Human amygdala involvement in Alzheimer's disease revealed by stereological and dia‐PASEF analysis
Open accessAbstract
Alzheimer's disease (AD) is characterized by the accumulation of pathological amyloid‐β (Aβ) and Tau proteins. According to the prion‐like hypothesis, both proteins can seed and disseminate through brain regions through neural connections and glial cells. The amygdaloid complex (AC) is involved early in the disease, and its widespread connections with other brain regions indicate that it is a hub for propagating pathology. To characterize changes in the AC as well as the involvement of neuronal and glial cells in AD, a combined stereological and proteomic analysis was performed in non‐Alzheimer's disease and AD human samples. The synaptic alterations identified by proteomic data analysis could be related to the volume reduction observed in AD by the Cavalieri probe without neuronal loss. The pathological markers appeared in a gradient pattern with the medial region (cortical nucleus, Co) being more affected than lateral regions, suggesting the relevance of connections in the distribution of the pathology among different brain regions. Generalized astrogliosis was observed in every AC nucleus, likely related to deposits of pathological proteins. Astrocytes might mediate phagocytic microglial activation, whereas microglia might play a dual role since protective and toxic phenotypes have been described. These results highlight the potential participation of the amygdala in the disease spreading from/to olfactory areas, the temporal lobe and beyond. Proteomic data are available via ProteomeXchange with identifier PXD038322.
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Among the most upregulated DEGs, higher amounts of MMP3, IBSP, or TAGLN in the brain have been linked to increased risk of AD.
“Among the most upregulated DEGs, higher amounts of MMP3 (52), IBSP (53), or TAGLN (54) in the brain have been linked to increased risk of AD.”
From Modeling late-onset Alzheimer’s disease neuropathology via direct neuronal reprogramming (2024) · cites this paper as [54]
Table 2 in the Results lists TAGLN (transgelin) as an upregulated protein in AD amygdala samples, with a fold change of 1.82. The paper reports differential protein expression, not TAGLN as an upregulated DEG, and does not establish that higher TAGLN increases the risk of developing AD. Citation (54) is attached to TAGLN, so the MMP3 and IBSP claims are not assessed here. (LLM, conf=0.87)
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Cites
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works
Metascape provides a biologist-oriented resource for the analysis of systems-level datasets
Zhou, Y., Zhou, B., Pache, L., Chang, M., Khodabakhshi, A. H., Tanaseichuk, O., Benner, C., & Chanda, S. K. (2019) · Nature Communications · doi:10.1038/s41467-019-09234-6 · Cited by 14,611 · see citing works
The PRIDE database resources in 2022: a hub for mass spectrometry-based proteomics evidences
Perez-Riverol, Y., Bai, J., Bandla, C., García-Seisdedos, D., Hewapathirana, S., Kamatchinathan, S., Kundu, D. J., Prakash, A., Frericks-Zipper, A., Eisenacher, M., et al. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkab1038 · Cited by 6,125 · see citing works
BioGRID: a general repository for interaction datasets
Stark, C. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkj109 · Cited by 3,960 · see citing works
Phases of Aβ-deposition in the human brain and its relevance for the development of AD
Thal, D. R., Rüb, U., Orantes, M., & Braak, H. (2002) · Neurology · doi:10.1212/wnl.58.12.1791 · Cited by 3,490 · see citing works
