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Alterations of the endocannabinoid system and its therapeutic potential in autism spectrum disorder

Zou, M., Liu, Y., Xie, S. H., Wang, L., Li, D., Li, L., Wang, F., Zhang, Y., Xia, W. T., Sun, C., et al. (2021) · Open Biology · doi:10.1098/rsob.200306 · Cited by 58 · see citing works

The neurobiology of social play behaviour: Past, present and future

Achterberg, E. J. M., & Vanderschuren, L. J. M. J. (2023) · Neuroscience &amp; Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105319 · Cited by 56 · see citing works

Three Decades of Valproate: A Current Model for Studying Autism Spectrum Disorder

Zárate-López, D., Torres-Chávez, A. L., Gálvez‐Contreras, A. Y., & González-Pérez, Ó. (2023) · Current Neuropharmacology · doi:10.2174/1570159x22666231003121513 · Cited by 56 · see citing works

Loss of Mevalonate/Cholesterol Homeostasis in the Brain: A Focus on Autism Spectrum Disorder and Rett Syndrome

Segatto, M., Tonini, C., Pfrieger, F. W., Trezza, V., & Pallottini, V. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133317 · Cited by 51 · see citing works

Gender-specific approach in psychiatric diseases: Because sex matters

Franceschini, A., & Fattore, L. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.173895 · Cited by 51 · see citing works

Probiotics and Prebiotics Alleviate Behavioral Deficits, Inflammatory Response and Gut Dysbiosis in Prenatal VPA-Induced Rodent Model of Autism

Adıgüzel, E., Çiçek, B., Ünal, G., Aydın, M. F., & Keti, D. B. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.113961 · Cited by 51 · see citing works

Cannabidiol for the treatment of autism spectrum disorder: hope or hype?

Pedrazzi, J. F. C., Ferreira, F. R., Silva-Amaral, D., Lima, D. D. A., Hallak, J. E. C., Zuardi, A. W., Bel, E. A. D., Guimarães, F. S., Costa, K. C. M., Campos, A. C., et al. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06196-4 · Cited by 52 · see citing works

Attenuation of neurobehavioural abnormalities by papaverine in prenatal valproic acid rat model of ASD

Luhach, K., Kulkarni, G. T., Singh, V. P., & Sharma, B. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173663 · Cited by 46 · see citing works

Vinpocetine amended prenatal valproic acid induced features of ASD possibly by altering markers of neuronal function, inflammation, and oxidative stress

Luhach, K., Kulkarni, G. T., Singh, V. P., & Sharma, B. (2021) · Autism Research · doi:10.1002/aur.2597 · Cited by 49 · see citing works

Pathophysiological Studies of Monoaminergic Neurotransmission Systems in Valproic Acid-Induced Model of Autism Spectrum Disorder

Kuo, H., & Liu, F. (2022) · Biomedicines · doi:10.3390/biomedicines10030560 · Cited by 45 · see citing works

Targeting the inhibition of fatty acid amide hydrolase ameliorate the endocannabinoid-mediated synaptic dysfunction in a valproic acid-induced rat model of Autism

Wu, H.-F., Lu, T.-Y., Chu, M.-C., Chen, P. S., Lee, C. J., & Lin, H. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107736 · Cited by 45 · see citing works

Targeting PPARα in the rat valproic acid model of autism: focus on social motivational impairment and sex-related differences

Scheggi, S., Guzzi, F., Braccagni, G., Montis, M. G. D., Parenti, M. D., & Gambarana, C. (2020) · Molecular Autism · doi:10.1186/s13229-020-00358-x · Cited by 42 · see citing works

Valproic acid exposure impairs ultrasonic communication in infant, adolescent and adult rats

Gzieło, K., Potasiewicz, A., Hołuj, M., Litwa, E., Popik, P., & Nikiforuk, A. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2020.09.006 · Cited by 41 · see citing works

Influence of Prenatal Drug Exposure, Maternal Inflammation, and Parental Aging on the Development of Autism Spectrum Disorder

Sato, A., Kotajima‐Murakami, H., Tanaka, M., Katoh, Y., & Ikeda, K. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.821455 · Cited by 42 · see citing works

Healing autism spectrum disorder with cannabinoids: a neuroinflammatory story

Carbone, E., Manduca, A., Cacchione, C., Vicari, S., & Trezza, V. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.12.009 · Cited by 37 · see citing works

Targeting oxytocin receptor (Oxtr)-expressing neurons in the lateral septum to restore social novelty in autism spectrum disorder mouse models

Horiai, M., Otsuka, A., Hidema, S., Hiraoka, Y., Hayashi, R., Miyazaki, S., Furuse, T., Mizukami, H., Teruyama, R., Tamura, M., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-79109-0 · Cited by 35 · see citing works

The neurochemistry of social reward during development: What have we learned from rodent models?

