Pathological periodontal pockets are associated with raised diastolic blood pressure in obese adolescents
Open accessAbstract
BACKGROUND: Obesity, a well-known risk factor for developing cardiovascular disease (CVD), is associated with chronic periodontitis in adults. This cross-sectional pilot study on obese adolescents was designed to investigate whether periodontal disease in terms of pathological periodontal pockets is associated with raised blood pressure and other risk markers for CVD. METHODS: The study included 75 obese subjects between 12 to 18 years of age, mean 14.5. Subjects answered a questionnaire regarding health, oral hygiene habits and sociodemographic factors. A clinical examination included Visible Plaque Index (VPI %), Gingival inflammation (BOP %) and the occurrence of pathological pockets exceeding 4 mm (PD ≥ 4 mm). Blood serum were collected and analyzed. The systolic and diastolic blood pressures were registered. RESULTS: Adolescents with pathological periodontal pockets (PD ≥ 4 mm; n = 14) had significantly higher BOP >25% (P = 0.002), higher diastolic blood pressure (P = 0.008), higher levels of Interleukin (IL)-6 (P < 0.001), Leptin (P = 0.018), Macrophage Chemoattractant Protein-1 (MCP-1) (P = 0.049) and thyroid stimulating hormone (TSH) (P = 0.004) in blood serum compared with subjects without pathological periodontal pockets (PD ≥ 4 mm; n = 61). The bivariate linear regression analysis demonstrated that PD ≥ 4 mm (P = 0.008) and systolic blood pressure (P < 0.001) were significantly associated with the dependent variable "diastolic blood pressure". The association between PD ≥ 4 mm and diastolic blood pressure remained significant (P = 0.006) even after adjusting for potential confounders BMI-sds, age, gender, mother's country of birth, BOP >25%, IL-6, IL-8, Leptin, MCP-1, TSH and total cholesterol in the multiple regression analysis. CONCLUSION: In conclusion, this study indicates an association between pathological periodontal pockets and diastolic blood pressure in obese adolescents. The association was unaffected by other risk markers for cardiovascular events or periodontal disease. The results call for collaboration between pediatric dentists and medical physicians in preventing obesity development and its associated disorders.
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Several studies appear to support a relationship between severe periodontitis and hypertension.
“Several studies appear to support a relationship between severe periodontitis and hypertension.[24][25][26][27]”
From Periodontitis is associated with hypertension: a systematic review and meta-analysis (2020) · cites this paper as [26]
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Periodontitis is associated with hypertension: a systematic review and meta-analysis
Muñoz Aguilera, E., Suvan, J., Buti, J., Czesnikiewicz-Guzik, M., Barbosa Ribeiro, A., Orlandi, M., Guzik, T. J., Hingorani, A. D., Nart, J., & D’Aiuto, F. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvz201 · Cited by 394 · see citing works
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- Authors
- Zeigler, C. C., Wondimu, B., Marcus, C., & Modéer, T.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Zeigler, Cecilia C
- Venue
- BMC Oral Health
- Published
- 2015-03-24
- Volume
- 15
- Issue
- 1
- Pages
- 41-41
- ISSN
- 1472-6831 (ISSN-L)
- PMC
- PMC4373518
- OpenAlex
- W2075794272
- Cited by
- 41
- References
- 52
- Citations by year
- 2025: 4 · 2024: 1 · 2023: 2 · 2022: 9 · 2021: 4 · 2020: 5 · 2019: 7 · 2018: 4 · 2017: 2 · 2016: 1 · 2015: 2
- FWCI
- 4.05
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- BMC Oral Health (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Forskningsrådet för Arbetsliv och Socialvetenskap
- Karolinska Institutet
- Stockholms Läns Landsting
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Health Professions › Pharmacy › Oral and gingival health research
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- diastolic blood pressure, adolescent obesity, chronic periodontitis, cardiovascular risk factors, interleukin-6, leptin, MCP-1, thyroid-stimulating hormone, gingivitis, periodontal disease
- MeSH terms
- Adolescent, Age Factors, Child, Cross-Sectional Studies, Dental Plaque Index, Diastole, Female, Humans, Hypertension, Male, Obesity, Periodontal Index, Periodontal Pocket, Pilot Projects, Sex Factors, Systole, Thyrotropin, Interleukin-6, Body Mass Index, Interleukin-8, Chemokine CCL2, Leptin
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