Braak, H., Alafuzoff, I., Arzberger, T., Kretzschmar, H., & Del Tredici, K. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0127-z · Cited by 3,172 · see citing works
Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report
Nelson, P. T., Dickson, D. W., Trojanowski, J. Q., Jack, C. R., Boyle, P. A., Arfanakis, K., Rademakers, R., Alafuzoff, I., Attems, J., Brayne, C., et al. (2019) · Brain · doi:10.1093/brain/awz099 · Cited by 1,547 · see citing works
Neuron numbers and dendritic extent in normal aging and Alzheimer’s disease
Coleman, P. D., & Flood, D. G. (1987) · Neurobiology of Aging · doi:10.1016/0197-4580(87)90127-8 · Cited by 772 · see citing works
Protein transmission in neurodegenerative disease
Peng, C., Trojanowski, J. Q., & Lee, V. M.-Y. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-020-0333-7 · Cited by 625 · see citing works
Understanding Emotions: Origins and Roles of the Amygdala
Šimić, G., Tkalčić, M., Vukić, V., Mulc, D., Španić, E., Šagud, M., Olucha-Bordonau, F. E., Vukšić, M., & Hof, P. R. (2021) · Biomolecules · doi:10.3390/biom11060823 · Cited by 556 · see citing works
The preclinical phase of the pathological process underlying sporadic Alzheimer’s disease
Braak, H., & Del Tredici, K. (2015) · Brain · doi:10.1093/brain/awv236 · Cited by 540 · see citing works
Microglia and Astrocytes in Alzheimer's Disease: Implications for Therapy
Fakhoury, M. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170720095240 · Cited by 482 · see citing works
Seyfried, N. T., Dammer, E. B., Swarup, V., Nandakumar, D., Duong, D. M., Yin, L., Deng, Q., Nguyen, T., Hales, C. M., Wingo, T., et al. (2017) · Cell Systems · doi:10.1016/j.cels.2016.11.006 · Cited by 477 · see citing works
Amygdala atrophy is prominent in early Alzheimer's disease and relates to symptom severity
Poulin, S. P., Dautoff, R. J., Morris, J. C., Barrett, L. F., & Dickerson, B. C. (2011) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2011.06.014 · Cited by 451 · see citing works
Episodic memory in normal aging and Alzheimer disease: Insights from imaging and behavioral studies
Tromp, D., Dufour, A., Lithfous, S., Pebayle, T., & Després, O. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.08.006 · Cited by 390 · see citing works
TDP-43 Pathology in Alzheimer’s Disease
Meneses, A. D., Koga, S., O’Leary, J., Dickson, D. W., Bu, G., & Zhao, N. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00503-x · Cited by 360 · see citing works
Annexin A1: A Central Player in the Anti-Inflammatory and Neuroprotective Role of Microglia
McArthur, S., Cristante, E., Paterno, M., Christian, H., Roncaroli, F., Gillies, G. E., & Solito, E. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001095 · Cited by 209 · see citing works
Muraoka, S., DeLeo, A. M., Sethi, M. K., Takamatsu-Yukawa, K., Yang, Z., Ko, J., Hogan, J., Ruan, Z., You, Y., Wang, Y., et al. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.12089 · Cited by 189 · see citing works
McDonald, A. J., & Mott, D. D. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23709 · Cited by 172 · see citing works
Pathological alterations in the amygdala in Alzheimer's disease
Vogt, L. J., Hyman, B. T., Hoesen, G. W. V., & Damásio, A. R. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90408-v · Cited by 164 · see citing works
Amygdalohippocampal and Amygdalocortical Projections in the Primate Brain
Amaral, D. G. (1986) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-7971-3_1 · Cited by 158 · see citing works
Amygdalar Volume and Emotional Memory in Alzheimer’s Disease
Mori, E., Ikeda, M., Hirono, N., Kitagaki, H., Imamura, T., & Shimomura, T. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.2.216 · Cited by 154 · see citing works
