The caudal part of the posterior insula of rats participates in the maintenance but not the acquisition of morphine conditioned place preference
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The heterogeneous insular cortex plays an interoceptive role in drug addiction by signaling the availability of drugs of abuse. Here, we tested whether the caudal part of the multisensory posterior insula (PI) stores somatosensory-associated rewarding memories. Using Sprague Dawley rats as subjects, we first established a morphine-induced conditioned place preference (CPP) paradigm, mainly based on somatic cues. Secondly, an electrolytic lesion of the caudal portion of the PI was carried out before and after the establishment of CPP, respectively. Our data demonstrated that the caudal PI lesions disrupted the maintenance, but not the acquisition of morphine-induced CPP. Lesion or subtle disruption of the PI had no major impact on locomotor activity. These findings indicate that the caudal portion of the PI might be involved in either the storage or the retrieval of morphine CPP memory.
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Lesions of the aIC or pIC both produce no effect on the acquisition of morphine-induced CPP.
“Lesions of the aIC or pIC both produce no effect on the acquisition of morphine-induced CPP”
From The Insula: A Brain Stimulation Target for the Treatment of Addiction (2019) · cites this paper as Sun et al., 2018
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- Authors
- Sun, Y., Chen, R., Li, Z., Spijker, S., Zhai, R., & Yang, S.
- Affiliations
- Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of Zoology Chinese Academy of Sciences Kunming China
- Chinese Academy of Sciences (CN)
- Amsterdam Neuroscience (NL)
- Venue
- CNS Neuroscience & Therapeutics
- Publisher
- Wiley
- Published
- 2018-01-09
- Volume
- 24
- Issue
- 5
- Pages
- 420-428
- ISSN
- 1755-5930 (ISSN-L)
- 1755-5949
- PMC
- PMC5947672
- OpenAlex
- W2784330440
- Cited by
- 9
- References
- 37
- Citations by year
- 2024: 2 · 2023: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 2
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- CNS Neuroscience & Therapeutics (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- VU Research Portal (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- morphine, conditioned place preference, drug addiction, memory retrieval, memory storage, somatosensory cues, interoception, insula, electrolytic lesions, locomotor activity
- MeSH terms
- Animals, Cerebral Cortex, Conditioning, Psychological, Male, Memory, Morphine, Motor Activity, Narcotics, Spatial Behavior, Rats, Sprague-Dawley
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