Manduca, A., Carbone, E., Schiavi, S., Cacchione, C., Buzzelli, V., Campolongo, P., & Trezza, V. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15321 · Cited by 34 · see citing works

Therapeutic potential of cannabidivarin for epilepsy and autism spectrum disorder

Zamberletti, E., Rubino, T., & Parolaro, D. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107878 · Cited by 35 · see citing works

Lutein-loaded nanoparticles reverse oxidative stress, apoptosis, and autism spectrum disorder-like behaviors induced by prenatal valproic acid exposure in female rats

Viana, C. E., Bortolotto, V. C., Araújo, S. M., Dahleh, M. M. M., Machado, F. R., Pereira, A. D. S., de Oliveira, B. P. M., Leimann, F. V., Gonçalves, O. H., Prigol, M., et al. (2022) · NeuroToxicology · doi:10.1016/j.neuro.2022.12.006 · Cited by 34 · see citing works

A systematic review of cannabidiol trials in neurodevelopmental disorders

Parrella, N.-F., Hill, A. T., Enticott, P. G., Barhoun, P., Bower, I. S., & Ford, T. C. (2023) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2023.173607 · Cited by 34 · see citing works

The role of neuroglia in autism spectrum disorders

Scuderi, C., & Verkhratsky, A. (2020) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2020.04.011 · Cited by 29 · see citing works

Role of the endocannabinoid system in neurological disorders

Zou, M., Li, D., Li, L., Wu, L., & Sun, C. (2019) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2019.03.002 · Cited by 28 · see citing works

Increasing Endocannabinoid Tone Alters Anxiety-Like and Stress Coping Behaviour in Female Rats Prenatally Exposed to Valproic Acid

Thornton, A. M., Humphrey, R. M., Kerr, D. M., Finn, D. P., & Roche, M. (2021) · Molecules · doi:10.3390/molecules26123720 · Cited by 28 · see citing works

Emerging pharmacological therapies in fragile X syndrome and autism

Yamasue, H., Aran, A. A., & Berry‐Kravis, E. (2019) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000703 · Cited by 27 · see citing works

Is Cannabidiol During Neurodevelopment a Promising Therapy for Schizophrenia and Autism Spectrum Disorders?

Loss, C. M., Teodoro, L., Rodrigues, G. D., Moreira, L. R., Peres, F. F., Zuardi, A. W., Crippa, J. A. S., Hallak, J. E. C., & Abílio, V. C. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.635763 · Cited by 27 · see citing works

Effects of prenatal exposure to valproic acid or poly(I:C) on ultrasonic vocalizations in rat pups: The role of social cues

Potasiewicz, A., Gzieło, K., Popik, P., & Nikiforuk, A. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113113 · Cited by 25 · see citing works

The Effect of Maternal Immune Activation on Social Play-Induced Ultrasonic Vocalization in Rats

Gzieło, K., Potasiewicz, A., Litwa, E., Piotrowska, D., Popik, P., & Nikiforuk, A. (2021) · Brain Sciences · doi:10.3390/brainsci11030344 · Cited by 26 · see citing works

Anandamide and 2-arachidonoylglycerol differentially modulate autistic-like traits in a genetic model of autism based on FMR1 deletion in rats

Schiavi, S., Manduca, A., Carbone, E., Buzzelli, V., Rava, A., Feo, A., Ascone, F., Morena, M., Campolongo, P., Hill, M. N., et al. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01454-7 · Cited by 26 · see citing works

Maternal Immune Activation Induced by Prenatal Lipopolysaccharide Exposure Leads to Long-Lasting Autistic-like Social, Cognitive and Immune Alterations in Male Wistar Rats

