen gehalten während der Monate Februar, März und April 1858 im pathologischen Institut zu Berlin., First edition ed., August Hirschwald, Berlin, 1858.

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Authors
Verkhratsky, A., Rodríguez-Arellano, J. J., Parpura, V., & Zorec, R.
Affiliations
  • Ikerbasque (ES)
  • Civitan International (US)
  • University of Ljubljana (SI)
Corresponding author
Verkhratsky, Alexei
Venue
Biochemical and Biophysical Research Communications
Publisher
Elsevier BV
Published
2017-02
Volume
483
Issue
4
Pages
1005-1012
ISSN
0006-291X (ISSN-L)
OpenAlex
W3025955412
Cited by
55
References
142
Citations by year
2026: 3 · 2025: 5 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 7 · 2020: 5 · 2019: 10 · 2018: 6 · 2017: 4
FWCI
0.78
Type
journal article
Language
en
Locations
  • Biochemical and Biophysical Research Communications (publishedVersion)
  • PubMed (publishedVersion)
  • Research Explorer (The University of Manchester) (publishedVersion, other-oa)
Funders
  • Ikerbasque, Basque Foundation for Science
  • Alzheimer's Research Trust
  • European Commission
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
Alzheimer's disease, reactive astrogliosis, neuroinflammation, microglia, synaptic transmission, ligand-gated ion channels, ion pumps, solute carrier transporters, endoplasmic reticulum, mitochondria, calcium handling
MeSH terms
Alzheimer Disease, Astrocytes, Homeostasis, Humans, Calcium Signaling

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