Multifactorial skin barrier deficiency and atopic dermatitis: Essential topics to prevent the atopic march

Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis

Palmer, C. N. A., Irvine, A. D., Terron-Kwiatkowski, A., Zhao, Y., Liao, H., Lee, S. P., Goudie, D. R., Sandilands, A., Campbell, L. E., Smith, F. J. D., et al. (2006) · Nature Genetics · doi:10.1038/ng1767 · Cited by 2,978 · see citing works

Claudin-based tight junctions are crucial for the mammalian epidermal barrier

Furuse, M., Hata, M., Furuse, K., Yoshida, Y., Haratake, A., Sugitani, Y., Noda, T., Kubo, A., & Tsukita, S. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200110122 · Cited by 1,512 · see citing works

Atopic dermatitis and the atopic march

Spergel, J. M., & Paller, A. S. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2003.09.033 · Cited by 1,229 · see citing works

Cytokine modulation of atopic dermatitis filaggrin skin expression

Howell, M. D., Kim, B. E., Gao, P., Grant, A. V., Boguniewicz, M., DeBenedetto, A., Schneider, L., Beck, L. A., Barnes, K. C., & Leung, D. Y. M. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.04.031 · Cited by 1,084 · see citing works

Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris

Smith, F. J. D., Irvine, A. D., Terron-Kwiatkowski, A., Sandilands, A., Campbell, L., Zhao, Y., Liao, H., Evans, A. T., Goudie, D. R., Lewis‐Jones, S., et al. (2006) · Nature Genetics · doi:10.1038/ng1743 · Cited by 1,026 · see citing works

Randomized Trial of Introduction of Allergenic Foods in Breast-Fed Infants

Perkin, M. R., Logan, K., Tseng, A., Raji, B., Ayis, S. A., Peacock, J. L., Brough, H. A., Marrs, T., Radulović, S., Craven, J., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1514210 · Cited by 889 · see citing works

Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome

Chavanas, S., Bodemer, C., Rochat, A., Hamel‐Teillac, D., Ali, M., Irvine, A. D., Bonafé, J., WILKINSON, J. D., Taı̈eb, A., Barrandon, Y., et al. (2000) · Nature Genetics · doi:10.1038/75977 · Cited by 851 · see citing works

Epidermal Barrier Dysfunction in Atopic Dermatitis

Cork, M. J., Danby, S. G., Vasilopoulos, Y., Hadgraft, J., Lane, M. E., Moustafa, M., Guy, R. H., MacGowan, A., Ahnini, R. T., & Ward, S. J. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.133 · Cited by 782 · see citing works

Tight junction defects in patients with atopic dermatitis

Benedetto, A. D., Rafaels, N. M., McGirt, L. Y., Ivanov, A. I., Georas, S. N., Cheadle, C., Berger, A. E., Zhang, K., Vidyasagar, S., Yoshida, T., et al. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.10.018 · Cited by 750 · see citing works

Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention

Simpson, E. L., Chalmers, J. R., Hanifin, J. M., Thomas, K. S., Cork, M. J., McLean, W. H. I., Brown, S. J., Chen, Z., Chen, Y., & Williams, H. C. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.08.005 · Cited by 722 · see citing works

Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema

Sandilands, A., Terron-Kwiatkowski, A., Hull, P. R., O’Regan, G. M., Clayton, T. H., Watson, R. M., Carrick, T., Evans, A. T., Liao, H., Zhao, Y., et al. (2007) · Nature Genetics · doi:10.1038/ng2020 · Cited by 662 · see citing works

Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

Paternoster, L., Kemp, J. P., Zheng, J., Smith, G. D., Relton, C. L., Evans, D. M., McArdle, W. L., Henderson, A. J., Standl, M., Tiesler, C. M. T., et al. (2015) · Nature Genetics · doi:10.1038/ng.3424 · Cited by 614 · see citing works