Carbone, E., Buzzelli, V., Manduca, A., Leone, S., Rava, A., & Trezza, V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043920 · Cited by 26 · see citing works

D-aspartate oxidase gene duplication induces social recognition memory deficit in mice and intellectual disabilities in humans

Lombardo, B., Pagani, M., Rosa, A. D., Nunziato, M., Migliarini, S., Garofalo, M., Terrile, M., D’Argenio, V., Galbusera, A., Nuzzo, T., et al. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02088-5 · Cited by 25 · see citing works

Hyperactivation of the amygdala correlates with impaired social play behavior of prepubertal male rats in a maternal immune activation model

Vitor-Vieira, F., Vilela, F. C., & Giusti‐Paiva, A. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113503 · Cited by 24 · see citing works

Prenatally VPA exposure is likely to cause autistic-like behavior in the rats offspring via TREM2 down-regulation to affect the microglial activation and synapse alterations

Luo, L., Chen, J., Wu, Q., Yuan, B., Hu, C., Yang, T., Wei, H., & Li, T. (2023) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2023.104090 · Cited by 24 · see citing works

Cilostazol attenuated prenatal valproic acid-induced behavioural and biochemical deficits in a rat model of autism spectrum disorder

Luhach, K., Kulkarni, G. T., Singh, V. P., & Sharma, B. (2021) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgab115 · Cited by 23 · see citing works

Psilocybin mitigates the cognitive deficits observed in a rat model of Fragile X syndrome

Buzzelli, V., Carbone, E., Manduca, A., Schiavi, S., Feo, A., Perederiy, J. V., Ambert, K. H., Hausman, M., & Trezza, V. (2023) · Psychopharmacology · doi:10.1007/s00213-022-06286-3 · Cited by 22 · see citing works

On the Digital Psychopharmacology of Valproic Acid in Mice

Bass, J. S., Tuo, A., Ton, L. T., Jankovic, M. J., Kapadia, P., Schirmer, C., & Krishnan, V. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.594612 · Cited by 22 · see citing works

Histamine H3 receptor antagonist, ciproxifan, alleviates cognition and synaptic plasticity alterations in a valproic acid-induced animal model of autism

Taheri, F., Esmaeilpour, K., Sepehri, G., Sheibani, V., Rehman, N. U., & Maneshian, M. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06155-z · Cited by 22 · see citing works

Bifidobacterium animalis subsp. lactis Probio-M8 alleviates abnormal behavior and regulates gut microbiota in a mouse model suffering from autism

Miao, Z., Chen, L., Zhang, Y., Zhang, J., & Zhang, H. (2023) · mSystems · doi:10.1128/msystems.01013-23 · Cited by 27 · see citing works

Prenatal exposure to valproate induces sex-, age-, and tissue-dependent alterations of cholesterol metabolism: Potential implications on autism

Cartocci, V., Tonini, C., Di Pippo, T., Vuono, F., Schiavi, S., Marino, M., Trezza, V., & Pallottini, V. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.27218 · Cited by 22 · see citing works

Subtle alterations in neonatal neurodevelopment following early or late exposure to prenatal maternal immune activation in mice

Guma, E., Snook, E., Spring, S., Lerch, J. P., Nieman, B. J., Devenyi, G. A., & Chakravarty, M. M. (2021) · NeuroImage Clinical · doi:10.1016/j.nicl.2021.102868 · Cited by 20 · see citing works

Developmental vitamin D deficiency increases foetal exposure to testosterone

Ali, A. A., Cui, X., Pértile, R. A. N., Li, X., Medley, G., Alexander, S., Whitehouse, A., McGrath, J. J., & Eyles, D. W. (2020) · Molecular Autism · doi:10.1186/s13229-020-00399-2 · Cited by 20 · see citing works

Prenatal exposure to valproic acid reduces social responses and alters mRNA levels of opioid receptor and pre-pro-peptide in discrete brain regions of adolescent and adult male rats

Hughes, E. M., Calcagno, P., Clarke, M., Sánchez, C., Smith, K. L., Kelly, J. P., Finn, D. P., & Roche, M. (2020) · Brain Research · doi:10.1016/j.brainres.2020.146675 · Cited by 19 · see citing works

