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Cited by 128Hormonal and reproductive studiesDiabetes, Cardiovascular Risks, and LipoproteinsSperm and Testicular Function

Lower serum testosterone is independently associated with insulin resistance in non-diabetic older men: the Health In Men Study

Yeap, Bu B, Chubb, S A Paul, Hyde, Zoë, Jamrozik, Konrad, Hankey, Graeme J, Flicker, Leon, Norman, Paul E·2009·European Journal of Endocrinology
DOI 10.1530/eje-09-0348
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Abstract

OBJECTIVE: Insulin resistance is associated with metabolic syndrome and type 2 diabetes, representing a risk factor for cardiovascular disease. This relationship may be modulated to some extent by age-related changes in sex hormone status. We examined whether lower testosterone or sex hormone-binding globulin (SHBG) levels in older men are associated with insulin resistance independently of measures of central obesity. DESIGN: Cross-sectional analysis of 2470 community-dwelling non-diabetic men aged > or = 70 years. METHODS: Age, body mass index (BMI) and waist circumference were measured. Early morning sera were assayed for total testosterone, SHBG, LH and insulin levels. Free testosterone was calculated using mass action equations, and insulin resistance was assessed using a homeostatic model (HOMA2-IR). RESULTS: Total testosterone, free testosterone and SHBG declined progressively across increasing quintiles of HOMA2-IR (all P<0.001) and correlated inversely with log HOMA2-IR (r=-0.27, -0.14 and -0.24 respectively, all P<0.001). After adjusting for age, BMI, waist circumference, high-density lipoprotein and triglyceride levels, total testosterone was independently associated with log HOMA2-IR (beta=0.05, P<0.001), while SHBG was not. Serum total testosterone <8 nmol/l was associated with HOMA2-IR in the highest quintile (odds ratio (OR) 1.67, 95% confidence interval (CI) 1.02-2.73) as was total testosterone > or = 8 and <15 nmol/l (OR 1.29, 95% CI 1.03-1.63). CONCLUSIONS: In older men, lower total testosterone is associated with insulin resistance independently of measures of central obesity. This association is seen with testosterone levels in the low to normal range. Further studies are needed to evaluate interventions that raise testosterone levels in men with reduced insulin sensitivity.

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Crossref · 10.1530/eje-09-0348

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  • In elderly men, lower testosterone levels are associated with reduced insulin sensitivity as indicated by higher glucose during an oral glucose tolerance test, reduced QUICKI score, and lower HOMA-IR values.

    “In elderly men, lower T levels are associated with reduced insulin sensitivity as indicated by higher glucose levels during an oral glucose tolerance test,71 reduced quantitative insulin sensitivity check index score,93, 94 and lower HOMA-IR values.95”

    From Hormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications (2021) · cites this paper as [95]

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Authors
Yeap, B. B., Chubb, S. A. P., Hyde, Z., Jamrozik, K., Hankey, G. J., Flicker, L., & Norman, P. E.
Affiliations
  • The University of Western Australia (AU)
  • The University of Adelaide (AU)
Corresponding author
Yeap, Bu B
ORCID
Venue
European Journal of Endocrinology
Publisher
Oxford University Press (OUP)
Published
2009-10
Volume
161
Issue
4
Pages
591-598
ISSN
  • 0804-4643 (ISSN-L)
  • 1479-683X
DOI
10.1530/eje-09-0348
OpenAlex
W2151358666
Cited by
128
References
41
Citations by year
2026: 3 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 5 · 2021: 3 · 2020: 10 · 2019: 4 · 2018: 5 · 2017: 13 · 2016: 5 · 2015: 11 · 2014: 9 · 2013: 12 · 2012: 11
FWCI
9.21
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • UWA Profiles and Research Repository (UWA) (submittedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Keywords
insulin resistance, total testosterone, sex hormone-binding globulin, older men, HOMA2-IR, abdominal obesity, sex hormones, metabolic syndrome, testosterone replacement therapy, Health in Men Study
MeSH terms
Aged, Anthropometry, Cross-Sectional Studies, Health, Humans, Insulin, Insulin Resistance, Luteinizing Hormone, Lipoproteins, Male, Obesity, Sex Hormone-Binding Globulin, Gonadal Steroid Hormones, Testosterone, Western Australia, Body Mass Index, Multivariate Analysis, Adiposity

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