Power, J. H. T., Asad, S., Chataway, T., Chegini, F., Manavis, J., Temlett, J. A., Jensen, P. H., Blumbergs, P. C., & Gai, W. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0373-3 · Cited by 152 · see citing works
CLIC1 Function Is Required for β-Amyloid-Induced Generation of Reactive Oxygen Species by Microglia
Milton, R. H., Abeti, R., Averaimo, S., Debiasi, S., Vitellaro‐Zuccarello, L., Jiang, L., Curmi, P. M. G., Breit, S. N., Duchen, M. R., & Mazzanti, M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2431-08.2008 · Cited by 148 · see citing works
The Amygdala as a Locus of Pathologic Misfolding in Neurodegenerative Diseases
Nelson, P. T., Abner, E. L., Patel, E., Anderson, S., Wilcock, D. M., Kryscio, R. J., Eldik, L. J. V., Jicha, G. A., Gal, Z. T., Nelson, R. S., et al. (2017) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlx099 · Cited by 138 · see citing works
The human olfactory system in two proteinopathies: Alzheimer’s and Parkinson’s diseases
Úbeda‐Bañón, I., Saiz‐Sánchez, D., Flores‐Cuadrado, A., Corroto, E. R., González-Rodríguez, M., Villar‐Conde, S., Astillero‐Lopez, V., Cabello, J. P., Gallardo‐Alcañiz, M. J., Vaamonde‐Gamo, J., et al. (2020) · Translational Neurodegeneration · doi:10.1186/s40035-020-00200-7 · Cited by 129 · see citing works
Self-citationVolumetric atrophy of the amygdala in Alzheimer's disease
Scott, S. A., DeKosky, S. T., & Scheff, S. W. (1991) · Neurology · doi:10.1212/wnl.41.3.351 · Cited by 120 · see citing works
Mears, D. J., & Pollard, H. B. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23705 · Cited by 118 · see citing works
Eberhard, D. A., Brown, M. D., & VandenBerg, S. R. (1994) · PubMed · Cited by 117 · see citing works
The anti-inflammatory Annexin A1 induces the clearance and degradation of the amyloid-β peptide
Ries, M., Loiola, R. A., Shah, U. N., Gentleman, S., Solito, E., & Sastre, M. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0692-6 · Cited by 106 · see citing works
Amygdala cell loss and atrophy in Alzheimer's disease
Scott, S. A., Sparks, D. L., Scheff, S. W., DeKosky, S. T., & Knox, C. A. (1992) · Annals of Neurology · doi:10.1002/ana.410320412 · Cited by 100 · see citing works
Benarroch, E. E. (2014) · Neurology · doi:10.1212/wnl.0000000000001171 · Cited by 94 · see citing works
Neuron loss and shrinkage in the amygdala in Alzheimer's disease
Vereecken, T. H. L. G., Vogels, O. J. M., & Nieuwenhuys, R. (1994) · Neurobiology of Aging · doi:10.1016/0197-4580(94)90143-0 · Cited by 85 · see citing works
Gauthier‐Kemper, A., Alonso, M. S., Sündermann, F., Niewidok, B., Fernández, M. P., Bakota, L., Heinisch, J. J., & Brandt, R. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra117.000490 · Cited by 84 · see citing works
Olfactory neuropathology in Alzheimer's disease: a sign of ongoing neurodegeneration
Son, G., Jahanshahi, A., Yoo, S., Boonstra, J. T., Hopkins, D. A., Steinbusch, H. W. M., & Moon, C. (2021) · BMB Reports · doi:10.5483/bmbrep.2021.54.6.055 · Cited by 81 · see citing works
Phosphorylated Presenilin 1 decreases β-amyloid by facilitating autophagosome–lysosome fusion
Bustos, V., Pulina, M. V., Bispo, A., Lam, A. C., Flajolet, M., Gorelick, F. S., & Greengard, P. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705240114 · Cited by 79 · see citing works
Astrocytic propagation of Tau in the context of Alzheimer's disease
Fleeman, R. M., & Proctor, E. A. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.645233 · Cited by 75 · see citing works
BM88/CEND1 coordinates cell cycle exit and differentiation of neuronal precursors
Politis, P. K., Makri, G., Thomaidou, D., Geißen, M., Rohrer, H., & Matsas, R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610973104 · Cited by 73 · see citing works
Neuropathological study of the amygdala in presenile Alzheimer's disease.
