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Cited by 318Hormonal and reproductive studiesDiabetes, Cardiovascular Risks, and LipoproteinsSperm and Testicular Function

Androgens, insulin resistance and vascular disease in men

Kapoor, D., Malkin, C. J., Channer, K. S., Jones, T. H.·2005·Clinical Endocrinology
DOI 10.1111/j.1365-2265.2005.02299.x
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Abstract

Summary: Type 2 diabetes mellitus is increasing globally and is an established risk factor for the development of atherosclerotic vascular disease. Insulin resistance is the hallmark feature of type 2 diabetes and is also an important component of the metabolic syndrome. There is evidence to suggest that testosterone is an important regulator of insulin sensitivity in men. Observational studies have shown that testosterone levels are low in men with diabetes, visceral obesity (which is strongly associated with insulin resistance), coronary artery disease and metabolic syndrome. Short‐term interventional studies have also demonstrated that testosterone replacement therapy produces an improvement in insulin sensitivity in men. Thus hypotestosteronaemia may have a role in the pathogenesis of insulin‐resistant states and androgen replacement therapy could be a potential treatment that could be offered for improvements in glycaemic control and reduction in cardiovascular risk, particularly in diabetic men.

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Crossref · 10.1111/j.1365-2265.2005.02299.x

Cites

120 of 120 references verified0 citation errors · 0 not checkable

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Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Tobacco consumption exerts effects on adrenal androgen secretion; high levels of androstenedione and dehydroepiandrosterone sulfate are usually found in smokers.

    “In addition, tobacco consumption has also been shown to exert effects on adrenal androgen secretion; in fact, high levels of androstenedione and dehydropiandrosterone sulfate (DHEAS) are usually found in smokers [40].”

    From Skeletal System Biology and Smoke Damage: From Basic Science to Medical Clinic (2021) · cites this paper as [40]

  • Increased release of cortisol into the circulation due to an upstream increase in ACTH could represent a causal indirect effect of smoking contributing to reduced bone mineral density, because increased circulating cortisol correlates with increased osteoporosis risk.

    “As increased high levels of circulating cortisol correlate with an increased risk of osteoporosis, this could represent a causal indirect effect of smoking contributing to the reduction of BMD [40,41].”

    From Skeletal System Biology and Smoke Damage: From Basic Science to Medical Clinic (2021) · cites this paper as [40]

  • Low testosterone levels in men are associated with reduced insulin sensitivity and type 2 diabetes.

    “It is being increasingly recognized that low testosterone levels in men are associated with reduced insulin sensitivity and type 2 diabetes (1).”

    From Clinical and Biochemical Assessment of Hypogonadism in Men With Type 2 Diabetes (2007) · cites this paper as [1]

  • There is increased deposition of abdominal adipose tissue in hypogonadal subjects, which leads to a further decrease in testosterone concentrations through conversion to estradiol by aromatase.

    “There is increased deposition of abdominal adipose tissue in hypogonadal subjects, which in turn leads to a further decrease in testosterone concentrations, through conversion to estradiol by aromatase.”

    From Clinical and Biochemical Assessment of Hypogonadism in Men With Type 2 Diabetes (2007) · cites this paper as [1]

  • Studies of testosterone in non-heart-failure males suggest that physiological testosterone therapy improves insulin sensitivity.

    “Studies of testosterone in non-(CHF) males suggest that physiological testosterone therapy improves insulin sensitivity.”

    From The Effect of Testosterone on Insulin Sensitivity in Men with Heart Failure (2007) · cites this paper as [10]

Cites

Flagged first, then by citations

Research works printed but not linked: 10

  1. 10.1080/713602987 · DOI
  2. 10.1210/jc.85.9.3276 · DOI
  3. 10.1210/jc.76.2.279 · DOI
  4. 10.1210/jc.79.1.265 · DOI
  5. Thaddea S., 1940, The effect of the sex hormones on metabolism in diabetes of late onset, Klinicheskaia Meditsina, 137, 760
  6. 10.1210/jc.74.2.362 · DOI
  7. 10.1210/jc.80.11.3373 · DOI
  8. 10.1080/713604785 · DOI
  9. Rayner M., 1998, British Heart Foundation Statistics Database
  10. Pugh P.J., 2003, High prevalence of low testosterone levels in men with coronary heart disease and an association with hypertension and obesity, Endocrine Abstracts, 5, P225

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Authors
Kapoor, D., Malkin, C. J., Channer, K. S., & Jones, T. H.
Affiliations
  • Barnsley Hospital NHS Foundation Trust (GB)
  • Royal Hallamshire Hospital (GB)
Corresponding author
Jones, T. H.
ORCID
Jones, T. H.
Venue
Clinical Endocrinology
Publisher
Wiley
Published
2005-06-15
Volume
63
Issue
3
Pages
239-250
ISSN
  • 0300-0664 (ISSN-L)
  • 1365-2265
DOI
10.1111/j.1365-2265.2005.02299.x
OpenAlex
W2137783284
Cited by
317
References
120
Citations by year
2026: 3 · 2025: 6 · 2024: 13 · 2023: 8 · 2022: 8 · 2021: 11 · 2020: 10 · 2019: 7 · 2018: 12 · 2017: 8 · 2016: 10 · 2015: 16 · 2014: 23 · 2013: 13 · 2012: 23
FWCI
3.27
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Clinical Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Keywords
androgens, testosterone, insulin resistance, type 2 diabetes, atherosclerosis, coronary artery disease, metabolic syndrome, visceral obesity, hypogonadism, testosterone replacement therapy, glycemic control, cardiovascular risk, men
MeSH terms
Aged, Aging, Arteriosclerosis, Dehydroepiandrosterone, Diabetes Mellitus, Type 2, Humans, Insulin Resistance, Male, Middle Aged, Obesity, Sex Hormone-Binding Globulin, Testosterone, Vascular Diseases

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