Application of moisturizer to neonates prevents development of atopic dermatitis

Horimukai, K., Morita, K., Narita, M., Kondo, M., Kitazawa, H., Nozaki, M., Shigematsu, Y., Yoshida, K., Niizeki, H., Motomura, K.-I., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.07.060 · Cited by 607 · see citing works

Efficacy and safety of dupilumab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments: a randomised, placebo-controlled, dose-ranging phase 2b trial

Thaçi, D., Simpson, E. L., Beck, L. A., Bieber, T. R. M., Blauvelt, A., Papp, K. A., Soong, W., Worm, M., Szepietowski, J. C., Sofen, H. L., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(15)00388-8 · Cited by 573 · see citing works

From atopic dermatitis to asthma: the atopic march

Spergel, J. M. (2010) · Annals of Allergy, Asthma & Immunology · doi:10.1016/j.anai.2009.10.002 · Cited by 525 · see citing works

A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming

Fallon, P. G., Sasaki, T., Sandilands, A., Campbell, L., Saunders, S. P., Mangan, N. E., Callanan, J. J., Kawasaki, H., Shiohama, A., Kubo, A., et al. (2009) · Nature Genetics · doi:10.1038/ng.358 · Cited by 474 · see citing works

Filaggrin in atopic dermatitis

O’Regan, G. M., Sandilands, A., McLean, W. H. I., & Irvine, A. D. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.07.013 · Cited by 442 · see citing works

Effect of Avoidance on Peanut Allergy after Early Peanut Consumption

Toit, G. D., Sayre, P. H., Roberts, G. C., Sever, M. L., Lawson, K., Bahnson, H. T., Brough, H. A., Santos, A. F., Harris, K. M., Radulović, S., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1514209 · Cited by 411 · see citing works

Gene polymorphism in Netherton and common atopic disease

Walley, A. J., Chavanas, S., Moffatt, M. F., Esnouf, R. M., Ubhi, B., Lawrence, R., Wong, K., Abecasis, G. R., Jones, E. Y., Harper, J. I., et al. (2001) · Nature Genetics · doi:10.1038/ng728 · Cited by 399 · see citing works

Epidermal barrier dysfunction and cutaneous sensitization in atopic diseases

Kubo, A., Nagao, K., & Amagai, M. (2012) · Journal of Clinical Investigation · doi:10.1172/jci57416 · Cited by 378 · see citing works

Dissecting the formation, structure and barrier function of the stratum corneum

Matsui, T., & Amagai, M. (2015) · International Immunology · doi:10.1093/intimm/dxv013 · Cited by 368 · see citing works

New concept of the pathogenesis of atopic dermatitis: Interplay among the barrier, allergy, and pruritus as a trinity

Kabashima, K. (2013) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2013.02.001 · Cited by 360 · see citing works

Mutations in ABCA12 Underlie the Severe Congenital Skin Disease Harlequin Ichthyosis

Kelsell, D. P., Norgett, E. E., Unsworth, H., Teh, M., Cullup, T., Mein, C. A., Dopping-Hepenstal, J. P., Dale, A. B., Tadini, G., Fleckman, P. H., et al. (2005) · The American Journal of Human Genetics · doi:10.1086/429844 · Cited by 351 · see citing works

“Outside-to-Inside” (and Now Back to “Outside”) Pathogenic Mechanisms in Atopic Dermatitis

Elias, P. M., & Steinhoff, M. S. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.88 · Cited by 344 · see citing works

Desmoglein 1 deficiency results in severe dermatitis, multiple allergies and metabolic wasting

Samuelov, L., Sarig, O., Harmon, R. M., Rapaport, D., Ishida‐Yamamoto, A., Isakov, O., Koetsier, J. L., Gat, A., Goldberg, I., Bergman, R., et al. (2013) · Nature Genetics · doi:10.1038/ng.2739 · Cited by 336 · see citing works

LEKTI Fragments Specifically Inhibit KLK5, KLK7, and KLK14 and Control Desquamation through a pH-dependent Interaction

