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Cited by 23melanin and skin pigmentationMelanoma and MAPK PathwaysEpigenetics and DNA Methylation

Epigenetic regulation during melanocyte development and homeostasis

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Dilshat, Ramile, Vu, Hong Nhung, Steingrímsson, Eiríkur·2021·Experimental Dermatology
DOI 10.1111/exd.14391
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Abstract

Melanocytes originate in the neural crest as precursor cells which then migrate and proliferate to reach their destination where they differentiate into pigment‐producing cells. Melanocytes not only determine the colour of hair, skin and eyes but also protect against the harmful effects of UV irradiation. The establishment of the melanocyte lineage is regulated by a defined set of transcription factors and signalling pathways that direct the specific gene expression programmes underpinning melanoblast specification, survival, migration, proliferation and differentiation. In addition, epigenetic modifiers and replacement histones play key roles in regulating gene expression and its timing during the different steps of this process. Here, we discuss the evidence for the role of epigenetic regulators in melanocyte development and function and how they interact with transcription factors and signalling pathways to establish and maintain this important cell lineage.

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  • The h3f3a gene family contracted at the ancestor node of Choprae clade, resulting in fewer paralogs.

    “We discovered that the h3f3a gene family contracted at the ancestor node of Choprae clade, resulting in fewer paralogs (Fig. 4A, Fig. S18, Table S7)44.”

    From Genomic and genetic insights into speciation and pigment pattern diversification in <i>Danio</i> fishes (2025) · cites this paper as [44]

    Section 2.3 (Histone variants) discusses h3f3a in zebrafish and the number of H3.3 histones in mice. It does not address the Choprae clade, an ancestral gene-family contraction, or fewer paralogs; searches for those terms found no supporting passage in our copy. (LLM, conf=0.75)

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Cited by

Sorted by citations

Authors
Dilshat, R., Vu, H. N., & Steingrímsson, E.
Affiliations
  • University of Iceland (IS)
  • Department of Biochemistry and Molecular Biology Faculty of Medicine BioMedical Center University of Iceland Reykjavik Iceland
ORCID
Venue
Experimental Dermatology
Publisher
Wiley
Published
2021-05-31
Volume
30
Issue
8
Pages
1033-1050
ISSN
  • 0906-6705 (ISSN-L)
  • 1600-0625
DOI
10.1111/exd.14391
OpenAlex
W3160631769
Cited by
23
References
6
Citations by year
2026: 5 · 2025: 5 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 1
FWCI
0.41
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Experimental Dermatology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords
melanocytes, epigenetic regulation, melanocyte development, melanocyte homeostasis, neural crest, melanocyte migration, melanocyte differentiation, transcription factors, signaling pathways, histone modifications, epigenetic regulators, UV protection, pigmentation
MeSH terms
Animals, Homeostasis, Humans, Melanocytes, Transcription Factors, Cell Lineage, Epigenesis, Genetic, Mice

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