Prevention of type 2 diabetes in prediabetic patients by using functional olive oil enriched in oleanolic acid: The PREDIABOLE study, a randomized controlled trial
Open accessAbstract
Aim: To assess whether the regular intake of an oleanolic acid (OA)‐enriched olive oil is effective in the prevention of diabetes. Methods: In the PREDIABOLE study, prediabetic individuals (impaired fasting glucose and impaired glucose tolerance) of both sexes (176 patients, aged 30‐80 years) were randomized to receive 55 mL/day of OA‐enriched olive oil (equivalent dose 30 mg OA/day) [intervention group (IG)] or the same oil not enriched [control group (CG)]. The main outcome was the incidence of new‐onset type 2 diabetes in both groups. Results: Forty‐eight new diabetes cases occurred, 31 in the CG and 17 in the IG. The multivariate‐adjusted hazard ratio was 0.45 (95% CI, 0.24‐0.83) for the IG compared with the CG. Intervention‐related adverse effects were not reported. Conclusions: The intake of OA‐enriched olive oil reduces the risk of developing diabetes in prediabetic patients. The results of the PREDIABOLE study promote the use of OA in new functional foods and drugs for the prevention of diabetes in individuals at risk of developing it.
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Research on the health effects of OPO in humans is limited to assessment of some pure minor components administered as drugs or food supplements or as functional VOO enriched in some triterpenes.
“However, research on the health effects of OPO in humans is limited to the assessment of some pure minor components administered as drugs or food supplements [10–12] or as functional VOO enriched in some triterpenes [13, 14], yet to this date the effect of consuming OPO in the diet has not been studied.”
From Olive pomace oil can improve blood lipid profile: a randomized, blind, crossover, controlled clinical trial in healthy and at-risk volunteers (2022) · cites this paper as [14]
The Elaboration and characteristics of the functional olive oil section (page unavailable) describes a human trial using olive oil enriched with oleanolic acid, a triterpene. But it specifies that the oil was a blend of virgin and refined olive oils, not virgin olive oil (VOO) alone. (LLM, conf=0.87)
Experimental — accuracy not yet measuredTo this date, the effect of consuming OPO in the diet has not been studied.
“However, research on the health effects of OPO in humans is limited to the assessment of some pure minor components administered as drugs or food supplements [10–12] or as functional VOO enriched in some triterpenes [13, 14], yet to this date the effect of consuming OPO in the diet has not been studied.”
From Olive pomace oil can improve blood lipid profile: a randomized, blind, crossover, controlled clinical trial in healthy and at-risk volunteers (2022) · cites this paper as [14]
The Methods section (‘Elaboration and characteristics of the functional olive oil’; page unavailable) identifies this study’s oil as enriched with oleanolic acid, a triterpene, supporting the identification to which the citation is attached. It describes the oil as a blend of virgin and refined olive oils, however, not virgin olive oil (VOO) alone. The subsequent statement that dietary OPO has not been studied is not directly attributed to this citation. (LLM, conf=0.84)
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- Authors
- Santos‐Lozano, J. M., Rada, M., Lapetra, J., Guinda, Á., Jiménez‐Rodríguez, M. C., Cayuela, J. A., Ángel‐Lugo, A., Vilches‐Arenas, Á., Gómez‐Martín, A. M., Ortega‐Calvo, M., & Castellano, J. M.
- Affiliations
- Instituto de Salud Carlos III (ES)
- Consejo Superior de Investigaciones Científicas (ES)
- Universidad de Sevilla (ES)
- Department of Family Medicine Primary Health District Seville Seville Spain
- Corresponding author
- Castellano, José M.
- ORCID
- Venue
- Diabetes, Obesity and Metabolism
- Publisher
- Wiley
- Published
- 2019-08-28
- Volume
- 21
- Issue
- 11
- Pages
- 2526-2534
- ISSN
- 1462-8902 (ISSN-L)
- 1463-1326
- OpenAlex
- W2965460055
- Cited by
- 51
- References
- 33
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 6 · 2023: 14 · 2022: 10 · 2021: 5 · 2020: 4 · 2019: 2
- FWCI
- 4.26
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Diabetes Obesity and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- RISalud Institutional Health Repository of Andalucía (submittedVersion, other-oa)
- Funders
- Junta de Andalucía (PI‐0037/2008)
- European Regional Development Fund
- Instituto de Salud Carlos III (PI10/00913, PI10/01415)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- type 2 diabetes prevention, prediabetes, oleanolic acid, olive oil, functional foods, impaired fasting glucose, impaired glucose tolerance
- MeSH terms
- Olive Oil, Aged, Aged, 80 and over, Diabetes Mellitus, Type 2, Double-Blind Method, Female, Humans, Hypoglycemic Agents, Male, Middle Aged, Oleanolic Acid, Prediabetic State
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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