Deraison, C., Bonnart, C., Lopez, F., Besson‐Fournier, C., Robinson, R. A., Jayakumar, A., Wågberg, F., Brattsand, M., Hachem, J. P., Leonardsson, G., et al. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-02-0124 · Cited by 329 · see citing works

A Proteolytic Cascade of Kallikreins in the Stratum Corneum

Brattsand, M., Stefansson, K., Lundh, C., Haasum, Y., & Egelrud, T. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.23547.x · Cited by 327 · see citing works

Characterization of overall ceramide species in human stratum corneum

Masukawa, Y., Narita, H., Shimizu, E., Kondo, N., Sugai, Y., Oba, T., Homma, R., Ishikawa, J., Takagi, Y., Kitahara, T., et al. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800014-jlr200 · Cited by 322 · see citing works

Sustained Serine Proteases Activity by Prolonged Increase in pH Leads to Degradation of Lipid Processing Enzymes and Profound Alterations of Barrier Function and Stratum Corneum Integrity

Hachem, J. P., Man, M.-Q., Crumrine, D. A., Uchida, Y., Brown, B. E., Rogiers, V., Roseeuw, D. I., Feingold, K. R., & Elias, P. M. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23838.x · Cited by 314 · see citing works

Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease

Kottyan, L. C., Davis, B. P., Sherrill, J. D., Liu, K., Rochman, M., Kaufman, K. M., Weirauch, M. T., Vaughn, S. E., Lázaro, S., Rupert, A., et al. (2014) · Nature Genetics · doi:10.1038/ng.3033 · Cited by 305 · see citing works

Exposure to food allergens through inflamed skin promotes intestinal food allergy through the thymic stromal lymphopoietin–basophil axis

Noti, M., Kim, B., Siracusa, M. C., Rak, G. D., Kubo, M., Moghaddam, A. E., Sattentau, Q. J., Comeau, M. R., Spergel, J. M., & Artis, D. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.01.021 · Cited by 302 · see citing works

Altered stratum corneum barrier and enhanced percutaneous immune responses in filaggrin-null mice

Kawasaki, H., Nagao, K., Kubo, A., Hata, T., Shimizu, A., Mizuno, H., Yamada, T., & Amagai, M. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.01.068 · Cited by 301 · see citing works

Defective stratum corneum and early neonatal death in mice lacking the gene for transglutaminase 1 (keratinocyte transglutaminase)

Matsuki, M., Yamashita, F., Ishida‐Yamamoto, A., Yamada, K., Kinoshita, C., Fushiki, S., Ueda, E., Morishima, Y., Tabata, K., Yasuno, H., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.3.1044 · Cited by 292 · see citing works

IL-31 regulates differentiation and filaggrin expression in human organotypic skin models

Cornelissen, C., Marquardt, Y., Czaja, K., Wenzel, J., Frank, J., Lüscher‐Firzlaff, J., Lüscher, B., & Baron, J. M. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.10.042 · Cited by 292 · see citing works

Gentamicin‐induced readthrough of stop codons in duchenne muscular dystrophy

Malik, V., Rodino‐Klapac, L. R., Viollet, L., Wall, C., King, W. M., Al‐Dahhak, R., Lewis, S., Shilling, C. J., Kota, J., Serrano, C., et al. (2010) · Annals of Neurology · doi:10.1002/ana.22024 · Cited by 280 · see citing works

Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency

Kežić, S., O’Regan, G. M., Lutter, R., Jakaša, I., Koster, E. S., Saunders, S. P., Caspers, P. J., Kemperman, P. M. J. H., Puppels, G. J., Sandilands, A., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.12.989 · Cited by 276 · see citing works

Unique mutations in the filaggrin gene in Japanese patients with ichthyosis vulgaris and atopic dermatitis

Nomura, T., Sandilands, A., Akiyama, M., Liao, H., Evans, A. T., Sakai, K., Ota, M., Sugiura, H., Yamamoto, K., Satō, H., et al. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.12.646 · Cited by 272 · see citing works

