SOX 7 interferes with β‐catenin activity to promote neuronal apoptosis
Abstract
SOX 7 mediates various developmental processes. However, its role in neuronal apoptosis remains unclear. In the present study, we investigated the expression pattern and role of SOX 7 in potassium deprivation‐induced rat cerebellar granule neuron apoptosis. Our results showed that both mRNA and protein levels of SOX 7 were upregulated when potassium was deprived. SOX 7 overexpression promoted neuronal apoptosis, whereas knockdown of SOX 7 protected neurons against apoptosis. Moreover, we found that β‐catenin activity was suppressed during apoptosis and that β‐catenin inhibition was crucial for potassium deprivation‐induced neuronal apoptosis. This suppression was mediated by an interaction between SOX 7 and β‐catenin but not by protein degradation. Lastly, we showed that β‐catenin inhibition mediated the pro‐apoptotic effect of SOX 7. Together, our findings demonstrated that SOX 7 interfered with β‐catenin activity to promote neuronal apoptosis, which acted as a novel signaling mechanism in neuronal cell death.
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LHX9 is critical for early cortical specification and SOX7 for neuronal apoptosis.
“These include LHX9 and SOX7, TFs critical for early cortical specification and neuronal apoptosis, respectively (48, 49).”
From Comprehensive functional genomic resource and integrative model for the human brain (2018) · cites this paper as [49]
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- Authors
- Wang, C., Qin, L., Min, Z., Zhao, Y., Zhu, L., Zhu, J., & Yu, S.
- Affiliations
- Xiamen University (CN)
- Sun Yat-sen University (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Corresponding author
- Wang, Chong
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2015-04-30
- Volume
- 41
- Issue
- 11
- Pages
- 1430-1437
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W2027078932
- Cited by
- 18
- References
- 41
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 3 · 2022: 1 · 2021: 2 · 2019: 4 · 2018: 3 · 2017: 1 · 2016: 1
- FWCI
- 0.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- the China Postdoctoral Science Foundation funded project (2012M511621)
- the Fujian Province education and scientific research project for young teachers (JA14003)
- the Guangdong Province Medical Research Foundation (B2012080)
- the National Natural Science Foundation of China (31200737)
- the Natural Science Foundation of Fujian Province (2014J01376)
- the Specialized Research Fund for the Doctoral Program of Higher Education (20130121120050)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- SOX7, β-catenin, neuronal apoptosis, potassium deprivation, cerebellar granule cells, transcription factor interaction, neuronal cell death, gene knockdown
- MeSH terms
- Animals, Cells, Cultured, Cerebellum, Neurons, Potassium Deficiency, RNA, Messenger, Rats, Sprague-Dawley, Apoptosis, beta Catenin, Rats, SOXF Transcription Factors
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