N-Acetylcysteine Mitigates Social Dysfunction in a Rat Model of Autism Normalizing Glutathione Imbalance and the Altered Expression of Genes Related to Synaptic Function in Specific Brain Areas

Schiavi, S., Rosa, P. L., Petrillo, S., Carbone, E., D’Amico, J., Piemonte, F., & Trezza, V. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.851679 · Cited by 18 · see citing works

Quantitative and Qualitative Sex Modulations in the Brain Anatomy of Autism

Hammill, C. F., Lerch, J. P., Taylor, M. J., Ameis, S. H., Chakravarty, M. M., Szatmári, P., Anagnostou, E. A., & Lai, M. (2021) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2021.03.001 · Cited by 16 · see citing works

Phosphodiesterase 2A inhibition corrects the aberrant behavioral traits observed in genetic and environmental preclinical models of Autism Spectrum Disorder

Schiavi, S., Carbone, E., Melancia, F., di Masi, A., Jarjat, M., Brau, F., Cardarelli, S., Giorgi, M., Bardoni, B., & Trezza, V. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01885-2 · Cited by 15 · see citing works

Effects of endocannabinoid system modulation on social behaviour: A systematic review of animal studies

Ahmed, M., Best, L. M., Pereira, C. F., Boileau, I., & Kloiber, S. M. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104680 · Cited by 14 · see citing works

Potential of cannabinoids as treatments for autism spectrum disorders

Nezgovorova, V., Ferretti, C. J., Taylor, B. P., Shanahan, E. C., Uzunova, G., Hong, K., Devinsky, O., & Hollander, E. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.02.048 · Cited by 15 · see citing works

Endocannabinoid system involvement in autism spectrum disorder: An overview with potential therapeutic applications

Schultz, S. T., Siniscalco, D., & 3 Italian Group for Study Autism-GISA, 2. B. (2019) · AIMS molecular science · doi:10.3934/molsci.2019.1.27 · Cited by 15 · see citing works

Cannabinoid treatment for the symptoms of autism spectrum disorder

Aran, A. A., & Cayam-Rand, D. (2024) · Expert Opinion on Emerging Drugs · doi:10.1080/14728214.2024.2306290 · Cited by 14 · see citing works

Endocannabinoid System Unlocks the Puzzle of Autism Treatment via Microglia

Su, T., Yan, Y., Li, Q., Ye, J., & Pei, L. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.734837 · Cited by 14 · see citing works

Long-lasting impact of perinatal dietary supplementation of omega 3 fatty acids on mevalonate pathway: potential role on neuron trophism in male offspring hippocampal formation

Tonini, C., Schiavi, S., Macca, F., Segatto, M., Trezza, V., & Pallottini, V. (2020) · Nutritional Neuroscience · doi:10.1080/1028415x.2020.1724452 · Cited by 13 · see citing works

A Functional Signature in the Developing Cerebellum: Evidence From a Preclinical Model of Autism

Soria-Ortiz, M. B., Reyes-Ortega, P., Martínez‐Torres, A., & Reyes‐Haro, D. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.727079 · Cited by 13 · see citing works

Sex differences in autism‐like behavior and dopaminergic neurons in substantia nigra of juvenile mice prenatally exposed to valproate

Zárate-López, D., Garzón‐Partida, A. P., González-Pérez, Ó., & Gálvez‐Contreras, A. Y. (2024) · Developmental Psychobiology · doi:10.1002/dev.22469 · Cited by 13 · see citing works

Prenatal Valproic Acid Induces Autistic‐Like Behaviors in Rats via Dopaminergic Modulation in Nigrostriatal and Mesocorticolimbic Pathways

Cezar, L. C., da Fonseca, C. C. N., Klein, M., Kirsten, T. B., & Felício, L. F. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.16282 · Cited by 13 · see citing works

The comparative effectiveness of metformin and risperidone in a rat model of valproic acid-induced autism, Potential role for enhanced autophagy

Atia, A. A., Ashour, R. H., Zaki, M. M., Rahman, K. A., & Ramadan, N. M. (2023) · Psychopharmacology · doi:10.1007/s00213-023-06371-1 · Cited by 12 · see citing works

Cannabidiol improves maternal obesity-induced behavioral, neuroinflammatory and neurochemical dysfunctions in the juvenile offspring