The epidermal barrier function is dependent on the serine protease CAP1/Prss8

Leyvraz, C., Charles, R., Rubera, I., Guitard, M., Rotman, S., Breiden, B., Sandhoff, K., & Hümmler, E. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200501038 · Cited by 272 · see citing works

Lessons from Loricrin-Deficient Mice

Koch, P. J., de Viragh, P. A., Scharer, E., Bundman, D. S., Longley, M. A., Bickenbach, J. R., Kawachi, Y., Suga, Y., Zhou, Z., Huber, M., et al. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.2.389 · Cited by 267 · see citing works

The Janus kinase inhibitor JTE-052 improves skin barrier function through suppressing signal transducer and activator of transcription 3 signaling

Amano, W., Nakajima, S., Kunugi, H., Numata, Y., Kitoh, A., Egawa, G., Dainichi, T., Honda, T., Otsuka, A., Kimoto, Y., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.03.051 · Cited by 259 · see citing works

Assembly of the epidermal cornified cell envelope

Kalinin, A., Marekov, L. N., & Steinert, P. M. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.17.3069 · Cited by 250 · see citing works

A novel function for transglutaminase 1: Attachment of long-chain ω-hydroxyceramides to involucrin by ester bond formation

Nemes, Z., Marekov, L. N., Fésüs, L., & Steinert, P. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.15.8402 · Cited by 250 · see citing works

Langerhans cells are critical in epicutaneous sensitization with protein antigen via thymic stromal lymphopoietin receptor signaling

Nakajima, S., Igyártó, B. Z., Honda, T., Egawa, G., Otsuka, A., Hara‐Chikuma, M., Watanabe, N., Ziegler, S. F., Tomura, M., Inaba, K., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.01.063 · Cited by 244 · see citing works

Loss of Corneodesmosin Leads to Severe Skin Barrier Defect, Pruritus, and Atopy: Unraveling the Peeling Skin Disease

Oji, V., Eckl, K., Aufenvenne, K., Nätebus, M., Tarinski, T., Ackermann, K., Seller, N., Metze, D., Nürnberg, G., Fölster‐Holst, R., et al. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.07.005 · Cited by 242 · see citing works

Transglutaminase Function in Epidermis

Eckert, R. L., Sturniolo, M. T., Broome, A., Ruse, M., & Rorke, E. A. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23627.x · Cited by 242 · see citing works

Effect of filaggrin breakdown products on growth of and protein expression by Staphylococcus aureus

Miajlović, H., Fallon, P. G., Irvine, A. D., & Foster, T. J. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.09.015 · Cited by 242 · see citing works

The Human Skin Barrier Is Organized as Stacked Bilayers of Fully Extended Ceramides with Cholesterol Molecules Associated with the Ceramide Sphingoid Moiety

Iwai, I., Han, H., den Hollander, L., Svensson, S., Öfverstedt, L., Anwar, J., Brewer, J. R., Bloksgaard, M., Laloeuf, A., Nosek, D., et al. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.43 · Cited by 239 · see citing works

Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin

Pellerin, L., Henry, J., Hsu, C.-Y., Balica, S., Jean-Decoster, C., Méchin, M.-C., Hansmann, B., Rodriguez, E., Weindinger, S., Schmitt, A.-M., et al. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.12.1566 · Cited by 239 · see citing works

The cutaneous innate immune response in patients with atopic dermatitis

Kuo, I., Yoshida, T., Benedetto, A. D., & Beck, L. A. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.12.1563 · Cited by 232 · see citing works

Caspase-14 Is Required for Filaggrin Degradation to Natural Moisturizing Factors in the Skin

Hoste, E., Kemperman, P. M. J. H., Devos, M., Denecker, G., Kežić, S., Yau, N. L. H., Gilbert, B., Lippens, S., Groote, P. D., Roelandt, R., et al. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.153 · Cited by 214 · see citing works