Tsuchiya, K., & Kosaka, K. (1990) · Journal of Neurological Sciences · doi:10.1016/0022-510x(90)90029-m · Cited by 69 · see citing works
The Human Hippocampus in Parkinson’s Disease: An Integrative Stereological and Proteomic Study
Villar‐Conde, S., Astillero‐Lopez, V., González-Rodríguez, M., Villanueva‐Anguita, P., Saiz‐Sánchez, D., Martı́nez-Marcos, A., Flores‐Cuadrado, A., & Úbeda‐Bañón, I. (2021) · Journal of Parkinson s Disease · doi:10.3233/jpd-202465 · Cited by 68 · see citing works
Self-citationPrion-like mechanisms in Alzheimer disease
Walker, L. C. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63945-5.00016-7 · Cited by 65 · see citing works
Amygdalar atrophy in symptomatic Alzheimer's disease based on diffeomorphometry: the BIOCARD cohort
Miller, M. I., Laurent Younes, B., Ratnanather, J. T., Brown, T., Trinh, H., Lee, D. S., Tward, D. J., Mahon, P. B., Mori, S., & Albert, M. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.06.032 · Cited by 64 · see citing works
González-Rodríguez, M., Villar‐Conde, S., Astillero‐Lopez, V., Villanueva‐Anguita, P., Úbeda‐Bañón, I., Flores‐Cuadrado, A., Martı́nez-Marcos, A., & Saiz‐Sánchez, D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010165 · Cited by 57 · see citing works
Self-citationCEND1 deficiency induces mitochondrial dysfunction and cognitive impairment in Alzheimer’s disease
Xie, W., Guo, D. S., Li, J., Yue, L., Kang, Q., Chen, G., Zhou, T., Wang, H., Zhuang, K., Leng, L., et al. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-01027-7 · Cited by 57 · see citing works
The role of glia in protein aggregation
Li, Q., & Haney, M. S. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105015 · Cited by 51 · see citing works
Astillero‐Lopez, V., González-Rodríguez, M., Villar‐Conde, S., Flores‐Cuadrado, A., Martı́nez-Marcos, A., Úbeda‐Bañón, I., & Saiz‐Sánchez, D. (2022) · Alzheimer s & Dementia · doi:10.1002/alz.12580 · Cited by 51 · see citing works
Self-citationPeroxiredoxin 6 mediates protective function of astrocytes in Aβ proteostasis
Pankiewicz, J. E., Diaz, J. R., Martá-Ariza, M., Lizińczyk, A. M., Franco, L. A., & Sadowski, M. J. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00401-8 · Cited by 45 · see citing works
The propagation mechanisms of extracellular tau in Alzheimer’s disease
Wei, Y., Liu, M., & Wang, D. (2021) · Journal of Neurology · doi:10.1007/s00415-021-10573-y · Cited by 39 · see citing works
Reiser, G., & Bernstein, H. (2002) · Neuroreport · doi:10.1097/00001756-200212200-00008 · Cited by 37 · see citing works
Evaluation of annexin A5 as a biomarker for Alzheimer's disease and dementia with lewy bodies
Sohma, H., Imai, S.-I., Takei, N., Honda, H., Matsumoto, K., Utsumi, K., Matsuki, K., Hashimoto, E., Saito, T., & Kokai, Y. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00015 · Cited by 37 · see citing works
CLIC1 Protein Accumulates in Circulating Monocyte Membrane during Neurodegeneration
Carlini, V., Verduci, I., Cianci, F., Cannavale, G., Fenoglio, C., Galimberti, D., & Mazzanti, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041484 · Cited by 35 · see citing works
Ortner, M., Pasquini, L., Barat, M., Alexopoulos, P., Grimmer, T., Förster, S., Diehl‐Schmid, J., Kurz, A., Förstl, H., Zimmer, C., et al. (2016) · Frontiers in Neurology · doi:10.3389/fneur.2016.00132 · Cited by 33 · see citing works