Rodrigues, F. D. S., Jantsch, J., Fraga, G. D. F., Milczarski, V. L. D. C., Dias, V. S., Scheid, C., Merib, J. D. O., Giovernardi, M., & Guedes, R. P. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.04.010 · Cited by 13 · see citing works

An alpha 5‐GABAA receptor positive allosteric modulator attenuates social and cognitive deficits without changing dopamine system hyperactivity in rats exposed to valproic acid in utero

Souza, A. J., Freitas, I. D. S., Sharmin, D., Cook, J. M., Guimarães, F. S., & Gomes, F. V. (2024) · Autism Research · doi:10.1002/aur.3178 · Cited by 13 · see citing works

Prenatal exposure to valproic acid induces sex-specific alterations in rat cortical and hippocampal neuronal structure and function in vitro

Williams, O. O. F., Coppolino, M., Micelli, C. B., McCallum, R. T., Henry-Duru, P. T., Manduca, J. D., Lalonde, J., & Perreault, M. L. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.111222 · Cited by 12 · see citing works

Group I and group II metabotropic glutamate receptors are upregulated in the synapses of infant rats prenatally exposed to valproic acid

D’Antoni, S., Schiavi, S., Buzzelli, V., Giuffrida, S., Feo, A., Ascone, F., Busceti, C. L., Nicoletti, F., Trezza, V., & Catania, M. V. (2023) · Psychopharmacology · doi:10.1007/s00213-023-06457-w · Cited by 12 · see citing works

Alterations in the autonomic nerve activities of prenatal autism model mice treated with valproic acid at different developmental stages

Kasahara, Y., Yoshida, C., Nakanishi, K., Fukase, M., Suzuki, A., & Kimura, Y. (2020) · Scientific Reports · doi:10.1038/s41598-020-74662-0 · Cited by 12 · see citing works

The endocannabinoid system in social anxiety disorder: from pathophysiology to novel therapeutics

Ahmed, M., Boileau, I., Le Foll, B., Carvalho, A. F., & Kloiber, S. (2022) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2021-1926 · Cited by 11 · see citing works

Music alleviates cognitive impairments in an animal model of autism

Taheri, F., Joushi, S., Esmaeilpour, K., Sheibani, V., Ebrahimi, M. N., & Zadeh, Z. T. (2023) · International Journal of Developmental Neuroscience · doi:10.1002/jdn.10260 · Cited by 11 · see citing works

Defects in AMPAR trafficking and microglia activation underlie socio-cognitive deficits associated to decreased expression of phosphodiesterase 2 a

Delhaye, S., Jarjat, M., Boulksibat, A., Sanchez, C., Tempio, A., Turtoï, A., Giorgi, M., Lacas‐Gervais, S., Baj, G., Rovère, C., et al. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106393 · Cited by 11 · see citing works

Vinpocetine ameliorates developmental hyperserotonemia induced behavioral and biochemical changes: role of neuronal function, inflammation, and oxidative stress

Luhach, K., Kulkarni, G. T., Singh, V. P., & Sharma, B. (2022) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2022-004 · Cited by 10 · see citing works

Sex differences in the BTBR idiopathic mouse model of autism spectrum disorders: Behavioural and redox-related hippocampal alterations

Bové, M., Sikora, V., Santoro, M., Agosti, L. P., Palmieri, M. A., Dimonte, S., Tucci, P., Schiavone, S., Morgese, M. G., & Trabace, L. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110134 · Cited by 10 · see citing works

Increased volumes of lobule VI in a valproic acid model of autism are associated with worse set-shifting performance in male Long-Evan rats

Payne, M. M., Mali, I., McKinnell, Z. E., Vangsness, L., Shrestha, T. B., Bossmann, S. H., & Plakke, B. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147495 · Cited by 10 · see citing works

Comparative effect of atorvastatin and risperidone on modulation of TLR4/NF-κB/NOX-2 in a rat model of valproic acid-induced autism

Farrag, E. A. E., Askar, M. H., Abdallah, Z., Mahmoud, S. M., Abdulhai, E. A., Abdel-Razik, E. A., Nashar, E. M. E., Alasiri, F. M., Alqahtani, A. N. S., Eldesoqui, M. B., et al. (2024) · Behavioral and Brain Functions · doi:10.1186/s12993-024-00250-1 · Cited by 10 · see citing works

