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Lactate Is a Major Promotor of Breast Cancer Cell Aggressiveness

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SIRT1/P53 pathway is involved in the Arsenic induced aerobic glycolysis in hepatocytes L-02 cells

Zhang, M., Zhang, Z., Lou, Q., Zhang, X., Yin, F., Yin, Y., Xu, H., Zhang, Y., Fan, C., Gao, Y., et al. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-27570-5 · Cited by 6 · see citing works

UBE2C enhances temozolomide resistance by regulating the expression of p53 to induce aerobic glycolysis in glioma

Zhou, K., Wang, D., Du, X., Feng, X., Zhu, X., & Wang, C. (2024) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2024033 · Cited by 6 · see citing works

Diallyl Trisulfide Enhances Doxorubicin Chemosensitivity by Inhibiting the Warburg Effect and Inducing Apoptosis in Breast Cancer Cells

Chang, C.-M., Wang, W., Mhone, T. G., Ho, W.-K., Chen, C., Ng, S. S.-C., Li, C., Kuo, C., Huang, C., & Kuo, W. (2025) · Journal of Cancer · doi:10.7150/jca.113578 · Cited by 5 · see citing works

p53: An Immune Ecosystem Manipulator

Nian, Z., Dou, Y., & Wei, H. (2025) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-24-3628 · Cited by 4 · see citing works

The SOX12-YBX1-LDHA signaling axis drives metastasis in papillary thyroid carcinoma

Ruan, X., Huang, Y., Zeng, Y., Zhao, Z., Tao, M., Zhao, Z., Wang, Y., Guangwei, X., Zhang, W., Yu, J., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07797-5 · Cited by 3 · see citing works

Flindersine from Haplophyllum tuberculatum modulates glycolysis and promotes apoptosis in breast cancer: Insights from in vitro, electrochemical, and molecular docking studies

Moghtaderi, H., Sadeghian, G., Khan, F., Rehman, N. U., Halim, S. A., Mohammadi, S., Khan, A., Gollahon, L., Al‐Harrasi, A., & Rahman, S. M. (2025) · Pharmacological Research - Natural Products · doi:10.1016/j.prenap.2025.100427 · Cited by 3 · see citing works

Metabolic Vulnerabilities as a Therapeutic Target in Breast Cancer

Guo, S., & Addison, C. (2026) · Current Oncology · doi:10.3390/curroncol33020129 · Cited by 4 · see citing works

Discovery of human lactate dehydrogenase 5 inhibitors (hLDH5) with anti-lung cancer activity through an in silico method and biological validation

He, S., & Wang, Q. (2019) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2019.07.029 · Cited by 3 · see citing works

Targeting mitochondrial bioenergetics by combination treatment with imatinib and dichloroacetate in human erythroleukemic K‑562 and colorectal HCT‑116 cancer cells

Kakafika, M. G., Lyta, A., Gavriilidis, G. I., Tsiftsoglou, S. A., Miliotou, Α. N., Pappas, I. S., Vizirianakis, I. S., Papadopoulou, L. C., & Tsiftsoglou, A. S. (2024) · International Journal of Oncology · doi:10.3892/ijo.2024.5630 · Cited by 2 · see citing works

“Friends or foes”: a new perspective of tumour metabolic transcriptional modification

Shi, T., Geng, Q., Wang, Z., Wen, C., Xu, J., Jiao, Y., Diao, W., Gu, J., Deng, T., Xiao, C., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07429-y · Cited by 1 · see citing works

FBXO39 promotes LDHA-mediated aerobic glycolysis and colorectal cancer progression by p53 degradation

Liu, J., Xiao, T., & Huang, J. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08056-7 · Cited by 1 · see citing works

HRD1 Elicitation of An Anti-Warburg Effect by Targeting PFKP to Inhibit Breast Cancer Growth and ProgressionPreprint

Fan, Y., Wang, J., Xu, Y., Wang, Y., Song, T., Liang, X., Feng, J., & Su, D. (2020) · doi:10.21203/rs.3.rs-42526/v1

Additional file 3 of Anti-Warburg effect by targeting HRD1-PFKP pathway may inhibit breast cancer progression

Fan, Y., Wang, J., Xu, Y., Wang, Y., Song, T., Liang, X., Jin, F., & Su, D. (2021) · Figshare · doi:10.6084/m9.figshare.14037553

Additional file 2 of Anti-Warburg effect by targeting HRD1-PFKP pathway may inhibit breast cancer progression

Fan, Y., Wang, J., Xu, Y., Wang, Y., Song, T., Liang, X., Jin, F., & Su, D. (2021) · Figshare · doi:10.6084/m9.figshare.14037550

Targeting phase separation: a new strategy to disrupt the stromal-immune axis in colorectal cancer

Fu, C., Chen, X., Yi, H., Huang, H.-Y., Zhang, L.-P., Huang, H.-N., Jiang, F., Lei, F., Yu, H.-L., Liu, J.-B., et al. (2026) · Cell Communication and Signaling · doi:10.1186/s12964-026-02849-5

Rethinking residual p53 function in HPV-positive cervical cancer cells

Farrukh, S., Kavčič, N., Canarutto, G., Piazza, S., & Banks, L. (2026) · Journal of Virology · doi:10.1128/jvi.00479-25

BindingDB Entry 50009026: Development of novel human lactate dehydrogenase A inhibitors: High-throughput screening, synthesis, and biological evaluations.

BindingDB (2021) · UC San Diego · doi:10.7270/q2hx1h3h

BindingDB Entry 50010171: Discovery of human lactate dehydrogenase 5 inhibitors (hLDH5) with anti-lung cancer activity through an in silico method and biological validation.

BindingDB (2021) · UC San Diego · doi:10.7270/q2qr51m3

miR-30a-5p suppresses breast tumor growth and metastasis through inhibition of LDHA-mediated Warburg effect

Li, L., Kang, L., Zhao, W., Feng, Y., Liu, W., Wang, T., Mai, H., Huang, J., Chen, S., Liang, Y., et al. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.04.034 · Cited by 205 · see citing works

The miR-34a-LDHA axis regulates glucose metabolism and tumor growth in breast cancer

Xiao, X., Huang, X., Ye, F., Chen, B., Song, C., Wen, J., Zhang, Z., Zheng, G., Tang, H., & Xie, X. (2016) · Scientific Reports · doi:10.1038/srep21735 · Cited by 132 · see citing works

POU1F1 transcription factor induces metabolic reprogramming and breast cancer progression via LDHA regulation

Martínez-Ordóñez, A., Seoane, S., Ávila, L., Eiró, N., Macía, M., Arias, E., Pereira, F., García‐Caballero, T., Gómez‐Lado, N., Aguiar, P., et al. (2021) · Oncogene · doi:10.1038/s41388-021-01740-6 · Cited by 57 · see citing works

p53 Negatively Regulates Transcription of the Pyruvate Dehydrogenase Kinase Pdk2

Contractor, T., & Harris, C. R. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-1215 · Cited by 246 · see citing works

Indole-3-Carbinol Stabilizes p53 to Induce miR-34a, Which Targets LDHA to Block Aerobic Glycolysis in Liver Cancer Cells

Qi, Y., Zhang, C., Wu, D., Zhang, Y., Zhao, Y., & Li, W. (2022) · Pharmaceuticals · doi:10.3390/ph15101257 · Cited by 19 · see citing works