The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Antibiotic Adjuvants: Diverse Strategies for Controlling Drug‐Resistant Pathogens
Open accessAbstract
The growing number of bacterial pathogens that are resistant to numerous antibiotics is a cause for concern around the globe. There have been no new broad‐spectrum antibiotics developed in the last 40 years, and the drugs we have currently are quickly becoming ineffective. In this article, we explore a range of therapeutic strategies that could be employed in conjunction with antibiotics and may help to prolong the life span of these life‐saving drugs. Discussed topics include antiresistance drugs, which are administered to potentiate the effects of current antimicrobials in bacteria where they are no longer (or never were) effective; antivirulence drugs, which are directed against bacterial virulence factors; host‐directed therapies, which modulate the host's immune system to facilitate infection clearance; and alternative treatments, which include such therapies as oral rehydration for diarrhea, phage therapy, and probiotics. All of these avenues show promise for the treatment of bacterial infections and should be further investigated to explore their full potential in the face of a postantibiotic era.
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Cites
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Self-citationProbiotics, prebiotics, and the host microbiome: the science of translation
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Cited by
Quorum sensing signal-response systems in Gram-negative bacteria
Papenfort, K., & Bassler, B. L. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.89 · Cited by 2,256
Drug combinations: a strategy to extend the life of antibiotics in the 21st century
Tyers, M., & Wright, G. D. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0141-x · Cited by 820
Antibiotic resistance breakers: can repurposed drugs fill the antibiotic discovery void?
Brown, D. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4675 · Cited by 359
Borges, A., Abreu, A., Dias, C., Saavedra, M., Borges, F., & Simões, M. (2016) · Molecules · doi:10.3390/molecules21070877 · Cited by 308
Fighting bacterial persistence: Current and emerging anti-persister strategies and therapeutics
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Metadata
- Authors
- Gill, E. E., Franco, O. L., & Hancock, R. E. W.
- Venue
- Chemical Biology & Drug Design
- Publisher
- Wiley
- Published
- 2014-12-17
- Volume
- 85
- Issue
- 1
- Pages
- 56-78
- ISSN
- 1747-0277 (ISSN-L)
- 1747-0285
- OpenAlex
- W2052525877
- Cited by
- 319
- References
- 8
- FWCI
- 9.82
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Gill, E. E., Franco, O. L., & Hancock, R. E. W. (2015). Antibiotic Adjuvants: Diverse Strategies for Controlling Drug‐Resistant Pathogens. Chemical Biology & Drug Design. https://doi.org/10.1111/cbdd.12478
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