Therapeutic potential of CBD in Autism Spectrum Disorder

Pedrazzi, J. F. C., Hassib, L., Ferreira, F. R., Hallak, J. E. C., Del-Bel, E., & Crippa, J. A. S. (2024) · International review of neurobiology · doi:10.1016/bs.irn.2024.05.002 · Cited by 11 · see citing works

Impact of Sex and Age on the Mevalonate Pathway in the Brain: A Focus on Effects Induced by Maternal Exposure to Exogenous Compounds

Tonini, C., Segatto, M., & Pallottini, V. (2020) · Metabolites · doi:10.3390/metabo10080304 · Cited by 9 · see citing works

Acute cannabidiol treatment reverses behavioral impairments induced by embryonic valproic acid exposure in male mice

Pedrazzi, J. F. C., Sales, A. J., Ponciano, R., Ferreira, L. G., Ferreira, F. R., Campos, A. C., Hallak, J. E. C., Zuardi, A. W., Bel, E. A. D., Guimarães, F. S., et al. (2024) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2024.173919 · Cited by 9 · see citing works

The Effect of Valproic Acid Administration on Learning, Social Interaction, and Depression Induced by Withdrawal Syndrome in Morphine-dependent Mice

Farhadi, M., Sabzalizadeh, M., Shamsara, A., & Afarinesh, M. R. (2024) · Addiction and Health · doi:10.34172/ahj.1511 · Cited by 8 · see citing works

Early postnatal hypothyroidism reduces juvenile play behavior, but prenatal hypothyroidism compensates for these effects

Northcutt, K. V., Leal-Medina, T. S., & Yoon, Y. S. (2021) · Physiology & Behavior · doi:10.1016/j.physbeh.2021.113594 · Cited by 8 · see citing works

Mu-opioid receptor agonism differentially alters social behaviour and immediate early gene expression in male adolescent rats prenatally exposed to valproic acid versus controls

Hughes, E. M., Calcagno, P., Sánchez, C., Smith, K. L., Kelly, J. P., Finn, D. P., & Roche, M. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.06.018 · Cited by 8 · see citing works

Alterations in the intrinsic discharge activity of CA1 pyramidal neurons associated with possible changes in the NADPH diaphorase activity in a rat model of autism induced by prenatal exposure to valproic acid

Rahdar, M., Hajisoltani, R., Davoudi, S., Karimi, S. A., Borjkhani, M., Khatibi, V. A., Hosseinmardi, N., Behzadi, G., & Janahmadi, M. (2022) · Brain Research · doi:10.1016/j.brainres.2022.148013 · Cited by 8 · see citing works

Spontaneous Calcium Transients Recorded from Striatal Astrocytes in a Preclinical Model of Autism

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Outcomes of early social experiences on glucocorticoid and endocannabinoid systems in the prefrontal cortex of male and female adolescent rats

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Prenatal Pregabalin Exposure Alters Postnatal Pain Sensitivity and Some Behavioral Responses in Adult Offspring Rats

Meymandi, M. S., Sepehri, G., Moslemizadeh, A., & Shahrbabaki, S. S. V. (2020) · Current Drug Safety · doi:10.2174/1574886315666200628114257 · Cited by 7 · see citing works

In silico analyses of the involvement of GPR55, CB1R and TRPV1: response to THC, contribution to temporal lobe epilepsy, structural modeling and updated evolution

Cherry, A. L., Wheeler, M. J., Mathisova, K., & Miceli, M. D. (2024) · Frontiers in Neuroinformatics · doi:10.3389/fninf.2024.1294939 · Cited by 7 · see citing works

Augmentation of Endogenous 2-Arachidonoylglycerol Mitigates Autistic Behaviors of BTBR Mice

Zou, M., Zhang, Y., Du, C., Yang, B., Guo, P., Liang, H., Zhang, Y., Tian, W., Yang, L., Liu, D., et al. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04606-6 · Cited by 6 · see citing works

FMR1 deletion in rats induces hyperactivity with no changes in striatal dopamine transporter availability

D’Elia, A., Schiavi, S., Manduca, A., Rava, A., Buzzelli, V., Ascone, F., Orsini, T., Putti, S., Soluri, A., Galli, F., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-26986-2 · Cited by 6 · see citing works

