Topical apigenin improves epidermal permeability barrier homoeostasis in normal murine skin by divergent mechanisms

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Apigenin induces dermal collagen synthesis via smad2/3 signaling pathway

Zhang, Y., Wang, J., Cheng, X., Yi, B., Zhang, X., & Li, Q. (2015) · European Journal of Histochemistry · doi:10.4081/ejh.2015.2467 · Cited by 48 · see citing works

Novel Anti-Inflammatory Approaches for Cystic Fibrosis Lung Disease: Identification of Molecular Targets and Design of Innovative Therapies

Mitri, C., Xu, Z., Bardin, P., Corvol, H., Touqui, L., & Tabary, O. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01096 · Cited by 48 · see citing works

Antioxidative Phytochemicals Accelerate Epidermal Terminal Differentiation via the AHR-OVOL1 Pathway: Implications for Atopic Dermatitis

Furue, M., Hashimoto‐Hachiya, A., & Tsuji, G. (2018) · Acta Dermato Venereologica · doi:10.2340/00015555-3003 · Cited by 43 · see citing works

Topical hesperidin prevents glucocorticoid‐induced abnormalities in epidermal barrier function in murine skin

Man, G., Mauro, T. M., Kim, P. L., Hupe, M., Zhai, Y., Sun, R. K. P., Crumrine, D., Cheung, C., Nuno‐Gonzalez, A., Elias, P. M., et al. (2014) · Experimental Dermatology · doi:10.1111/exd.12480 · Cited by 34 · see citing works

Recent Advances in the Pharmacological Actions of Apigenin, Its Complexes, and Its Derivatives

Li, Z., Zhou, J., Ji, L., Liang, Y., & Xie, S. (2022) · Food Reviews International · doi:10.1080/87559129.2022.2122989 · Cited by 31 · see citing works

Assessment of non-invasive techniques and herbal-based products on dermatological physiology and intercellular lipid properties

Ariffin, N. H. M., & Hasham, R. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e03955 · Cited by 28 · see citing works

Carotenoids co-localize with hydroxyapatite, cholesterol, and other lipids in calcified stenotic aortic valves. Ex vivo Raman maps compared to histological patterns

Bonetti, A., Bonifacio, A., Mora, A. D., Livi, U., Marchini, M., & Ortolani, F. (2015) · European Journal of Histochemistry · doi:10.4081/ejh.2015.2505 · Cited by 25 · see citing works

Croton urucurana Baillon stem bark ointment accelerates the closure of cutaneous wounds in knockout IL-10 mice

Casao, T. D. R. L., Pinheiro, C. G., Sarandy, M. M., Zanatta, A. C., Vilegas, W., Novaes, R. D., Gonçalves, R. V., & Leite, J. P. V. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.113042 · Cited by 21 · see citing works

Skin Barrier Function and Atopic Dermatitis

Rerknimitr, P., Otsuka, A., Nakashima, C., & Kabashima, K. (2018) · Current Dermatology Reports · doi:10.1007/s13671-018-0232-y · Cited by 21 · see citing works

Antioxidant Houttuynia cordata extract upregulates filaggrin expression in an aryl hydrocarbon-dependent manner.

Doi, K., Mitoma, C., Nakahara, T., Uchi, H., Hashimoto‐Hachiya, A., Takahara, M., Tsuji, G., Nakahara, M., & Furue, M. (2014) · PubMed · doi:10.15017/1495227 · Cited by 19 · see citing works

Targeted Delivery Strategies for Hydrophilic Phytochemicals

Sharafan, M., Dziki, A., Malinowska, M. A., Sikora, E. S., & Szopa, A. (2025) · Applied Sciences · doi:10.3390/app15137101 · Cited by 18 · see citing works

The regulation of protein kinase casein kinase II by apigenin is involved in the inhibition of ultraviolet B‐induced macrophage migration inhibitory factor‐mediated hyperpigmentation

