Astroglial Calcium Signalling in Alzheimer's Disease
Open accessAbstract
Neuroglial contribution to Alzheimer's disease (AD) is pathologically relevant and highly heterogeneous. Reactive astrogliosis and activation of microglia contribute to neuroinflammation, whereas astroglial and oligodendroglial atrophy affect synaptic transmission and underlie the overall disruption of the central nervous system (CNS) connectome. Astroglial function is tightly integrated with the intracellular ionic signalling mediated by complex dynamics of cytosolic concentrations of free Ca 2+ and Na+. Astroglial ionic signalling is mediated by plasmalemmal ion channels, mainly associated with ionotropic receptors, pumps and solute carrier transporters, and by intracellular organelles comprised of the endoplasmic reticulum and mitochondria. The relative contribution of these molecular cascades/organelles can be plastically remodelled in development and under environmental stress. In AD astroglial Ca 2+ signalling undergoes substantial reorganisation due to an abnormal regulation of expression of Ca 2+ handling molecular cascades.
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Aβ-induced dysregulation of ionic homeostasis in astroglial cells may crucially contribute to their pathological remodelling.
“In turn, the Aβ-induced dysregulation of ionic homeostasis in astroglial cells may crucially contribute to their pathological remodelling (Boscia et al., 2017; Verkhratsky et al., 2017; Piccialli et al., 2020).”
From Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes (2022) · cites this paper as Verkhratsky et al., 2017
Aβ exerts oxidative stress in astrocytes by altering astrocytic Ca2+ homeostasis and mitochondrial function.
“Moreover, Aβ has been recognized to exert oxidative stress in astrocytes by altering astrocytic Ca2+ homeostasis and mitochondrial function (Abramov et al., 2004; Verkhratsky et al., 2017; Piccialli et al., 2020).”
From Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes (2022) · cites this paper as Verkhratsky et al., 2017
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Self-citationLow levels of astroglial markers in Parkinson’s disease: relationship to α-synuclein accumulation
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Self-citationAstrocytes are a major target in thiamine deficiency and Wernicke's encephalopathy
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Aβ leads to Ca2+ signaling alterations and transcriptional changes in glial cells
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TRP Channels Coordinate Ion Signalling in Astroglia
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Self-citationThe multifaceted role of glial cells in amyotrophic lateral sclerosis
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The ancient roots of calcium signalling evolutionary tree
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Self-citationPresenilin‐2 dampens intracellular Ca2+ stores by increasing Ca2+ leakage and reducing Ca2+ uptake
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Differential deregulation of astrocytic calcium signalling by amyloid-β, TNFα, IL-1β and LPS.
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Store-operated calcium entry in neuroglia
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Self-citationLoss of astrocytic glutamate transporters in Wernicke encephalopathy
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Glial Calcium Signalling in Alzheimer’s Disease
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Self-citation
Flagged first, then by citations
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Cited by
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Stratification of astrocytes in healthy and diseased brain
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The Role of Oxygen Homeostasis and the HIF-1 Factor in the Development of Neurodegeneration
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- Authors
- Verkhratsky, A., Rodríguez-Arellano, J. J., Parpura, V., & Zorec, R.
- Affiliations
- Ikerbasque (ES)
- Civitan International (US)
- University of Ljubljana (SI)
- Corresponding author
- Verkhratsky, Alexei
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2017-02
- Volume
- 483
- Issue
- 4
- Pages
- 1005-1012
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W3025955412
- Cited by
- 55
- References
- 142
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 7 · 2020: 5 · 2019: 10 · 2018: 6 · 2017: 4
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion, other-oa)
- Funders
- Ikerbasque, Basque Foundation for Science
- Alzheimer's Research Trust
- European Commission
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- Alzheimer's disease, reactive astrogliosis, neuroinflammation, microglia, synaptic transmission, ligand-gated ion channels, ion pumps, solute carrier transporters, endoplasmic reticulum, mitochondria, calcium handling
- MeSH terms
- Alzheimer Disease, Astrocytes, Homeostasis, Humans, Calcium Signaling
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