Stratum Corneum pH in Atopic Dermatitis

Rippke, F., Schreiner, V., Doering, T., & Maïbach, H. I. (2004) · American Journal of Clinical Dermatology · doi:10.2165/00128071-200405040-00002 · Cited by 213 · see citing works

The role of hair follicles in the percutaneous absorption of caffeine

Otberg, N., Patzelt, A., Расулев, У. Х., Hagemeister, T., Linscheid, M. W., Sinkgraven, R., Sterry, W., & Lademann, J. M. (2007) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2007.03065.x · Cited by 213 · see citing works

Association of SPINK5 gene polymorphisms with atopic dermatitis in the Japanese population

Kato, A., Fukai, K., Oiso, N., Hosomi, N., Murakami, T., & Ishii, M. (2003) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2003.05243.x · Cited by 198 · see citing works

Mice lacking desmocollin 1 show epidermal fragility accompanied by barrier defects and abnormal differentiation

Chidgey, M., Brakebusch, C., Gustafsson, E., Cruchley, A. T., Hail, C., Kirk, S., Merritt, A. J., North, A. J., Tselepis, C., Hewitt, J., et al. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200105009 · Cited by 198 · see citing works

Eosinophilic esophagitis–linked calpain 14 is an IL-13–induced protease that mediates esophageal epithelial barrier impairment

Davis, B. P., Stucke, E. M., Khorki, M. E., Litosh, V. A., Rymer, J. K., Rochman, M., Travers, J., Kottyan, L. C., & Rothenberg, M. E. (2016) · JCI Insight · doi:10.1172/jci.insight.86355 · Cited by 187 · see citing works

Epidermal Overexpression of Stratum Corneum Chymotryptic Enzyme in Mice: A Model for Chronic Itchy Dermatitis

Bäckman, A., Ny, A., Edlund, M., Ekholm, E., Hammarström, B., Törnell, J., Wallbrandt, P., Egelrud, T., Hansson, L., & Wennbo, H. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01684.x · Cited by 180 · see citing works

Urea uptake enhances barrier function and antimicrobial defense in humans by regulating epidermal gene expression

Grether-Beck, S., Felsner, I., Brenden, H., Kohne, Z., Majora, M., Marini, A., Jaenicke, T., Rodriguez-Martin, M., Trullas, C., Hupe, M., et al. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.42 · Cited by 180 · see citing works

Filaggrin-2 variation is associated with more persistent atopic dermatitis in African American subjects

Margolis, D. J., Gupta, J., Apter, A. J., Ganguly, T., Hoffstad, O., Papadopoulos, M., Rebbeck, T. R., & Mitra, N. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.09.015 · Cited by 175 · see citing works

Neutral Cysteine Protease Bleomycin Hydrolase Is Essential for the Breakdown of Deiminated Filaggrin into Amino Acids

Kamata, Y., Taniguchi, A., Yamamoto, M., Nomura, J., Ishihara, K., Takahara, H., Hibino, T., & Takeda, A. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m807908200 · Cited by 170 · see citing works

Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity

Saunders, S. P., Moran, T., Floudas, A., Wurlod, F., Kaszlikowska, A., Salimi, M., Quinn, E. M., Oliphant, C. J., Núñez, G., McManus, R., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.06.045 · Cited by 160 · see citing works

Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects

Saunders, S. P., Goh, C. S. M., Brown, S., Palmer, C. N. A., Porter, R. M., Cole, C., Campbell, L., Gierliński, M., Barton, G. J., Schneider, G., et al. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.08.046 · Cited by 160 · see citing works

Recent advances in urocanic acid photochemistry, photobiology and photoimmunology

Gibbs, N. K., Tye, J., & Norval, M. (2008) · Photochemical & Photobiological Sciences · doi:10.1039/b717398a · Cited by 159 · see citing works

Mice deficient in involucrin, envoplakin, and periplakin have a defective epidermal barrier

Sevilla, L. M., Nachat, R., Groot, K. R., Klement, J. F., Uitto, J., Djian, P., Määttå, A., & Watt, F. M. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200706187 · Cited by 147 · see citing works

