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Cited by 316

The DOI matches its Crossref record; 94 of the 94 references it cites were found in a registry or an index.

Nickel allergy and allergic contact dermatitis: A clinical review of immunology, epidemiology, exposure, and treatment

Ahlström, Malin G., Thyssen, Jacob P., Wennervaldt, Michael, Menné, Torkil, Johansen, Jeanne D.·2019·Contact Dermatitis
DOI 10.1111/cod.13327
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Abstract

Nickel is the most frequent cause of contact allergy worldwide and has been studied extensively. This clinical review provides an updated overview of the epidemiology, exposure sources, methods for exposure quantification, skin deposition and penetration, immunology, diagnosis, thresholds for sensitization and elicitation, clinical pictures, prevention, and treatment. The implementation of a nickel regulation in Europe led to a decrease in the prevalence of nickel allergy, and changes in the clinical picture and disease severity. Nevertheless, the prevalences of nickel allergy in the European general population are approximately 8% to 19% in adults and 8% to 10% in children and adolescents, with a strong female predominance. Well‐known consumer items such as jewellery and metal in clothing are still the main causes of nickel allergy and dermatitis, although a wide range of items for both private and occupational use may cause dermatitis. Allergic nickel dermatitis may be localized to the nickel exposure site, be more widespread, or present as hand eczema. Today, efficient methods for exposure quantification exist, and new insights regarding associated risk factors and immunological mechanisms underlying the disease have been obtained. Nevertheless, questions remain in relation to the pathogenesis, the persistent high prevalence, and the treatment of severe cases.

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Metadata

Authors
Ahlström, M. G., Thyssen, J. P., Wennervaldt, M., Menné, T., & Johansen, J. D.
Venue
Contact Dermatitis
Publisher
Wiley
Published
2019-07-09
Volume
81
Issue
4
Pages
227-241
ISSN
  • 0105-1873 (ISSN-L)
  • 1600-0536
DOI
10.1111/cod.13327
OpenAlex
W2947126976
Cited by
316
References
94
FWCI
29.00
Type
journal article
Language
en
Open access
closed

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.