Yoshihisa, Y., Andoh, T., Rehman, M. U., & Shimizu, T. (2019) · Phytotherapy Research · doi:10.1002/ptr.6597 · Cited by 16 · see citing works

Potentials of plant derived products for the treatment of skin disorders

Maurya, S. K., Divakar, S., & Patil, U. K. (2023) · German Journal of Pharmaceuticals and Biomaterials · doi:10.5530/gjpb.2023.3.8 · Cited by 13 · see citing works

Improvement of Skin Barrier Dysfunction by Phenolic‐containing Extracts of Lycium barbarum via Nrf2/HO‐1 Regulation

Liu, G., Li, Y., Wang, J., Dong, C., Deng, M., Tai, M., Deng, L., Che, B., Li, L., Du, Z., et al. (2021) · Photochemistry and Photobiology · doi:10.1111/php.13498 · Cited by 12 · see citing works

Determination of Apigenin in Cosmetics Containing Chamomile by High-Performance Liquid Chromatography with Ultraviolet Detection (HPLC-UV)

Serim, E., Ceylan, B., & Tekkeli, Ş. E. K. (2022) · Analytical Letters · doi:10.1080/00032719.2022.2155180 · Cited by 12 · see citing works

Pathomechanism of ‘skin-originated’ allergic diseases

Egawa, G. (2018) · Immunological Medicine · doi:10.1080/25785826.2018.1540257 · Cited by 11 · see citing works

Therapeutic benefits of enhancing permeability barrier for atopic eczema

Man, G., Elias, P. M., & Man, M. (2015) · Dermatologica Sinica · doi:10.1016/j.dsi.2015.03.006 · Cited by 11 · see citing works

Unique molecule filaggrin in epidermal structure and its role in the xerosis development and atopic dermatitis pathogenesis

Тамразова, О. Б., & Glukhova, E. A. (2021) · Russian Journal of Clinical Dermatology and Venereology · doi:10.17116/klinderma202120061102 · Cited by 10 · see citing works

Therapeutic effects and mechanisms of Ku-Gan formula on atopic dermatitis: A pilot clinical study and modular pharmacology analysis with animal validation

Ma, X., Kuai, L., Song, J., Luo, Y., Ru, Y., Wang, M., Gao, C., Jiang, W., Liu, Y., Bai, Y., et al. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116194 · Cited by 10 · see citing works

Regulation of Host Defense Peptide Synthesis by Polyphenols

Tobin, I., & Zhang, G. (2023) · Antibiotics · doi:10.3390/antibiotics12040660 · Cited by 10 · see citing works

Ameliorated membranous nephropathy activities of two ethanol extracts from corn silk and identification of flavonoid active compounds by LC-MS 2

Wang, X., Yuan, L., Dong, Y., Bao, Z., Ma, T., & Lin, S. (2021) · Food & Function · doi:10.1039/d1fo01947c · Cited by 10 · see citing works

Phytochemical profiling by UPLC-ESI-QTOF-MS of Commelina africana, widely used in traditional medicine in DR Congo

Kembelo, P. K., Tuenter, E., Vanhove, W., Katula, H. B., Damme, P. V., & Pieters, L. A. C. (2023) · South African Journal of Botany · doi:10.1016/j.sajb.2023.04.010 · Cited by 9 · see citing works

Benefits of topical natural ingredients in epidermal permeability barrier

Lei, D., Liu, D., Zhang, J., Zhang, L., & Man, M. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2023.1275506 · Cited by 11 · see citing works

Herbal medicines that benefit epidermal permeability barrier function

Hu, L., Man, H., Elias, P. M., & Man, M. (2015) · Dermatologica Sinica · doi:10.1016/j.dsi.2015.04.009 · Cited by 9 · see citing works

Improved Skin Barrier Function Along with Hydration Benefits of Viola yedoensis Extract, Aesculin, and Schaftoside and LC-HRMS/MS Dereplication of Its Bio-Active Components

