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Cited by 35Vestibular and auditory disordersHearing, Cochlea, Tinnitus, GeneticsAcute Ischemic Stroke Management

Spontaneous recovery rate of idiopathic sudden sensorineural hearing loss: A systematic review and meta‐analysis

Chaushu, Hen, Ungar, Omer J., Abu Eta, Rani, Handzel, Ophir, Muhanna, Nidal, Oron, Yahav·2023·Clinical Otolaryngology
DOI 10.1111/coa.14036
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Abstract

Purpose: Steroids comprise the mainstay of treatment for idiopathic sudden sensorineural hearing loss (ISSNHL). Since steroidal treatment was integrated to clinical practice guidelines, newly published no‐treatment or placebo arms in clinical trials are scarce. To evaluate the effectiveness of steroidal treatment ± hyperbaric oxygen therapy, the data should be compared to spontaneous recovery. The aim of this paper is to find the most accurate spontaneous recovery rate, in the light of which, other treatment modalities should be judged. Materials and Methods: Eligible studies published until July 2021 were identified through systematic searches of ‘PubMed’, ‘Web of Science’ and ‘Google Scholar’. Retrospective studies and randomised/non‐randomised control trials involving only adult participants (≥18 years) with ISSNHL, and placebo/no treatment were included. Only articles that used the American Academy of Otolaryngology–Head and Neck Surgery's diagnostic criteria for ISSNHL were included. Results: 942 records initially identified, 166 duplicates and 753 articles were excluded based on article subject, title, and abstract. The full texts of 13 articles were reviewed. Seven studies were included for qualitative synthesis, five papers included in quantitative synthesis. 180 ears were included in pooled statistics. The pooled spontaneous recovery was 60.28% (95% confidence interval [CI] = 38.88%–79.94%) with a heterogeneity of 86.0% (95% CI = 69.4%–93.6%). Conclusions: Spontaneous recovery of ISSNHL should not be over‐looked, as it may be close to 60%. This may have both clinical and research implications.

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Crossref · 10.1111/coa.14036

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17 of 17 references verified0 citation errors · 0 not checkable

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Research works printed but not linked: 1

  1. National Institute on Deafness and Other Communication Disorders, 2018, NIDCD Fact Sheet: Sudden Deafness

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Authors
Chaushu, H., Ungar, O. J., Abu Eta, R., Handzel, O., Muhanna, N., & Oron, Y.
Affiliations
  • Tel Aviv University (IL)
  • Department of Otolaryngology Head and Neck Surgery and Maxillofacial Surgery Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, affiliated to the Sackler School of Medicine, Tel Aviv University Tel Aviv Israel
Corresponding author
  • Chaushu, Hen
  • Ungar, Omer J.
ORCID
Venue
Clinical Otolaryngology
Publisher
Wiley
Published
2023-01-22
Volume
48
Issue
3
Pages
395-402
ISSN
  • 0307-7772 (ISSN-L)
  • 1749-4478
  • 1749-4486
DOI
10.1111/coa.14036
OpenAlex
W4316174570
Semantic Scholar
f65f0983b0002e49366839e07ae5f681f1787de5
Cited by
35
References
17
Citations by year
2026: 6 · 2025: 15 · 2024: 7 · 2023: 7
FWCI
1.43
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Clinical Otolaryngology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
  • Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
  • Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
Keywords
idiopathic sudden sensorineural hearing loss, spontaneous recovery, corticosteroid therapy, hyperbaric oxygen therapy, treatment effectiveness
MeSH terms
Adult, Hearing Loss, Sudden, Glucocorticoids, Hearing Loss, Sensorineural, Humans, Retrospective Studies, Steroids

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