Centaurin-α1-Ras-Elk-1 Signaling at Mitochondria Mediates β-Amyloid-Induced Synaptic Dysfunction
Szatmari, E. M., Oliveira, A. F., Sumner, E. J., & Yasuda, R. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2641-12.2013 · Cited by 31 · see citing works
Stricker, R., & Reiser, G. (2014) · Biological Chemistry · doi:10.1515/hsz-2014-0107 · Cited by 29 · see citing works
Gál, J., Chen, J., Katsumata, Y., Fardo, D. W., Wang, W., Artiushin, S., PRICE, D. A., Anderson, S., Patel, E., Zhu, H., et al. (2017) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlx097 · Cited by 28 · see citing works
Pedrero-Prieto, C. M., Flores‐Cuadrado, A., Saiz‐Sánchez, D., Úbeda‐Bañón, I., Frontiñán-Rubio, J., Alcain, F. J., Mateos‐Hernández, L., de la Fuente, J., Durán‐Prado, M., Villar, M., et al. (2019) · Alzheimer s Research & Therapy · doi:10.1186/s13195-019-0513-0 · Cited by 27 · see citing works
Self-citationChua, X. Y., Chong, J. R., Cheng, A. L., Lee, J. H., Ballard, C. G., Aarsland, D., Francis, P. T., & Lai, M. K. P. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105251 · Cited by 26 · see citing works
Blockade of chloride intracellular ion channel 1 stimulates Aβ phagocytosis
Paradisi, S., Matteucci, A., Fabrizi, C., Denti, M. A., Abeti, R., Breit, S. N., Malchiodi‐Albedi, F., & Mazzanti, M. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21693 · Cited by 25 · see citing works
Annexin A5 Directly Interacts with Amyloidogenic Proteins and Reduces Their Toxicity
Bedrood, S., Jayasinghe, S. A., Sieburth, D., Chen, M., Erbel, S., Butler, P. C., Langen, R., & Ritzel, R. A. (2009) · Biochemistry · doi:10.1021/bi900608m · Cited by 25 · see citing works
Chapter 40: Astrocytic gliosis in the amygdala in Down's syndrome and Alzheimer's disease
Murphy, G. M., Ellis, W. G., Lee, Y. L., Stultz, K. E., Shrivastava, R. K., Tinklenberg, J. R., & Eng, L. F. (1992) · Progress in brain research · doi:10.1016/s0079-6123(08)61774-4 · Cited by 23 · see citing works
Diagnostic value of amygdala volume on structural magnetic resonance imaging in Alzheimer’s disease
Wang, D.-W., Ding, S., Bian, X., Zhou, S.-Y., Yang, H., & Wang, P. (2021) · World Journal of Clinical Cases · doi:10.12998/wjcc.v9.i18.4627 · Cited by 22 · see citing works
Sahin, H. A., Emre, M., Ziabreva, I., Perry, E. K., Celasun, B., & Perry, R. (2006) · Acta Neuropathologica · doi:10.1007/s00401-005-0003-2 · Cited by 20 · see citing works
Applying mass spectrometry-based qualitative proteomics to human amygdaloid complex
Fernández‐Irigoyen, J., Zelaya, M. V., & Santamaría, E. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00080 · Cited by 18 · see citing works
Szatmari, E. M., Moran, C., Cohen, S. J., Jacob, A., Parra-Bueno, P., Kamasawa, N., Guerrero‐Given, D., Klein, M., Stackman, R. W., & Yasuda, R. (2020) · eNeuro · doi:10.1523/eneuro.0111-20.2020 · Cited by 18 · see citing works
Gal, J., Katsumata, Y., Zhu, H., Srinivasan, S., Chen, J., Johnson, L. A., Wang, W.-X., Golden, L. R., Wilcock, D. M., Jicha, G. A., et al. (2022) · The American Journal of Pathology · doi:10.1016/j.ajpath.2021.11.013 · Cited by 17 · see citing works
Flagged first, then by citations
2 of the 67 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- [36]Mai JK, Paxinos G, Voss T. Atlas of the human brain. San Diego, CA: Academic Press; 2007.
