Th1‐type immune responses to Porphyromonas gingivalis antigens exacerbate angiotensin II‐dependent hypertension and vascular dysfunction
Open accessAbstract
BACKGROUND AND PURPOSE: Emerging evidence indicates that hypertension is mediated by immune mechanisms. We hypothesized that exposure to Porphyromonas gingivalis antigens, commonly encountered in periodontal disease, can enhance immune activation in hypertension and exacerbate the elevation in BP, vascular inflammation and vascular dysfunction. EXPERIMENTAL APPROACH: ) were studied, and vascular inflammation was quantified by flow cytometry and real-time PCR. KEY RESULTS: Systemic T-cell activation, a characteristic of hypertension, was exacerbated by P. gingivalis antigen stimulation. This translated into increased aortic vascular inflammation with enhanced leukocyte, in particular, T-cell and macrophage infiltration. The expression of the Th1 cytokines, IFN-γ and TNF-α, and the transcription factor, TBX21, was increased in aortas of P. gingivalis/IL-12/aluminium oxide-immunized mice, while IL-4 and TGF-β were unchanged. These immune changes in mice with induced T-helper-type 1 immune responses were associated with an enhanced elevation of BP and endothelial dysfunction compared with control mice in response to 2 week infusion of a subpressor dose of angiotensin II. CONCLUSIONS AND IMPLICATIONS: These results support the concept that Th1 immune responses induced by bacterial antigens such as P. gingivalis can increase sensitivity to subpressor pro-hypertensive insults such as low-dose angiotensin II, thus providing a mechanistic link between chronic infection, such as periodontitis, and hypertension. LINKED ARTICLES: This article is part of a themed section on Immune Targets in Hypertension. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.12/issuetoc.
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An immune response to Porphyromonas gingivalis results in elevation of blood pressure, vascular inflammation, and endothelial dysfunction in experimental animals.
“Emerging experimental animal evidence indicates that an immune response to a common periodontal pathogen: Porphyromonas gingivalis (Pg) results in elevation of BP, vascular inflammation, and endothelial dysfunction.78”
From Periodontitis is associated with hypertension: a systematic review and meta-analysis (2020) · cites this paper as [78]
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Periodontitis is associated with hypertension: a systematic review and meta-analysis
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- Authors
- Czesnikiewicz‐Guzik, M., Nosalski, R., Mikolajczyk, T. P., Vidler, F., Dohnal, T., Dembowska, E., Graham, D., Harrison, D. G., & Guzik, T. J.
- Affiliations
- Department of Periodontology and Oral Sciences Research Group, University of Glasgow Dental School and Institute of Infection, Immunity and Inflammation University of Glasgow Glasgow UK
- University of Glasgow (GB)
- Jagiellonian University (PL)
- Department of Periodontology Pomeranian Medical University Szczecin Poland
- Vanderbilt University (US)
- ORCID
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2018-12-26
- Volume
- 176
- Issue
- 12
- Pages
- 1922-1931
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- PMC
- PMC6534780
- OpenAlex
- W2899545787
- Cited by
- 61
- References
- 55
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 3 · 2023: 10 · 2022: 10 · 2021: 12 · 2020: 6 · 2019: 5
- FWCI
- 6.60
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- British Journal of Pharmacology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion, cc-by-sa)
- Homo Politicus (Academy of Humanities and Economics in Lodz) (submittedVersion, cc-by-nc-nd)
- Jagiellonian University Repository (Jagiellonian University) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institutes of Health (HL‐390006, AR‐42527, AI‐44142, EY‐11916, AR‐41974)
- H2020 European Research Council (726318)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- Porphyromonas gingivalis, Th1 response, hypertension, angiotensin II, vascular dysfunction, endothelial dysfunction, vascular inflammation, periodontitis, T cell activation, interferon-gamma, TNF-α, TBX21, macrophage infiltration, bacterial antigens
- MeSH terms
- Angiotensin II, Animals, Antigens, Bacterial, Dose-Response Relationship, Drug, Flow Cytometry, Hypertension, Inflammation, Male, Mice, Inbred C57BL, Porphyromonas gingivalis, Th1 Cells, Ventricular Dysfunction, Mice
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