Kappa Opioid Receptor-mediated Modulation of Social Responding in Adolescent Rats and in Rats Prenatally Exposed to Valproic Acid

Hughes, E. M., Thornton, A. M., Kerr, D. M., Smith, K. L., Sánchez, C., Kelly, J. P., Finn, D. P., & Roche, M. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.07.055 · Cited by 6 · see citing works

Assessment of Empathy‐Like Behaviour in Valproic Acid–Induced Rat Model of Autism

Tunçak, S., Gören, B., Uzbay, T. I., & Öz, P. (2025) · International Journal of Developmental Neuroscience · doi:10.1002/jdn.70008 · Cited by 5 · see citing works

Testing the extreme male hypothesis in the valproate mouse model; sex-specific effects on plasma testosterone levels and tyrosine hydroxylase expression in the anteroventral periventricular nucleus, but not on parental behavior

Grgurevič, N. (2023) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2023.1107226 · Cited by 5 · see citing works

Maternal treatment with aripiprazole prevents the development of a valproic acid-induced autism-like phenotype in juvenile male mice

Ferreira, E. D. O., Gomes, J. M. P., Neves, K. R. T., Lima, F. A. V., Viana, G. S. D. B., & de Andrade, G. M. (2023) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000718 · Cited by 5 · see citing works

Intraamygdaloid Oxytocin Increases Time Spent on Social Interaction in Valproate-Induced Autism Animal Model

Vörös, D., Kiss, O., Ollmann, T., Mintál, K., Péczely, L., Zagorácz, O., Kertes, E., Kállai, V., László, B. R., Berta, B., et al. (2023) · Biomedicines · doi:10.3390/biomedicines11071802 · Cited by 5 · see citing works

The Role of Intraamygdaloid Oxytocin and D2 Dopamine Receptors in Reinforcement in the Valproate-Induced Autism Rat Model

László, K., Vörös, D., Kiss, O., László, B. R., Ollmann, T., Péczely, L., Mintál, K., Tóth, A., Kovács, A., Zagorácz, O., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10092309 · Cited by 6 · see citing works

Alterations of the endocannabinoid system in autism spectrum disorder: a systematic review and meta-analysis

Jia, X., Gao, S., Liu, X., Feng, Z., Wang, X. X., Lan, K., Lu, Y., Han, L., Wei, Y. B., & Liu, J. (2025) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-025-02031-x · Cited by 4 · see citing works

Effects of music on cognitive behavioral impairments in both sex of adult rats exposed prenatally to valproic acid

Taheri, F., Joushi, S., Mohammadipoor‐Ghasemabad, L., Rad, I., Esmaeilpour, K., & Sheibani, V. (2024) · Birth Defects Research · doi:10.1002/bdr2.2300 · Cited by 4 · see citing works

Targeting anandamide metabolism rescues core and associated autistic-like symptoms in rats prenatally exposed to valproic acid

Servadio, M., Melancia, F., Manduca, A., di Masi, A., Schiavi, S., Cartocci, V., Pallottini, V., Campolongo, P., Ascenzi, P., & Trezza, V. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.182 · Cited by 139 · see citing works

The role of the endocannabinoid system in neuronal alterations and behavioural responding in the valproic acid model of autism

Thornton, A. M. (2020) · Arrow@dit (Dublin Institute of Technology) · doi:10.13025/17049

Increasing Endocannabinoid Tone Alters Anxiety-Like and Stress Coping Behaviour in Female Rats Prenatally Exposed to Valproic Acid

Thornton, A. M., Humphrey, R. M., Kerr, D. M., Finn, D. P., & Roche, M. (2021) · Molecules · doi:10.3390/molecules26123720 · Cited by 28 · see citing works

Sex-specific effects of prenatal valproic acid exposure on sociability and neuroinflammation: Relevance for susceptibility and resilience in autism

Kazlauskas, N., Seiffe, A., Campolongo, M., Zappala, C., & Depino, A. M. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104441 · Cited by 71 · see citing works

Sex-related differences in the behavioral phenotype and associated impairments in the dopaminergic, endocannabinoid and PPAR alpha systems in a rat model of autism

Salviati, S. (2026) · Use Siena air (University of Siena)