Effects of intranasal insulin on endogenous glucose production in insulin‐resistant men
Abstract
The effects of intranasal insulin on the regulation of endogenous glucose production (EGP) in individuals with insulin resistance were assessed in a single‐blind, crossover study. Overweight or obese insulin‐resistant men ( n = 7; body mass index 35.4 ± 4.4 kg/m 2 , homeostatic model assessment of insulin resistance 5.6 ± 1.6) received intranasal spray of either 40 IU insulin lispro or placebo in 2 randomized visits. Acute systemic spillover of intranasal insulin into the circulation was matched with a 30‐minute intravenous infusion of insulin lispro in the nasal placebo arm. EGP was assessed under conditions of a pancreatic clamp with a primed, constant infusion of glucose tracer. Under these experimental conditions, compared with placebo, intranasal administration of insulin did not significantly affect plasma glucose concentrations, EGP or glucose disposal in overweight/obese, insulin‐resistant men, in contrast to our previous study, in which an equivalent dose of intranasal insulin significantly suppressed EGP in lean, insulin‐sensitive men. Insulin resistance is probably associated with impairment in centrally mediated insulin suppression of EGP.
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In pancreatic clamps with a primed, constant infusion of glucose tracers, IN administration of 40 IU insulin lispro compared with placebo suppressed endogenous glucose production only in normal-weight participants.
“In the latter set of experiments, 83,84 the IN administration of 40 IU of insulin lispro, another rapid-acting insulin analogue, in comparison with placebo, suppressed endogenous glucose production only in the normal-weight participants.”
From Intranasal insulin (2021) · cites this paper as [84]
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- Authors
- Xiao, C., Dash, S., Stahel, P., & Lewis, G. F.
- Affiliations
- University of Toronto (CA)
- Corresponding author
- Lewis, Gary F.
- Venue
- Diabetes, Obesity and Metabolism
- Publisher
- Wiley
- Published
- 2018-04-14
- Volume
- 20
- Issue
- 7
- Pages
- 1751-1754
- ISSN
- 1462-8902 (ISSN-L)
- 1463-1326
- OpenAlex
- W2792803451
- Cited by
- 19
- References
- 15
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 1
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Obesity and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Diabetes Canada
- Drucker Family Chair in Diabetes Research
- Sun Life Financial Chair in Diabetes
- Banting and Best Diabetes Centre Hugh Sellers Postdoctoral Fellowship and a Diabetes Action Canada Postdoctoral Fellowship
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- intranasal insulin, endogenous glucose production, insulin resistance, insulin lispro, glucose disposal, obesity, overweight men, glucose tracer
- MeSH terms
- Administration, Intranasal, Adult, Blood Glucose, Gluconeogenesis, Humans, Hypoglycemic Agents, Insulin, Insulin Resistance, Male, Middle Aged, Obesity, Glucose Clamp Technique, Single-Blind Method, Cross-Over Studies, Overweight, Insulin Lispro
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