Peptidylarginine Deiminase Isoforms 1–3 Are Expressed in the Epidermis and Involved in the Deimination of K1 and Filaggrin

Nachat, R., Méchin, M., Takahara, H., Chavanas, S., Charvéron, M., Serre, G., & Simon, M. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.23568.x · Cited by 147 · see citing works

Tight junctions form a barrier in human epidermis

Kirschner, N., Houdek, P., Fromm, M., Moll, I., & Brandner, J. M. (2010) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2010.07.010 · Cited by 139 · see citing works

A Homozygous Missense Mutation in TGM5 Abolishes Epidermal Transglutaminase 5 Activity and Causes Acral Peeling Skin Syndrome

Cassidy, A., Steensel, M. A. M. V., Steijlen, P. M., van Geel, M., van der Velden, J. J. A. J., Morley, S. M., Terrinoni, A., Melino, G., Candi, E., & McLean, W. H. I. (2005) · The American Journal of Human Genetics · doi:10.1086/497707 · Cited by 139 · see citing works

Aloxe3 Knockout Mice Reveal a Function of Epidermal Lipoxygenase-3 as Hepoxilin Synthase and Its Pivotal Role in Barrier Formation

Krieg, P., Rosenberger, S. F., de Juanes, S., Latzko, S., Hou, J. L., Dick, A., Kloz, U., van der Hoeven, F., Haußer, I., Esposito, I., et al. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.250 · Cited by 134 · see citing works

IL-33 impacts on the skin barrier by downregulating the expression of filaggrin

Seltmann, J., Roesner, L. M., von Hesler, F.-W., Wittmann, M., & Werfel, T. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.01.048 · Cited by 134 · see citing works

The role of lipoxygenases in epidermis

Krieg, P., & Fürstenberger, G. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.08.005 · Cited by 133 · see citing works

Analysis of SPINK 5, KLK 7 and FLG Genotypes in a French Atopic Dermatitis Cohort

Hubiche, T., Ged, C., Bénard, A., Léauté-Labrèze, C., McElreavey, K., de Verneuil, H., Taı̈eb, A., & Boralévi, F. (2007) · Acta Dermato Venereologica · doi:10.2340/00015555-0329 · Cited by 132 · see citing works

SASPase regulates stratum corneum hydration through profilaggrin‐to‐filaggrin processing

Matsui, T., Miyamoto, K., Kubo, A., Kawasaki, H., Ebihara, T., Hata, K., Tanahashi, S., Ichinose, S., Imoto, I., Inazawa, J., et al. (2011) · EMBO Molecular Medicine · doi:10.1002/emmm.201100140 · Cited by 123 · see citing works

A homozygous nonsense mutation in the gene for Tmem79, a component for the lamellar granule secretory system, produces spontaneous eczema in an experimental model of atopic dermatitis

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Novel filaggrin mutation but no other loss-of-function variants found in Ethiopian patients with atopic dermatitis

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Transgenic kallikrein 5 mice reproduce major cutaneous and systemic hallmarks of Netherton syndrome

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Plakophilin-3-Deficient Mice Develop Hair Coat Abnormalities and Are Prone to Cutaneous Inflammation

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Full Sequencing of the FLG Gene in Italian Patients with Atopic Eczema: Evidence of New Mutations, but Lack of an Association

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Filaggrin loss-of-function mutations are not a predisposing factor for atopic dermatitis in an Ishigaki Island under subtropical climate

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Periplakin Gene Targeting Reveals a Constituent of the Cornified Cell Envelope Dispensable for Normal Mouse Development

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Self-Improvement of Keratinocyte Differentiation Defects During Skin Maturation in ABCA12-Deficient Harlequin Ichthyosis Model Mice

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KAPOSI'S VARICELLIFORM ERUPTION

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Development of an Ichthyosiform Phenotype in Alox12b-Deficient Mouse Skin Transplants

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Reduced Inflammatory Threshold Indicates Skin Barrier Defect in Transglutaminase 3 Knockout Mice

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A synonymous variation in protease-activated receptor-2 is associated with atopy in Korean children.

