Cited by 9Neurotransmitter Receptor Influence on BehaviorMemory and Neural MechanismsNeuropeptides and Animal Physiology

The caudal part of the posterior insula of rats participates in the maintenance but not the acquisition of morphine conditioned place preference

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Sun, Yong‐Mei, Chen, Rong‐Xiang, Li, Zhi‐Fei, Spijker, Sabine, Zhai, Rong‐Wei, Yang, Shang‐Chuan·2018·CNS Neuroscience & Therapeutics

Abstract

The heterogeneous insular cortex plays an interoceptive role in drug addiction by signaling the availability of drugs of abuse. Here, we tested whether the caudal part of the multisensory posterior insula (PI) stores somatosensory-associated rewarding memories. Using Sprague Dawley rats as subjects, we first established a morphine-induced conditioned place preference (CPP) paradigm, mainly based on somatic cues. Secondly, an electrolytic lesion of the caudal portion of the PI was carried out before and after the establishment of CPP, respectively. Our data demonstrated that the caudal PI lesions disrupted the maintenance, but not the acquisition of morphine-induced CPP. Lesion or subtle disruption of the PI had no major impact on locomotor activity. These findings indicate that the caudal portion of the PI might be involved in either the storage or the retrieval of morphine CPP memory.

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Authors
Sun, Y., Chen, R., Li, Z., Spijker, S., Zhai, R., & Yang, S.
Affiliations
  • Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of Zoology Chinese Academy of Sciences Kunming China
  • Chinese Academy of Sciences (CN)
  • Amsterdam Neuroscience (NL)
Venue
CNS Neuroscience & Therapeutics
Publisher
Wiley
Published
2018-01-09
Volume
24
Issue
5
Pages
420-428
ISSN
  • 1755-5930 (ISSN-L)
  • 1755-5949
OpenAlex
W2784330440
Cited by
9
References
37
Citations by year
2024: 2 · 2023: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 2
FWCI
0.68
Type
journal article
Language
en
Open access
Locations
  • CNS Neuroscience & Therapeutics (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • VU Research Portal (submittedVersion, other-oa)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
morphine, conditioned place preference, drug addiction, memory retrieval, memory storage, somatosensory cues, interoception, insula, electrolytic lesions, locomotor activity
MeSH terms
Animals, Cerebral Cortex, Conditioning, Psychological, Male, Memory, Morphine, Motor Activity, Narcotics, Spatial Behavior, Rats, Sprague-Dawley

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