Sreelatha, T., Sousa, S. D., Dubuis, A., Boudah, S., Mehta, R., Singh, A., Eilstein, J., Tabet, J., John, S., Roy, D., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312770 · Cited by 8 · see citing works

Traditional Herbal Medicines, Newer Herbs and Other Novel Approaches Integrated in Herbal Medicine for Atopic Dermatitis-A Narrative Review

Kumar, P., Sharma, D. K., & Ashawat, M. S. (2019) · Current Drug Therapy · doi:10.2174/1574885514666191018165209 · Cited by 7 · see citing works

Flavonoids in atopic dermatitis: mechanisms, delivery innovations, and translational strategies

Li, D., Han, Y., Zhou, J., Chen, J., Tey, H. L., & Tan, T. T. Y. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1631977 · Cited by 7 · see citing works

Filaggrin compound heterozygous patients carry mutations in trans position

Carlsen, B. C., Meldgaard, M., Johansen, J. D., Thyssen, J. P., Menné, T., Szecsi, P. B., & Stender, S. (2013) · Experimental Dermatology · doi:10.1111/exd.12199 · Cited by 6 · see citing works

An optimized inexpensive emollient mixture improves barrier repair in murine skin

Man, G., Cheung, C., Crumrine, D. A., Hupe, M., Hill, Z. E., Man, M., & Elias, P. M. (2015) · Dermatologica Sinica · doi:10.1016/j.dsi.2015.03.010 · Cited by 6 · see citing works

Integrating network pharmacology, experimental validation and molecular dynamics simulation to investigate the underlying mechanism of apigenin against diabetic wound

Pu, P., Zheng, F., Wang, H. H., Wen, H., Zhang, L. N., & Ma, J. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.152113 · Cited by 4 · see citing works

Selected Medicinal Herbs and Functional Peptides for Protection against Photoaging of the Skin

Liang, Y., Meiyin, W., & Chen, Y. (2019) · Journal of Cosmetics Dermatological Sciences and Applications · doi:10.4236/jcdsa.2019.91001 · Cited by 4 · see citing works

Mutations in 3β‐hydroxysteroid‐δ8, δ7‐isomerase paradoxically benefit epidermal permeability barrier homeostasis in mice

Dang, E., Man, G., Lee, D. Y., Crumrine, D., Mauro, T. M., Elias, P. M., & Man, M. (2020) · Experimental Dermatology · doi:10.1111/exd.14236 · Cited by 2 · see citing works

Translational potential of natural bioactive-based formulations in atopic dermatitis: Current insights

Kaushal, P., & Awasthi, R. (2025) · Medicine in Novel Technology and Devices · doi:10.1016/j.medntd.2025.100404 · Cited by 2 · see citing works

Natural Product Modulation of Oxidative Stress in the Treatment of Extrinsic Skin Aging: Mechanisms of Action and Future Perspectives

Zhang, X., Wang, J., Kang, J., Li, J., Li, J., Guo, C., Hao, Z., & Liu, D. (2026) · Chemical Research in Chinese Universities · doi:10.1007/s40242-026-6027-y · Cited by 1 · see citing works

Chrysanthemum in skin lightening and anti-photoaging: Phytochemical basis, mechanistic convergence, and translational evidence

Huang, J., Yu, H., Huang, Y., He, T., Ruan, J., Wang, H. B., Chen, R., Li, S., Sun, D., & Yu, H. (2026) · Industrial Crops and Products · doi:10.1016/j.indcrop.2026.123751 · Cited by 1 · see citing works

Therapeutics and Other Interventions

Carlsen, B. C. (2014) · Springer eBooks · doi:10.1007/978-3-642-54379-1_36 · Cited by 1 · see citing works

Development of CXCR4 Inhibitors for Topical Treatment of Psoriasis

Boonsith, S. (2017) · DigitalCommons@UNMC · Cited by 1 · see citing works

Screening and characterization of active herbal extracts and components stimulating human beta defensing (hBD-3) expression from HaCaT cells

