Natural antimicrobial peptides from bacteria: Characteristics and potential applications to fight against antibiotic resistance
Abstract
Because of the emergence of antibiotic-resistant pathogens worldwide, a number of infectious diseases have become difficult to treat. This threatening situation is worsened by the fact that very limited progress has been made in developing new and potent antibiotics in recent years. However, a group of antimicrobials, the so-called bacteriocins, have been much studied lately because they hold a great potential in controlling antibiotic-resistant pathogens. Bacteriocins are small antimicrobial peptides (AMPs) produced by numerous bacteria. They often act toward species related to the producer with a very high potency (at pico- to nanomolar concentration) and specificity. The common mechanisms of killing by bacteriocins are destruction of target cells by pore formation and/or inhibition of cell wall synthesis. Several studies have revealed that bacteriocins display great potential in the medical sector as bacteriocinogenic probiotics and in the clinic as therapeutic agents. In this review, we discuss the emerging antibiotic resistance and strategies to control its dissemination, before we highlight the potential of AMPs from bacteria as a new genre of antimicrobial agents.
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The most common mechanisms used by bacteriocins to kill other microorganisms include the formation of pores in the cell membrane or the inhibition of cell wall synthesis.
“The most common mechanisms used by bacteriocins to kill other microorganisms include the formation of pores in the cell membrane or the inhibition of cell wall synthesis [186].”
From Lactic Acid Bacteria in Raw-Milk Cheeses: From Starter Cultures to Probiotic Functions (2022) · cites this paper as [186]
Several studies have shown that the use of bacteriocin-producing bacteria is more effective than purified bacteriocins in improving gut health.
“Several studies have shown that the use of bacteriocin-producing bacteria is more effective than purified bacteriocins in improving gut health [186].”
From Lactic Acid Bacteria in Raw-Milk Cheeses: From Starter Cultures to Probiotic Functions (2022) · cites this paper as [186]
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- Authors
- Hassan, M., Kjos, M., Nes, I. F., Diep, D. B., & Lotfipour, F.
- Affiliations
- Zanjan University of Medical Sciences (IR)
- Norwegian University of Life Sciences (NO)
- Tabriz University of Medical Sciences (IR)
- Corresponding author
- Lotfipour, F.
- Venue
- Journal of Applied Microbiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-06-08
- Volume
- 113
- Issue
- 4
- Pages
- 723-736
- ISSN
- 1364-5072 (ISSN-L)
- OpenAlex
- W2132437761
- Cited by
- 402
- References
- 135
- Citations by year
- 2026: 13 · 2025: 19 · 2024: 32 · 2023: 32 · 2022: 42 · 2021: 35 · 2020: 45 · 2019: 34 · 2018: 29 · 2017: 29 · 2016: 23 · 2015: 28 · 2014: 21 · 2013: 13 · 2012: 7
- FWCI
- 3.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- World Health Organization
- National Institute of Allergy and Infectious Diseases
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- antimicrobial peptides, bacteriocins, antibiotic resistance, antibiotic-resistant pathogens, pore formation, cell wall synthesis inhibition, natural antimicrobials
- MeSH terms
- Bacteria, Bacteriocins, Peptides, Probiotics, Drug Resistance, Bacterial
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