Cited by
Sorted by citations
Modeling late-onset Alzheimer’s disease neuropathology via direct neuronal reprogramming
Sun, Z., Kwon, J.-S., Ren, Y., Chen, S., Walker, C. K., Lu, X., Cates, K., Karahan, H., Sviben, S., Fitzpatrick, J. A. J., et al. (2024) · Science · doi:10.1126/science.adl2992 · Cited by 77 · see citing works
“Among the most upregulated DEGs, higher amounts of MMP3 (52), IBSP (53), or TAGLN (54) in the brain have been linked to increased risk of AD.”
Astillero‐Lopez, V., Villar‐Conde, S., González-Rodríguez, M., Flores‐Cuadrado, A., Úbeda‐Bañón, I., Saiz‐Sánchez, D., & Martı́nez-Marcos, A. (2024) · Brain Pathology · doi:10.1111/bpa.13235 · Cited by 53 · see citing works
Self-citationWu, X., Zhu, X., Pan, Y., Gu, X., Liu, X., Chen, S. X., Zhang, Y., Xu, T., Xu, N., & Sun, S. (2024) · Aging Cell · doi:10.1111/acel.14187 · Cited by 20 · see citing works
Song, H., Lee, J., Lee, Y., Kim, S., & Kang, S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073272 · Cited by 17 · see citing works
Hagos, M. T., Curran, K. M., Namee, B. M., & Initiative, A. D. N. (2025) · Scientific Reports · doi:10.1038/s41598-025-86110-y · Cited by 14 · see citing works
Soriano-Herrador, C., Úbeda‐Bañón, I., Villanueva‐Anguita, P., Saiz‐Sánchez, D., Astillero‐Lopez, V., Martı́nez-Marcos, A., & Flores‐Cuadrado, A. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.106971 · Cited by 14 · see citing works
Self-citationCheng, Z., Nie, W., Leng, J., Yang, L., Wang, Y., Li, X., & Guo, L. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1398009 · Cited by 11 · see citing works
Shen, Y., Shen, Y., Wang, M., Jin, K., Yang, P., Cao, Z., Zhu, Q., Zhao, Z., Li, H., Han, L., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116073 · Cited by 10 · see citing works
Cell-type-specific transposon demethylation and TAD remodeling in aging mouse brain
Zeng, Q., Wang, W., Tian, W., Klein, A., Bartlett, A., Liu, H., Nery, J. R., Castanon, R., Osteen, J. K., Johnson, N. D., et al. (2026) · Cell · doi:10.1016/j.cell.2026.02.015 · Cited by 12 · see citing works
Cartas‐Cejudo, P., Cortés, A., Lachén‐Montes, M., Anaya‐Cubero, E., Puerta, E., Solas, M., Fernández‐Irigoyen, J., & Santamaría, E. (2024) · Brain Pathology · doi:10.1111/bpa.13252 · Cited by 8 · see citing works
Olfactory deficits in aging and Alzheimer’s—spotlight on inhibitory interneurons
Elhabbari, K., Sireci, S., Rothermel, M., & Brunert, D. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1503069 · Cited by 6 · see citing works
Nasir, A. R., & Nouh, C. D. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1671419 · Cited by 8 · see citing works
Sánchez-Migallón, P., Flores‐Cuadrado, A., Villanueva‐Anguita, P., Rábano, A., Vaamonde, J., Saiz‐Sánchez, D., Mohedano‐Moriano, A., Astillero‐Lopez, V., Soriano-Herrador, C., Martínez-Marcos, A., et al. (2025) · Brain Communications · doi:10.1093/braincomms/fcaf502 · Cited by 4 · see citing works
Self-citationSex-specific factors and APOEε4 genotype alter functional connectivity at middle age
