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Cited by 21Genetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesGrowth Hormone and Insulin-like Growth FactorsSexual Differentiation and Disorders

Weight gain in Turner syndrome: association to puberty induction?—longitudinal analysis of KIGS data

Reinehr, Thomas, Lindberg, Anders, Toschke, Christina, Cara, Jose, Chrysis, Dionisis, Camacho‐Hübner, Cecilia·2016·Clinical Endocrinology
DOI 10.1111/cen.13044
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Abstract

CONTEXT: Girls with Turner Syndrome (TS) treated or not treated with growth hormone (GH) are prone to overweight. Therefore, we hypothesize that puberty induction in TS is associated with weight gain. METHODS: We analyzed weight changes (BMI-SDS) between onset of GH treatment and near adult height (NAH) in 887 girls with TS enrolled in KIGS (Pfizer International Growth Database). Puberty was induced with estrogens in 646 (72·8%) girls with TS. RESULTS: Weight status did not change significantly between GH treatment start and 1 year later (mean difference -0·02 BMI-SDS), but increased significantly (P < 0·001) until NAH (+0·40 BMI-SDS). The BMI-SDS increased +0·21 until start of puberty (P < 0·001). Girls with spontaneous and induced puberty showed similar BMI-SDS changes. Puberty induction at ≥12 years was associated with a significant (P < 0·001) less increase of BMI-SDS (+0·7 BMI-SDS) between baseline and NAH compared to puberty induction at <12 year (+1·0 BMI-SDS). In multiple linear regression analyses changes of BMI-SDS between baseline and NAH were negatively associated with baseline BMI-SDS (P < 0·001), GH doses (P = 0·015), and age at puberty induction (P < 0·001), positively with years on GH treatment (P = 0·004), while duration and dose of estrogens, its route of administration (transdermal/oral), changes of height-SDS, thyroxin and oxandrolone treatment, and karyotype did not correlate significantly to changes of BMI-SDS in this time period. CONCLUSIONS: Puberty does not seem to play a major role in weight gain in girls with TS since the majority of the increases in BMI-SDS occurred before puberty. However, late puberty induction seems to decrease the risk of weight gain.

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Crossref · 10.1111/cen.13044

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  • TD vs oral HRT shows no significant differences in protein turnover, lipolysis, osteocalcin, C-reactive protein, BMI, or waist-to-hip ratio.

    “TD vs oral HRT: no significant differences in protein turnover, lipolysis, osteocalcin, C-reactive protein, BMI, or waist-to-hip ratio”

    From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [379]

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Authors
Reinehr, T., Lindberg, A., Toschke, C., Cara, J., Chrysis, D., & Camacho‐Hübner, C.
Affiliations
  • Witten/Herdecke University (DE)
  • Pfizer (Sweden) (SE)
  • Pfizer (United States) (US)
  • University of Patras (GR)
Corresponding author
Reinehr, Thomas
ORCID
Venue
Clinical Endocrinology
Publisher
Wiley
Published
2016-03-18
Volume
85
Issue
1
Pages
85-91
ISSN
  • 0300-0664 (ISSN-L)
  • 1365-2265
DOI
10.1111/cen.13044
OpenAlex
W2281981874
Cited by
21
References
36
Citations by year
2024: 3 · 2023: 1 · 2022: 4 · 2020: 3 · 2019: 2 · 2018: 4 · 2017: 4
FWCI
2.69
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Clinical Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
Keywords
Turner syndrome, weight gain, puberty induction, growth hormone therapy, body mass index, estrogen therapy, near-adult height, childhood obesity
MeSH terms
Body Height, Child, Estrogens, Female, Humans, Longitudinal Studies, Puberty, Growth Hormone, Turner Syndrome, Weight Gain

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