Songmi, L. E. E., Yu-Min, C. H. O. I., & Yim, S. (2022) · Food Science and Technology · doi:10.1590/fst.112121 · Cited by 1 · see citing works

Barrier Products for Topical Delivery—Insight into Efficacy Testing and Barrier-Boosting Compounds

Bagińska, Z. H., & Szymańska, E. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17111361 · Cited by 1 · see citing works

Cells in the Skin

Wang, X.-Q., Gao, X.-H., Zhang, X.-L., Zhou, L., Mi, Q.-S., Hong, Y.-X., Song, B., McGovern, N., Lim, S., Tang, M. B. Y., et al. (2017) · Springer eBooks · doi:10.1007/978-94-024-0902-4_6 · Cited by 2 · see citing works

Novel Anti-inflammatory Approaches for Cystic Fibrosis Lung Disease: Identification of Molecular Targets and Design of Innovative Therapies

(2022) · Frontiers research topics · doi:10.3389/978-2-88971-941-9

Ethnobotanical study and characterization of medicinal plants used by the population of the Kisantu and Mbanza-Ngungu territories, Kongo Central Province (DR Congo)

Kembelo, P. K. (2024) · doi:10.63028/10067/2056400151162165141

Advancing psoriasis management through the application of secondary metabolites: A detailed review of phytoconstituents and their multifaceted mechanisms

Shaikh, F. N., Sheikh, S. S., Tatode, A., Hussain, U., Premchandani, T., Khan, R., Sharma, P., & Qutub, M. (2025) · Pharmacological Research - Natural Products · doi:10.1016/j.prenap.2025.100451

Plant-Derived Carbonic Anhydrase IV and IX Inhibitors: Predictive Pharmacodynamics and Therapeutic Potential

Mareş, C., PĂUN, A. M., Mernea, M., Matanie, A.-C., Cristea, B. M., Marinaș, I. C., & Avram, S. (2026) · Processes · doi:10.3390/pr14183016

Beyond Conventional: A Review of Phytochemical‐Hydrogel Systems Enhanced by AI and 3D Printing for Chronic Wound Management

Zhou, Y., Liu, X., Wang, C., Zhao, X., PengRun, Z., Gu, J., Sun, Q., Xing, M. M. Q., & Yang, Y. (2026) · Advanced Science · doi:10.1002/advs.77770

Alnustone ameliorates atopic dermatitis by rebalancing TAp63/ΔNp63 to upregulate filaggrin and restore skin barrier function

Wang, C., Tang, K., & Guo, Y. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.118535

A topical Chinese herbal mixture improves epidermal permeability barrier function in normal murine skin

Man, M., Hupe, M., Mackenzie, D., Kim, H., Oda, Y., Crumrine, D., Lee, S. H., Martín‐Ezquerra, G., Trullas, C., Mauro, T. M., et al. (2011) · Experimental Dermatology · doi:10.1111/j.1600-0625.2010.01205.x · Cited by 16 · see citing works

Topical hesperidin improves epidermal permeability barrier function and epidermal differentiation in normal murine skin

Hou, M., Man, M., Man, W., Zhu, W., Hupe, M., Park, K., Crumrine, D., Elias, P. M., & Man, M. (2012) · Experimental Dermatology · doi:10.1111/j.1600-0625.2012.01455.x · Cited by 62 · see citing works

Herbal medicines that benefit epidermal permeability barrier function

Hu, L., Man, H., Elias, P. M., & Man, M. (2015) · Dermatologica Sinica · doi:10.1016/j.dsi.2015.04.009 · Cited by 9 · see citing works

Topical Apigenin Alleviates Cutaneous Inflammation in Murine Models

Man, M., Hupe, M., Sun, R. K. P., Man, G., Mauro, T. M., & Elias, P. M. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/912028 · Cited by 52 · see citing works

Benefits of topical natural ingredients in epidermal permeability barrier

Lei, D., Liu, D., Zhang, J., Zhang, L., & Man, M. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2023.1275506 · Cited by 11 · see citing works