Lee, B. H., McGovern, A. J., Lieblich, S. E., Mitchell, S. V., Yin, J., Epp, J. R., & Galea, L. A. M. (2025) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2025.107655 · Cited by 4 · see citing works
Kolling, L. J., Balasubramanian, N., Ismail, S., Feller, A. J., Alberhasky, J. M. H., Wang, R., Jennings, L., Hefti, M. M., & Marcinkiewcz, C. A. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71317 · Cited by 2 · see citing works
Translating Alzheimer’s disease proteomics into drug discovery opportunities
Drummond, E., Werry, E. L., Kavanagh, T., Genoud, S., Cho, A., Chen, S., Du, J., Hibbs, D. E., & Kassiou, M. (2026) · Molecular Neurodegeneration Advances · doi:10.1186/s44477-026-00035-y · Cited by 2 · see citing works
Yasuno, F., Kimura, Y., Ogata, A., Ikenuma, H., Abe, J., Minami, H., Nihashi, T., Yokoi, K., Hattori, S., Shimoda, N., et al. (2024) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2024.100795 · Cited by 2 · see citing works
Multi-scale 3D Convolutional LSTM for Longitudinal Alzheimer's Disease Identification
Guan, Z., Song, X., Yang, P., Li, J., Yang, B., Xiao, X., Liu, C.-M., Wang, T., & Lei, B. (2024) · IEEE International Symposium on Biomedical Imaging (ISBI) · doi:10.1109/isbi56570.2024.10635331 · Cited by 2 · see citing works
Ultra-high resolution multimodal MRI densely labelled holistic structural brain atlas
Manjón, J. V., Morell-Ortega, S., Ruiz-Perez, M., Mansencal, B., Bot, E. L., Gadea, M., Lanuza, E., Catheline, G., Tourdias, T., Planche, V., et al. (2026) · Scientific Reports · doi:10.1038/s41598-026-40186-2 · Cited by 1 · see citing works
Proteomic Insights into Heroin Use: Links to Neurodegeneration
Sürmen, M. G., Pençe, S., Sürmen, S., Büyük, Y., Kuraş, S., Elibol, B., & Pençe, H. H. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05757-4 · Cited by 1 · see citing works
Chavez, C. L. J., Scheldrup, G. P., Madory, L. E., Denning, C. J. E., Lee, E. C., Nguyen, D. T., Castro, M., Garcia, A., Torres-Gonzalez, J., Herbert, J. N., et al. (2024) · Addiction Biology · doi:10.1111/adb.70006 · Cited by 1 · see citing works
Li, H., Cheng, M., Zhang, N., Wang, S., Ye, C., Li, H., Wang, S., Wang, Z., Yang, X., Liu, Z., et al. (2025) · The Journal of Prevention of Alzheimer s Disease · doi:10.1016/j.tjpad.2025.100155 · Cited by 1 · see citing works
Li, Y., Su, C., & Qin, Z. S. (2026) · Briefings in Bioinformatics · doi:10.1093/bib/bbag238
Stimulus-specific recruitment of human amygdala neurons predicts episodic memory encoding success
Xiao, J., Daume, J., Salimpour, Y., Kurilenko, N., Mosher, C., Anderson, W. S., Valiante, T. A., Mamelak, A. N., & Rutishauser, U. (2026) · Nature Neuroscience · doi:10.1038/s41593-026-02493-9
Lee, C. Y., Shi, H., Ma, D., Beg, M. F., & Cao, J. (2025) · Statistics in Medicine · doi:10.1002/sim.70309
Mofrad, F. T., Pflanz, C. P., & Gallacher, J. (2025) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2025.112123
Romero-Murillo, S., Lachén‐Montes, M., Cartas‐Cejudo, P., Anaya‐Cubero, E., de Miguel, M., Extramiana, L., Ferrer, I., Fernández‐Irigoyen, J., & Santamaría, E. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.26.690815
