Involvement of dopamine signaling in the circadian modulation of interval timing
Open accessAbstract
Duration discrimination within the seconds-to-minutes range, known as interval timing, involves the interaction of cortico-striatal circuits via dopaminergic-glutamatergic pathways. Besides interval timing, most (if not all) organisms exhibit circadian rhythms in physiological, metabolic and behavioral functions with periods close to 24 h. We have previously reported that both circadian disruption and desynchronization impaired interval timing in mice. In this work we studied the involvement of dopamine (DA) signaling in the interaction between circadian and interval timing. We report that daily injections of levodopa improved timing performance in the peak-interval procedure in C57BL/6 mice with circadian disruptions, suggesting that a daily increase of DA is necessary for an accurate performance in the timing task. Moreover, striatal DA levels measured by reverse-phase high-pressure liquid chromatography indicated a daily rhythm under light/dark conditions. This daily variation was affected by inducing circadian disruption under constant light (LL). We also demonstrated a daily oscillation in tyrosine hydroxylase levels, DA turnover (3,4-dihydroxyphenylacetic acid/DA levels), and both mRNA and protein levels of the circadian component Period2 (Per2) in the striatum and substantia nigra, two brain areas relevant for interval timing. None of these oscillations persisted under LL conditions. We suggest that the lack of DA rhythmicity in the striatum under LL - probably regulated by Per2 - could be responsible for impaired performance in the timing task. Our findings add further support to the notion that circadian and interval timing share some common processes, interacting at the level of the dopaminergic system.
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Functional arrhythmocity induced by bright constant light or SCN lesions disrupted dopamine and TH rhythms and reward-related behaviors such as interval timing.
“Moreover, functional arrhythmocity induced by bright constant light (Bussi et al., 2014) or SCN lesions (Sleipness et al., 2007) disrupted dopamine and TH rhythms and reward-related behaviors such as interval timing.”
From Circadian dysregulation in Parkinson's disease (2017) · cites this paper as Bussi et al., 2014
Clock genes exhibit periodic variations in striatal structures and could be related to rhythms in the expression of dopamine-related genes.
“Clock genes also exhibit periodic variations in striatal structures (Bussi et al., 2014, Li et al., 2009, Natsubori et al., 2014), and could be related to rhythms in the expression of dopamine-related genes (Shumay et al., 2012).”
From Circadian dysregulation in Parkinson's disease (2017) · cites this paper as Bussi et al., 2014
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Circadian dysregulation in Parkinson's disease
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Self-citation
- Authors
- Bussi, I. L., Levín, G., Golombek, D. A., & Agostino, P. V.
- Affiliations
- National University of Quilmes (AR)
- Hospital de Niños Ricardo Gutiérrez CEDIE‐CONICET Gallo 1360 C1425EFD Buenos Aires Argentina
- Corresponding author
- Agostino, Patricia V.
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2014-04
- Volume
- 40
- Issue
- 1
- Pages
- 2299-2310
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W2066317640
- Cited by
- 62
- References
- 70
- Citations by year
- 2025: 3 · 2024: 4 · 2023: 1 · 2022: 5 · 2021: 4 · 2020: 20 · 2019: 1 · 2018: 4 · 2017: 9 · 2016: 4 · 2015: 5 · 2014: 2
- FWCI
- 3.25
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- CONICET Digital (CONICET) (submittedVersion, cc-by-nc-sa)
- Funders
- National Science Agency
- National Research Council
- National University of Quilmes
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
- Keywords
- dopamine signaling, interval timing, circadian rhythm, circadian rhythm disruption, constant light, striatum, substantia nigra, Per2, tyrosine hydroxylase, dopamine turnover, levodopa, duration discrimination, peak-interval procedure, corticostriatal circuits
- MeSH terms
- Animals, Circadian Rhythm, Corpus Striatum, Discrimination, Psychological, Dopamine, Levodopa, Male, Mice, Inbred C57BL, Motor Activity, Photic Stimulation, Random Allocation, RNA, Messenger, Substantia Nigra, Time Perception, Tyrosine 3-Monooxygenase, 3,4-Dihydroxyphenylacetic Acid, Dopamine Agents, Signal Transduction, Period Circadian Proteins
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