Nasal insulin administration does not affect hepatic glucose production at systemic fasting insulin levels
Open accessAbstract
Aims: To evaluate the effects of brain insulin on endogenous glucose production in fasting humans, with a focus on hepatic glucose release by performing a randomized, placebo‐controlled, blinded, crossover experiment. Materials and methods: On two separate days, 2 H 2 ‐glucose was infused to nine healthy lean men, and blood was sampled from the hepatic vein and a radial artery. On day 1, participants received 160 U human insulin through nasal spray, and on day 2 they received placebo spray, together with an intravenous insulin bolus to mimic spillover of nasal insulin to the circulation. Hepatic glucose fluxes and endogenous glucose production were calculated. Results: Plasma insulin concentrations were similar on the two study days, and no differences in whole‐body endogenous glucose production or hepato‐splanchnic glucose turnover were detected. Conclusions: Nasal administration of insulin does not influence whole‐body or hepatic glucose production in fasting humans. By contrast, pharmacological delivery of insulin to the brain might modulate insulin effectiveness in glucose‐producing tissue when circulating insulin levels are elevated; therefore, the metabolic consequences of brain insulin action appear to be dependent on metabolic prandial status.
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Brain insulin action may require postprandial metabolic conditions.
“However, this may require postprandial metabolic conditions12,13”
From Brain insulin action on peripheral insulin sensitivity in women depends on menstrual cycle phase (2023) · cites this paper as [12]
Nasal insulin did not modulate endogenous glucose production under systemic fasting insulin concentrations in most clinical trials.
“as nasal insulin did not modulate endogenous glucose production under systemic fasting insulin concentrations in most12,14, but not all, clinical trials11.”
From Brain insulin action on peripheral insulin sensitivity in women depends on menstrual cycle phase (2023) · cites this paper as [12]
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- Authors
- Plomgaard, P., Hansen, J. S., Ingerslev, B., Clemmesen, J. O., Secher, N. H., van Hall, G., Fritsche, A., Weigert, C., Lehmann, R., Häring, H., & Heni, M.
- Affiliations
- University of Copenhagen (DK)
- Copenhagen University Hospital (DK)
- Department of Biomedical Sciences Clinical Metabolomics Core Facility, Clinical Biochemistry, Rigshospitalet Copenhagen Denmark
- Helmholtz Munich (DE)
- Corresponding author
- Plomgaard, Peter
- ORCID
- Venue
- Diabetes, Obesity and Metabolism
- Publisher
- Wiley
- Published
- 2019-01-17
- Volume
- 21
- Issue
- 4
- Pages
- 993-1000
- ISSN
- 1462-8902 (ISSN-L)
- 1463-1326
- OpenAlex
- W2905470527
- Cited by
- 16
- References
- 33
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 4 · 2023: 1 · 2021: 3 · 2020: 1
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Diabetes Obesity and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
- Site cant be reached (submittedVersion, other-oa)
- PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion)
- Funders
- TrygFonden
- Danmarks Grundforskningsfond (DNRF55)
- Strategiske Forskningsråd (09‐067009, 09‐075724)
- Bundesministerium für Bildung und Forschung (01GI0925)
- Bundesministerium für Bildung, Wissenschaft, Forschung und Technologie
- Augustinus Fonden
- Novo Nordisk Fonden
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- hepatic glucose production, endogenous glucose production, glucose infusion
- MeSH terms
- Administration, Intranasal, Adult, Blood Glucose, Gluconeogenesis, Glucose, Hepatic Veins, Humans, Hypoglycemic Agents, Insulin, Liver, Male, Random Allocation, Radial Artery, Cross-Over Studies, Young Adult, Healthy Volunteers
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