Postu, P. A., Mihăşan, M., Gorgan, D. L., Stache, A. B., Sadiki, F. Z., Idrissi, M. E., & Hriţcu, L. (2026) · Applied Sciences · doi:10.3390/app16010511
IRIS: Interpretable Risk Clustering Intelligence for Survival Analysis
Noshin, K., Hou, B., Boland, M. R., Wen, Z., Tong, B., Shen, L., & Zhang, A. (2025) · IEEE International Conference on Big Data (BigData) · doi:10.1109/bigdata66926.2025.11402028
Brain morphological changes in acquired hearing loss: A surface-based morphometry study
Joo, H. A., Heo, H., Cheon, T.-U., Lee, Y. J., Choi, Y., Shim, W. H., & Park, H. J. (2026) · PLoS ONE · doi:10.1371/journal.pone.0343373
Sullivan, L. T., Chen, D. T., Foster, C., Zimmerman, B., Elk, K. J., Marxmiller, B. D., McGillis, T., Li, Y., Bonney, S. K., Faulhaber, L. D., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.11.717917
Romero-Murillo, S., Lachén‐Montes, M., Cartas‐Cejudo, P., Anaya‐Cubero, E., Miguel, M. D., Extramiana, L., Ferrer, I., Fernández‐Irigoyen, J., & Santamaría, E. (2026) · Biology of Sex Differences · doi:10.1186/s13293-026-00930-9
Exploring Complex Genetic Mechanisms in Brain Imaging Genetics via a New Multi-Task Learning Method
Wang, Y., Jiao, C.-N., Gao, Y.-L., Cui, X.-C., Zheng, C.-H., & Liu, J.-X. (2026) · IEEE Transactions on Computational Biology and Bioinformatics · doi:10.1109/tcbbio.2026.3709159
Amygdalar nuclei vulnerability to protein aggregates in Lewy body diseases
Deshayes, N. A. C., van Wetering, J., Wesseling, A. J., Vos, F., Ingrassia, A. M. T., Galis, Y., Jonkman, L. E., Rozemüller, A. J. M., & van de Berg, W. D. J. (2026) · Acta Neuropathologica Communications · doi:10.1186/s40478-026-02381-0
- Authors
- Gonzalez‐Rodriguez, M., Villar‐Conde, S., Astillero‐Lopez, V., Villanueva‐Anguita, P., Ubeda‐Banon, I., Flores‐Cuadrado, A., Martinez‐Marcos, A., & Saiz‐Sanchez, D.
- Affiliations
- Neuroplasticity and Neurodegeneration Laboratory, CRIB, Ciudad Real Medical School University of Castilla‐La Mancha Ciudad Real Spain
- University of Castilla-La Mancha (ES)
- ORCID
- Venue
- Brain Pathology
- Publisher
- Wiley
- Published
- 2023-06-18
- Volume
- 33
- Issue
- 5
- Pages
- e13180-e13180
- ISSN
- 1015-6305 (ISSN-L)
- 1750-3639
- PMC
- PMC10467039
- OpenAlex
- W4381110661
- Cited by
- 36
- References
- 67
- Citations by year
- 2026: 13 · 2025: 13 · 2024: 9 · 2023: 1
- FWCI
- 6.39
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Brain Pathology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RUIdeRA - Institutional University Repository (University of Castilla-La Mancha) (submittedVersion, other-oa)
- Funders
- Ministerio de Ciencia e Innovación (PID2019‐108659RB‐I00)
- Ministerio de Economía y Competitividad (SAF2016‐75768‐R)
- European Regional Development Fund (2021‐GRIN‐31233)
- European Social Fund
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, amygdala, amyloid-beta, tau protein, stereology, astrocyte activation, astrocytes, microglia, synaptic changes, olfactory bulb, temporal lobe, human brain tissue
- MeSH terms
- Alzheimer Disease, Amygdala, Brain, Humans, Amyloid beta-Peptides, tau Proteins, Microglia, Proteomics
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