Association between duration and quality of sleep and the risk of pre‐diabetes: evidence from NHANES
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AIMS: To examine the association between duration and quality of sleep and the prevalence of undiagnosed and clinically identified diabetes mellitus and pre-diabetes in a nationally representative sample. METHODS: Cross-sectional study of 2285 participants ≥ 30 years old and without diagnosed sleep disorders from the National Health and Nutrition Examination Survey (2005-2008). The primary exposures were sleep duration and quality. Sleep quality was assessed by questionnaire using trouble initiating sleep, trouble maintaining sleep, and waking up too early. The primary outcomes were clinically identified and undiagnosed pre-diabetes and diabetes as defined by the American Diabetes Association using fasting plasma glucose (5.6-6.9 mmol/l = pre-diabetes; ≥ 7.0 mmol/l = diabetes). Multivariate logistic regression was used to test the association between sleep quality, sleep duration and glycaemic status. RESULTS: After adjustment for socio-demographic characteristics and health behaviors, sleeping ≤ 5 h/night was associated with clinically identified pre-diabetes (odds ratio 2.06, 95% CI 1.00-4.22 vs. 7 h). Both trouble maintaining sleep ≥ 5 times/month (odds ratio 3.50, 95% CI 1.30-9.45) and waking up too early ≥ 5 times/month (odds ratio 2.69, 95% CI 1.21-5.98) were also significantly associated with increased risk of clinically identified pre-diabetes. Trouble initiating sleep and sleeping ≥ 9 h/night were not found to be associated with having diabetes. CONCLUSIONS: Only clinically identified pre-diabetes was associated with trouble maintaining sleep, waking up too early, and short sleep. No other relations were found to be significant. Findings suggest that poor sleep quality and short sleep duration were more strongly associated with clinically identified pre-diabetes than 7-8 hours per day.
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Sleep ≤5-h is associated with clinically identified pre-diabetes in NHANES.
“The analysis from the NHANES study showed association between sleep ≤5-h and clinically identified pre-diabetes [13].”
From Metabolic effects of sleep disruption, links to obesity and diabetes (2014) · cites this paper as [13]
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- Authors
- Engeda, J., Mezuk, B., Ratliff, S., & Ning, Y.
- Affiliations
- Virginia Commonwealth University (US)
- Corresponding author
- Ning, Y.
- Venue
- Diabetic Medicine
- Publisher
- Wiley
- Published
- 2013-03-22
- Volume
- 30
- Issue
- 6
- Pages
- 676-680
- ISSN
- 0742-3071 (ISSN-L)
- 1464-5491
- PMC
- PMC3660430
- OpenAlex
- W2021253165
- Cited by
- 110
- References
- 14
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 7 · 2023: 13 · 2022: 8 · 2021: 6 · 2020: 9 · 2019: 8 · 2018: 9 · 2017: 6 · 2016: 10 · 2015: 11 · 2014: 8 · 2013: 5
- FWCI
- 15.35
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Diabetic Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (T32HL007055)
- National Institute of Mental Health (K01-MH093642-A1, K01MH093642)
- National Institute of General Medical Sciences (R25GM089614)
- National Institute of Diabetes and Digestive and Kidney Diseases (R21DK096375)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- sleep duration, sleep quality, prediabetes, diabetes mellitus, short sleep duration, glycemic status, undiagnosed diabetes, NHANES
- MeSH terms
- Adult, Aged, Aged, 80 and over, Blood Glucose, Cross-Sectional Studies, Diabetes Mellitus, Female, Health Surveys, Humans, Sleep Initiation and Maintenance Disorders, Male, Middle Aged, Prediabetic State, Risk, United States, Prevalence, Logistic Models, Self Report
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