The role of obesity and type 2 diabetes mellitus in the development of male obesity‐associated secondary hypogonadism
Open accessAbstract
Summary: Obesity, secondary (hypogonadotrophic) hypogonadism (SH), sleep disorders [such as obstructive sleep apnoea (OSA)] and type 2 diabetes mellitus (T2DM) in men have complex interlinks both with respect to mutual aetiopathogenesis as well as therapeutics. Correction of the attendant hypogonadism in obese men may serve to break this link and have beneficial effects beyond restoration of normal sexual function. Male obesity‐associated secondary hypogonadism (MOSH) should be regarded as a distinct clinical entity and subtype of SH. A high index of suspicion for the presence of MOSH must be maintained by clinicians when assessing obese men. The pathogenesis of MOSH remains incompletely understood. Furthermore, the optimal management of MOSH and its associated sequelae will require long‐term prospective studies that in turn will inform the development of future clinical guidelines for this important and prevalent condition.
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A further mechanism contributing to SO, at least in men, is increased aromatase expression within adipocytes in the context of excessive adiposity.
“a further mechanism that contributes towards the development of SO, at least in men, is the increased aromatase expression that occurs within adipocytes in the context of excessive adiposity.”
From Optimised Skeletal Muscle Mass as a Key Strategy for Obesity Management (2025) · cites this paper as [76]
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Self-citation
- Authors
- Saboor Aftab, S. A., Kumar, S., & Barber, T. M.
- Affiliations
- Clinical Sciences Research Laboratories Division of Metabolic and Vascular Health Warwick Medical School The University of Warwick Clinical Sciences Building University Hospitals Coventry and Warwickshire Coventry UK
- University Hospitals Coventry and Warwickshire NHS Trust (GB)
- Corresponding author
- Barber, T. M.
- Venue
- Clinical Endocrinology
- Publisher
- Wiley
- Published
- 2013-01-25
- Volume
- 78
- Issue
- 3
- Pages
- 330-337
- ISSN
- 0300-0664 (ISSN-L)
- 1365-2265
- OpenAlex
- W1975704047
- Cited by
- 157
- References
- 15
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 10 · 2023: 12 · 2022: 20 · 2021: 14 · 2020: 14 · 2019: 17 · 2018: 15 · 2017: 10 · 2016: 4 · 2015: 9 · 2014: 8 · 2013: 7
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Keywords
- secondary hypogonadism, obesity, type 2 diabetes, obstructive sleep apnea, male hypogonadism, sexual function, pathogenesis
- MeSH terms
- Diabetes Mellitus, Type 2, Humans, Hypogonadism, Male, Obesity, Sleep Apnea, Obstructive
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