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Pathophysiology of atopic dermatitis: Clinical implications

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The immunology of atopic dermatitis and its reversibility with broad-spectrum and targeted therapies

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The immunological anatomy of the skin

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The epithelial immune microenvironment (EIME) in atopic dermatitis and psoriasis

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Gut–organ axis: a microbial outreach and networking

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Commensal microbiota regulates skin barrier function and repair via signaling through the aryl hydrocarbon receptor

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Cutaneous Barriers and Skin Immunity: Differentiating A Connected Network

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Nemolizumab in patients with moderate-to-severe atopic dermatitis: Randomized, phase II, long-term extension study

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Barrier dysfunction in the skin allergy

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The Skin Barrier and Moisturization: Function, Disruption, and Mechanisms of Repair

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Therapeutic pipeline for atopic dermatitis: End of the drought?

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Etiology of epithelial barrier dysfunction in patients with type 2 inflammatory diseases

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The etiopathogenesis of atopic dermatitis: barrier disruption, immunological derangement, and pruritus

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A phase 2, randomized dose-finding study of tapinarof (GSK2894512 cream) for the treatment of atopic dermatitis

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Interleukin‐31 and interleukin‐31 receptor: New therapeutic targets for atopic dermatitis

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A comprehensive review of natural products against atopic dermatitis: Flavonoids, alkaloids, terpenes, glycosides and other compounds

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The central role of IL-33/IL-1RL1 pathway in asthma: From pathogenesis to intervention

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Efficacy and patient-reported outcomes from a phase 2b, randomized clinical trial of tapinarof cream for the treatment of adolescents and adults with atopic dermatitis

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Progress in peptide and protein therapeutics: Challenges and strategies

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Epigallocatechin gallate/L-ascorbic acid–loaded poly-γ-glutamate microneedles with antioxidant, anti-inflammatory, and immunomodulatory effects for the treatment of atopic dermatitis

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Phase 2 clinical study of delgocitinib ointment in pediatric patients with atopic dermatitis

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Tight junctions in the development of asthma, chronic rhinosinusitis, atopic dermatitis, eosinophilic esophagitis, and inflammatory bowel diseases

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Staphylococcus aureus and the Cutaneous Microbiota Biofilms in the Pathogenesis of Atopic Dermatitis

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Asivatrep, a TRPV1 antagonist, for the topical treatment of atopic dermatitis: Phase 3, randomized, vehicle-controlled study (CAPTAIN-AD)

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Tight junctions and their regulation by non-coding RNAs

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Exploring the Pathogenesis and Mechanism-Targeted Treatments of Rosacea: Previous Understanding and Updates

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Rosacea Is Characterized by a Profoundly Diminished Skin Barrier

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Multipolarity of cytokine axes in the pathogenesis of atopic dermatitis in terms of age, race, species, disease stage and biomarkers

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Fermented Morinda citrifolia (Noni) Alleviates DNCB-Induced Atopic Dermatitis in NC/Nga Mice through Modulating Immune Balance and Skin Barrier Function

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Breaking the Barrier - Potent Anti-Inflammatory Activity following Efficient Topical Delivery of Etanercept using Thermoresponsive Nanogels

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Insights into atopic dermatitis gained from genetically defined mouse models

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Epidermal barrier function in dry, flaky and sensitive skin: A narrative review

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Atopic Dermatitis: Disease Background and Risk Factors

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Human β-defensin-3 attenuates atopic dermatitis–like inflammation through autophagy activation and the aryl hydrocarbon receptor signaling pathway

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Manipulating Microbiota to Treat Atopic Dermatitis: Functions and Therapies

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IL-17 Receptor A Maintains and Protects the Skin Barrier To Prevent Allergic Skin Inflammation

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Prostaglandin E2 stimulates adaptive IL-22 production and promotes allergic contact dermatitis

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